ROBO2: Difference between revisions

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{{Underlinked|date=June 2016}}
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{{Infobox_gene}}
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'''Roundabout homolog 2''' is a [[protein]] that in humans is encoded by the ''ROBO2'' [[gene]].<ref name="pmid9458045">{{cite journal | vauthors = Kidd T, Brose K, Mitchell KJ, Fetter RD, Tessier-Lavigne M, Goodman CS, Tear G | title = Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors | journal = Cell | volume = 92 | issue = 2 | pages = 205–15 |date=Feb 1998 | pmid = 9458045 | pmc =  | doi =10.1016/S0092-8674(00)80915-0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6092| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_ROBO2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1uem.
| PDB = {{PDB2|1uem}}, {{PDB2|1ujt}}
| Name = Roundabout, axon guidance receptor, homolog 2 (Drosophila)
| HGNCid = 10250
| Symbol = ROBO2
| AltSymbols =; KIAA1568
| OMIM = 602431
| ECnumber =
| Homologene = 43188
| MGIid = 1890110
  | GeneAtlas_image1 = PBB_GE_ROBO2_gnf1h07141_at_tn.png
  | Function = {{GNF_GO|id=GO:0008046 |text = axon guidance receptor activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0030673 |text = axolemma}}
| Process = {{GNF_GO|id=GO:0001657 |text = ureteric bud development}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0050772 |text = positive regulation of axonogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6092
    | Hs_Ensembl = ENSG00000185008
    | Hs_RefseqProtein = NP_002933
    | Hs_RefseqmRNA = NM_002942
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 77172627
    | Hs_GenLoc_end = 77776744
    | Hs_Uniprot = Q9HCK4
    | Mm_EntrezGene = 268902
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_175549
    | Mm_RefseqProtein = NP_780758
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Roundabout, axon guidance receptor, homolog 2 (Drosophila)''', also known as '''ROBO2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6092| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Kidd T, Brose K, Mitchell KJ, ''et al.'' |title=Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. |journal=Cell |volume=92 |issue= 2 |pages= 205-15 |year= 1998 |pmid= 9458045 |doi=  }}
*{{cite journal   |vauthors=Brose K, Bland KS, Wang KH, etal |title=Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. |journal=Cell |volume=96 |issue= 6 |pages= 795–806 |year= 1999 |pmid= 10102268 |doi=10.1016/S0092-8674(00)80590-5 }}
*{{cite journal  | author=Brose K, Bland KS, Wang KH, ''et al.'' |title=Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. |journal=Cell |volume=96 |issue= 6 |pages= 795-806 |year= 1999 |pmid= 10102268 |doi=  }}
*{{cite journal   |vauthors=Nguyen Ba-Charvet KT, Brose K, Marillat V, etal |title=Slit2-Mediated chemorepulsion and collapse of developing forebrain axons. |journal=Neuron |volume=22 |issue= 3 |pages= 463–73 |year= 1999 |pmid= 10197527 |doi=10.1016/S0896-6273(00)80702-3 }}
*{{cite journal | author=Nguyen Ba-Charvet KT, Brose K, Marillat V, ''et al.'' |title=Slit2-Mediated chemorepulsion and collapse of developing forebrain axons. |journal=Neuron |volume=22 |issue= 3 |pages= 463-73 |year= 1999 |pmid= 10197527 |doi=  }}
*{{cite journal   |vauthors=Nagase T, Kikuno R, Nakayama M, etal |title=Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 4 |pages= 273–81 |year= 2001 |pmid= 10997877 |doi=  10.1093/dnares/7.4.271}}
*{{cite journal | author=Nagase T, Kikuno R, Nakayama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 4 |pages= 273-81 |year= 2001 |pmid= 10997877 |doi=  }}
*{{cite journal   |vauthors=Nguyen Ba-Charvet KT, Brose K, Ma L, etal |title=Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance. |journal=J. Neurosci. |volume=21 |issue= 12 |pages= 4281–9 |year= 2001 |pmid= 11404413 |doi=  }}
*{{cite journal | author=Nguyen Ba-Charvet KT, Brose K, Ma L, ''et al.'' |title=Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance. |journal=J. Neurosci. |volume=21 |issue= 12 |pages= 4281-9 |year= 2001 |pmid= 11404413 |doi=  }}
*{{cite journal   |vauthors=Marillat V, Cases O, Nguyen-Ba-Charvet KT, etal |title=Spatiotemporal expression patterns of slit and robo genes in the rat brain. |journal=J. Comp. Neurol. |volume=442 |issue= 2 |pages= 130–55 |year= 2002 |pmid= 11754167 |doi=10.1002/cne.10068 }}
*{{cite journal | author=Marillat V, Cases O, Nguyen-Ba-Charvet KT, ''et al.'' |title=Spatiotemporal expression patterns of slit and robo genes in the rat brain. |journal=J. Comp. Neurol. |volume=442 |issue= 2 |pages= 130-55 |year= 2002 |pmid= 11754167 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Hivert B, Liu Z, Chuang CY, etal |title=Robo1 and Robo2 are homophilic binding molecules that promote axonal growth. |journal=Mol. Cell. Neurosci. |volume=21 |issue= 4 |pages= 534–45 |year= 2003 |pmid= 12504588 |doi=10.1006/mcne.2002.1193 }}
*{{cite journal | author=Hivert B, Liu Z, Chuang CY, ''et al.'' |title=Robo1 and Robo2 are homophilic binding molecules that promote axonal growth. |journal=Mol. Cell. Neurosci. |volume=21 |issue= 4 |pages= 534-45 |year= 2003 |pmid= 12504588 |doi=  }}
*{{cite journal  | vauthors=Grieshammer U, Le M, Plump AS|title=SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. |journal=Dev. Cell |volume=6 |issue= 5 |pages= 709–17 |year= 2004 |pmid= 15130495 |doi=10.1016/S1534-5807(04)00108-X |display-authors=etal}}
*{{cite journal  | author=Grieshammer U, Le Ma , Plump AS, ''et al.'' |title=SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. |journal=Dev. Cell |volume=6 |issue= 5 |pages= 709-17 |year= 2004 |pmid= 15130495 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Yue Y, Grossmann B, Galetzka D, etal |title=Isolation and differential expression of two isoforms of the ROBO2/Robo2 axon guidance receptor gene in humans and mice. |journal=Genomics |volume=88 |issue= 6 |pages= 772–8 |year= 2007 |pmid= 16829019 |doi= 10.1016/j.ygeno.2006.05.011 }}
*{{cite journal | author=Yue Y, Grossmann B, Galetzka D, ''et al.'' |title=Isolation and differential expression of two isoforms of the ROBO2/Robo2 axon guidance receptor gene in humans and mice. |journal=Genomics |volume=88 |issue= 6 |pages= 772-8 |year= 2007 |pmid= 16829019 |doi= 10.1016/j.ygeno.2006.05.011 }}
*{{cite journal   |vauthors=Lu W, van Eerde AM, Fan X, etal |title=Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. |journal=Am. J. Hum. Genet. |volume=80 |issue= 4 |pages= 616–32 |year= 2007 |pmid= 17357069 |doi= 10.1086/512735 | pmc=1852714 }}
*{{cite journal | author=Lu W, van Eerde AM, Fan X, ''et al.'' |title=Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. |journal=Am. J. Hum. Genet. |volume=80 |issue= 4 |pages= 616-32 |year= 2007 |pmid= 17357069 |doi= 10.1086/512735 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=6092}}
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Revision as of 09:23, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Roundabout homolog 2 is a protein that in humans is encoded by the ROBO2 gene.[1][2]


References

  1. ↑ Kidd T, Brose K, Mitchell KJ, Fetter RD, Tessier-Lavigne M, Goodman CS, Tear G (Feb 1998). "Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors". Cell. 92 (2): 205–15. doi:10.1016/S0092-8674(00)80915-0. PMID 9458045.
  2. ↑ "Entrez Gene: ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)".

Further reading



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