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{{Infobox_gene}}
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'''SP110 nuclear body protein''' is a [[protein]] that in humans is encoded by the ''SP110'' [[gene]].<ref name="pmid7693701">{{cite journal | vauthors = Kadereit S, Gewert DR, Galabru J, Hovanessian AG, Meurs EF | title = Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins | journal = J Biol Chem | volume = 268 | issue = 32 | pages = 24432–41 |date=Dec 1993 | pmid = 7693701 | pmc = | doi = }}</ref><ref name="pmid10388521">{{cite journal | vauthors = Welsh GI, Kadereit S, Coccia EM, Hovanessian AG, Meurs EF | title = Colocalization within the nucleolus of two highly related IFN-induced human nuclear phosphoproteins with nucleolin | journal = Exp Cell Res | volume = 250 | issue = 1 | pages = 62–74 |date=Aug 1999 | pmid = 10388521 | pmc =  | doi = 10.1006/excr.1999.4505 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SP110 SP110 nuclear body protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3431| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = SP110 nuclear body protein
| HGNCid = 5401
| Symbol = SP110
| AltSymbols =; FLJ22835; IFI41; IFI75; VODI
| OMIM = 604457
| ECnumber = 
| Homologene = 82192
| MGIid = 1923364
| GeneAtlas_image1 = PBB_GE_SP110_209761_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SP110_208392_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_SP110_208012_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005062 |text = hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3431
    | Hs_Ensembl = ENSG00000135899
    | Hs_RefseqProtein = NP_004500
    | Hs_RefseqmRNA = NM_004509
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 230742084
    | Hs_GenLoc_end = 230789886
    | Hs_Uniprot = Q9HB58
    | Mm_EntrezGene = 109032
    | Mm_Ensembl =   
    | Mm_RefseqmRNA = XM_001004911
    | Mm_RefseqProtein = XP_001004911
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''SP110 nuclear body protein''', also known as '''SP110''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SP110 SP110 nuclear body protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3431| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =
| summary_text = The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: SP110 SP110 nuclear body protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3431| accessdate = }}</ref>
| summary_text = The nuclear body is a multiprotein complex that may have a role in the regulation of [[gene transcription]]. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a [[leukocyte]]-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in [[ribosome]] biogenesis and in the induction of [[myeloid]] cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct [[isoforms]], have been identified.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
*[https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=vodi  GeneReviews/NCBI/NIH/UW entry on Hepatic Veno-Occlusive Disease with Immunodeficiency]
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal | author=Kadereit S, Gewert DR, Galabru J, ''et al.'' |title=Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins. |journal=J. Biol. Chem. |volume=268 |issue= 32 |pages= 24432-41 |year= 1993 |pmid= 7693701 |doi=  }}
*{{cite journal   |vauthors=Bloch DB, Nakajima A, Gulick T, etal |title=Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator. |journal=Mol. Cell. Biol. |volume=20 |issue= 16 |pages= 6138–46 |year= 2000 |pmid= 10913195 |doi=10.1128/MCB.20.16.6138-6146.2000  | pmc=86089 }}
*{{cite journal  | author=Welsh GI, Kadereit S, Coccia EM, ''et al.'' |title=Colocalization within the nucleolus of two highly related IFN-induced human nuclear phosphoproteins with nucleolin. |journal=Exp. Cell Res. |volume=250 |issue= 1 |pages= 62-74 |year= 1999 |pmid= 10388521 |doi= 10.1006/excr.1999.4505 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Bloch DB, Nakajima A, Gulick T, ''et al.'' |title=Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator. |journal=Mol. Cell. Biol. |volume=20 |issue= 16 |pages= 6138-46 |year= 2000 |pmid= 10913195 |doi=  }}
*{{cite journal   |vauthors=Izmailova E, Bertley FM, Huang Q, etal |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Watashi K, Hijikata M, Tagawa A, etal |title=Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7498–509 |year= 2003 |pmid= 14559998 |doi=10.1128/MCB.23.21.7498-7509.2003  | pmc=207568 }}
*{{cite journal | author=Izmailova E, Bertley FM, Huang Q, ''et al.'' |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191-7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822 }}
*{{cite journal  | vauthors=Nicewonger J, Suck G, Bloch D, Swaminathan S |title=Epstein-Barr virus (EBV) SM protein induces and recruits cellular Sp110b to stabilize mRNAs and enhance EBV lytic gene expression. |journal=J. Virol. |volume=78 |issue= 17 |pages= 9412–22 |year= 2004 |pmid= 15308735 |doi= 10.1128/JVI.78.17.9412-9422.2004 | pmc=506926 }}
*{{cite journal | author=Watashi K, Hijikata M, Tagawa A, ''et al.'' |title=Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7498-509 |year= 2003 |pmid= 14559998 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Nicewonger J, Suck G, Bloch D, Swaminathan S |title=Epstein-Barr virus (EBV) SM protein induces and recruits cellular Sp110b to stabilize mRNAs and enhance EBV lytic gene expression. |journal=J. Virol. |volume=78 |issue= 17 |pages= 9412-22 |year= 2004 |pmid= 15308735 |doi= 10.1128/JVI.78.17.9412-9422.2004 }}
*{{cite journal   |vauthors=Roscioli T, Cliffe ST, Bloch DB, etal |title=Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease. |journal=Nat. Genet. |volume=38 |issue= 6 |pages= 620–2 |year= 2006 |pmid= 16648851 |doi= 10.1038/ng1780 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Tosh K, Campbell SJ, Fielding K, etal |title=Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 27 |pages= 10364–8 |year= 2006 |pmid= 16803959 |doi= 10.1073/pnas.0603340103 | pmc=1502463 }}
*{{cite journal | author=Roscioli T, Cliffe ST, Bloch DB, ''et al.'' |title=Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease. |journal=Nat. Genet. |volume=38 |issue= 6 |pages= 620-2 |year= 2006 |pmid= 16648851 |doi= 10.1038/ng1780 }}
*{{cite journal   |vauthors=Thye T, Browne EN, Chinbuah MA, etal |title=No associations of human pulmonary tuberculosis with Sp110 variants. |journal=J. Med. Genet. |volume=43 |issue= 7 |pages= e32 |year= 2006 |pmid= 16816019 |doi= 10.1136/jmg.2005.037960 | pmc=2564561 }}
*{{cite journal | author=Tosh K, Campbell SJ, Fielding K, ''et al.'' |title=Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 27 |pages= 10364-8 |year= 2006 |pmid= 16803959 |doi= 10.1073/pnas.0603340103 }}
*{{cite journal   |vauthors=Warren EH, Vigneron NJ, Gavin MA, etal |title=An antigen produced by splicing of noncontiguous peptides in the reverse order. |journal=Science |volume=313 |issue= 5792 |pages= 1444–7 |year= 2006 |pmid= 16960008 |doi= 10.1126/science.1130660 }}
*{{cite journal | author=Thye T, Browne EN, Chinbuah MA, ''et al.'' |title=No associations of human pulmonary tuberculosis with Sp110 variants. |journal=J. Med. Genet. |volume=43 |issue= 7 |pages= e32 |year= 2006 |pmid= 16816019 |doi= 10.1136/jmg.2005.037960 }}
*{{cite journal   |vauthors=Szeszko JS, Healy B, Stevens H, etal |title=Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis. |journal=Hum. Genet. |volume=121 |issue= 2 |pages= 155–60 |year= 2007 |pmid= 17149599 |doi= 10.1007/s00439-006-0293-z }}
*{{cite journal | author=Warren EH, Vigneron NJ, Gavin MA, ''et al.'' |title=An antigen produced by splicing of noncontiguous peptides in the reverse order. |journal=Science |volume=313 |issue= 5792 |pages= 1444-7 |year= 2006 |pmid= 16960008 |doi= 10.1126/science.1130660 }}
*{{cite journal  | vauthors=Babb C, Keet EH, van Helden PD, Hoal EG |title=SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population. |journal=Hum. Genet. |volume=121 |issue= 3-4 |pages= 521–2 |year= 2007 |pmid= 17287948 |doi= 10.1007/s00439-007-0335-1 }}
*{{cite journal | author=Szeszko JS, Healy B, Stevens H, ''et al.'' |title=Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis. |journal=Hum. Genet. |volume=121 |issue= 2 |pages= 155-60 |year= 2007 |pmid= 17149599 |doi= 10.1007/s00439-006-0293-z }}
*{{cite journal   |vauthors=Cliffe ST, Wong M, Taylor PJ, etal |title=The first prenatal diagnosis for veno-occlusive disease and immunodeficiency syndrome, an autosomal recessive condition associated with mutations in SP110. |journal=Prenat. Diagn. |volume=27 |issue= 7 |pages= 674–6 |year= 2007 |pmid= 17510920 |doi= 10.1002/pd.1759 }}
*{{cite journal  | author=Babb C, Keet EH, van Helden PD, Hoal EG |title=SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population. |journal=Hum. Genet. |volume=121 |issue= 3-4 |pages= 521-2 |year= 2007 |pmid= 17287948 |doi= 10.1007/s00439-007-0335-1 }}
*{{cite journal   |vauthors=de la Fuente J, Manzano-Roman R, Blouin EF, etal |title=Sp110 transcription is induced and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. |journal=BMC Infect. Dis. |volume=7|pages= 110 |year= 2007 |pmid= 17883869 |doi= 10.1186/1471-2334-7-110 | pmc=2039740 }}
*{{cite journal | author=Cliffe ST, Wong M, Taylor PJ, ''et al.'' |title=The first prenatal diagnosis for veno-occlusive disease and immunodeficiency syndrome, an autosomal recessive condition associated with mutations in SP110. |journal=Prenat. Diagn. |volume=27 |issue= 7 |pages= 674-6 |year= 2007 |pmid= 17510920 |doi= 10.1002/pd.1759 }}
*{{cite journal | author=de la Fuente J, Manzano-Roman R, Blouin EF, ''et al.'' |title=Sp110 transcription is induced and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. |journal=BMC Infect. Dis. |volume=7 |issue=  |pages= 110 |year= 2007 |pmid= 17883869 |doi= 10.1186/1471-2334-7-110 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:51, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SP110 nuclear body protein is a protein that in humans is encoded by the SP110 gene.[1][2][3]

The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified.[3]

References

  1. ↑ Kadereit S, Gewert DR, Galabru J, Hovanessian AG, Meurs EF (Dec 1993). "Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins". J Biol Chem. 268 (32): 24432–41. PMID 7693701.
  2. ↑ Welsh GI, Kadereit S, Coccia EM, Hovanessian AG, Meurs EF (Aug 1999). "Colocalization within the nucleolus of two highly related IFN-induced human nuclear phosphoproteins with nucleolin". Exp Cell Res. 250 (1): 62–74. doi:10.1006/excr.1999.4505. PMID 10388521.
  3. ↑ 3.0 3.1 "Entrez Gene: SP110 SP110 nuclear body protein".

External links

Further reading



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