PRKRIR: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
No edit summary
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''52 kDa repressor of the inhibitor of the protein kinase''' is an [[enzyme]] that in humans is encoded by the ''PRKRIR'' [[gene]].<ref name="pmid9447982">{{cite journal |author1=Gale M Jr |author2=Blakely CM |author3=Hopkins DA |author4=Melville MW |author5=Wambach M |author6=Romano PR |author7=Katze MG | title = Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK | journal = Mol Cell Biol | volume = 18 | issue = 2 | pages = 859–71 |date=Feb 1998 | pmid = 9447982 | pmc = 108797 | doi =  10.1128/mcb.18.2.859}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5612| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
| HGNCid = 9440
| Symbol = PRKRIR
| AltSymbols =; DAP4; MGC102750; P52rIPK
| OMIM = 607374
| ECnumber = 
| Homologene = 37952
| MGIid = 1920231
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5612
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_004696
    | Hs_RefseqmRNA = NM_004705
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr =
    | Hs_GenLoc_start =   
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 72981
    | Mm_Ensembl = ENSMUSG00000030753
    | Mm_RefseqmRNA = NM_028410
    | Mm_RefseqProtein = NP_082686
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 98578555
    | Mm_GenLoc_end = 98593254
    | Mm_Uniprot = Q8R201
  }}
}}
'''Protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)''', also known as '''PRKRIR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5612| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
Line 49: Line 6:
| summary_text =  
| summary_text =  
}}
}}
==Interactions==
PRKRIR has been shown to [[Protein-protein interaction|interact]] with [[STK4]]<ref name=pmid12384512>{{cite journal |last=Lin |first=Yenshou |authorlink= |author2=Khokhlatchev Andrei |author3=Figeys Daniel |author4=Avruch Joseph  |date=Dec 2002 |title=Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis |journal=J. Biol. Chem. |volume=277 |issue=50 |pages=47991–8001 |publisher= |location = United States| issn = 0021-9258| pmid = 12384512 |doi = 10.1074/jbc.M202630200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[DNAJC3]].<ref name=pmid9447982 />


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
Line 57: Line 16:
{{PBB_Further_reading
{{PBB_Further_reading
| citations =  
| citations =  
*{{cite journal  | author=Mellor H, Proud CG |title=A synthetic peptide substrate for initiation factor-2 kinases. |journal=Biochem. Biophys. Res. Commun. |volume=178 |issue= 2 |pages= 430-7 |year= 1991 |pmid= 1677563 |doi=  }}
*{{cite journal  |vauthors=Mellor H, Proud CG |title=A synthetic peptide substrate for initiation factor-2 kinases. |journal=Biochem. Biophys. Res. Commun. |volume=178 |issue= 2 |pages= 430–7 |year= 1991 |pmid= 1677563 |doi=10.1016/0006-291X(91)90125-Q }}
*{{cite journal | author=Polyak SJ, Tang N, Wambach M, ''et al.'' |title=The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity. |journal=J. Biol. Chem. |volume=271 |issue= 3 |pages= 1702-7 |year= 1996 |pmid= 8576172 |doi= }}
*{{cite journal   |vauthors=Polyak SJ, Tang N, Wambach M, etal |title=The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity. |journal=J. Biol. Chem. |volume=271 |issue= 3 |pages= 1702–7 |year= 1996 |pmid= 8576172 |doi=10.1074/jbc.271.3.1702 }}
*{{cite journal  | author=Gale M, Blakely CM, Hopkins DA, ''et al.'' |title=Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK. |journal=Mol. Cell. Biol. |volume=18 |issue= 2 |pages= 859-71 |year= 1998 |pmid= 9447982 |doi= }}
*{{cite journal   |vauthors=Shi Y, Vattem KM, Sood R, etal |title=Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. |journal=Mol. Cell. Biol. |volume=18 |issue= 12 |pages= 7499–509 |year= 1998 |pmid= 9819435 |doi= 10.1128/MCB.18.12.7499| pmc=109330 }}
*{{cite journal | author=Shi Y, Vattem KM, Sood R, ''et al.'' |title=Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. |journal=Mol. Cell. Biol. |volume=18 |issue= 12 |pages= 7499-509 |year= 1998 |pmid= 9819435 |doi=  }}
*{{cite journal   |vauthors=Lu J, O'Hara EB, Trieselmann BA, etal |title=The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha. |journal=J. Biol. Chem. |volume=274 |issue= 45 |pages= 32198–203 |year= 1999 |pmid= 10542257 |doi=10.1074/jbc.274.45.32198 }}
*{{cite journal | author=Lu J, O'Hara EB, Trieselmann BA, ''et al.'' |title=The interferon-induced double-stranded RNA-activated protein kinase PKR will phosphorylate serine, threonine, or tyrosine at residue 51 in eukaryotic initiation factor 2alpha. |journal=J. Biol. Chem. |volume=274 |issue= 45 |pages= 32198-203 |year= 1999 |pmid= 10542257 |doi=  }}
*{{cite journal  |vauthors=Saelens X, Kalai M, Vandenabeele P |title=Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 41620–8 |year= 2001 |pmid= 11555640 |doi= 10.1074/jbc.M103674200 }}
*{{cite journal  | author=Saelens X, Kalai M, Vandenabeele P |title=Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 41620-8 |year= 2001 |pmid= 11555640 |doi= 10.1074/jbc.M103674200 }}
*{{cite journal  |vauthors=Lin Y, Khokhlatchev A, Figeys D, Avruch J |title=Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 47991–8001 |year= 2003 |pmid= 12384512 |doi= 10.1074/jbc.M202630200 }}
*{{cite journal  | author=Lin Y, Khokhlatchev A, Figeys D, Avruch J |title=Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. |journal=J. Biol. Chem. |volume=277 |issue= 50 |pages= 47991-8001 |year= 2003 |pmid= 12384512 |doi= 10.1074/jbc.M202630200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Lee JH, Choi SR, Hwang TH, etal |title=A gene expression in study human gastric adenocarcinoma using a cDNA microarray. |journal=The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi |volume=42 |issue= 6 |pages= 484–95 |year= 2004 |pmid= 14695705 |doi=  }}
*{{cite journal | author=Lee JH, Choi SR, Hwang TH, ''et al.'' |title=A gene expression in study human gastric adenocarcinoma using a cDNA microarray. |journal=The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi |volume=42 |issue= 6 |pages= 484-95 |year= 2004 |pmid= 14695705 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Revision as of 23:58, 5 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

52 kDa repressor of the inhibitor of the protein kinase is an enzyme that in humans is encoded by the PRKRIR gene.[1][2]

Interactions

PRKRIR has been shown to interact with STK4[3] and DNAJC3.[1]

References

  1. ↑ 1.0 1.1 Gale M Jr; Blakely CM; Hopkins DA; Melville MW; Wambach M; Romano PR; Katze MG (Feb 1998). "Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK". Mol Cell Biol. 18 (2): 859–71. doi:10.1128/mcb.18.2.859. PMC 108797. PMID 9447982.
  2. ↑ "Entrez Gene: PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)".
  3. ↑ Lin, Yenshou; Khokhlatchev Andrei; Figeys Daniel; Avruch Joseph (Dec 2002). "Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis". J. Biol. Chem. United States. 277 (50): 47991–8001. doi:10.1074/jbc.M202630200. ISSN 0021-9258. PMID 12384512.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=PRKRIR&oldid=1414938"