PUM1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Pumilio homolog 1''' is a [[protein]] that in humans is encoded by the ''PUM1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PUM1 pumilio homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9698| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_PUM1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ib2.
| PDB = {{PDB2|1ib2}}, {{PDB2|1m8w}}, {{PDB2|1m8x}}, {{PDB2|1m8y}}, {{PDB2|1m8z}}
| Name = Pumilio homolog 1 (Drosophila)
| HGNCid = 14957
| Symbol = PUM1
| AltSymbols =; HSPUM; KIAA0099; PUMH; PUMH1; PUML1
| OMIM = 607204
| ECnumber = 
| Homologene = 22830
| MGIid = 1931749
| GeneAtlas_image1 = PBB_GE_PUM1_201166_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PUM1_201164_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PUM1_201165_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005488 |text = binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006417 |text = regulation of translation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9698
    | Hs_Ensembl = ENSG00000134644
    | Hs_RefseqProtein = NP_001018494
    | Hs_RefseqmRNA = NM_001020658
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 31176940
    | Hs_GenLoc_end = 31311350
    | Hs_Uniprot = Q14671
    | Mm_EntrezGene = 80912
    | Mm_Ensembl = ENSMUSG00000028580
    | Mm_RefseqmRNA = NM_030722
    | Mm_RefseqProtein = NP_109647
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 129935455
    | Mm_GenLoc_end = 130053638
    | Mm_Uniprot = Q3TQ21
  }}
}}
'''Pumilio homolog 1 (Drosophila)''', also known as '''PUM1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PUM1 pumilio homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9698| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the PUF family, [[evolutionarily conserved]] RNA-binding proteins related to the Pumilio proteins of ''[[Drosophila]]'' and the fem-3 mRNA binding factor proteins of ''[[Caenorhabditis elegans|C. elegans]]''. The encoded protein contains a sequence-specific RNA binding domain composed of eight repeats and N- and C-terminal flanking regions, and serves as a [[Translational regulation|translational regulator]] of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of [[embryogenesis]], and cell development and differentiation. [[Splice variant|Alternatively spliced]] transcript variants encoding different isoforms have been described.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: PUM1 pumilio homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9698| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Spassov DS, Jurecic R |title=The PUF family of RNA-binding proteins: does evolutionarily conserved structure equal conserved function? |journal=IUBMB Life |volume=55 |issue= 7 |pages= 359–66 |year= 2004 |pmid= 14584586 |doi=10.1080/15216540310001603093 }}
| citations =
*{{cite journal  | author=Nagase T |title=Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1 |journal=DNA Res. |volume=2 |issue= 1 |pages= 37–43 |year= 1995 |pmid= 7788527 |doi=10.1093/dnares/2.1.37 |name-list-format=vanc| author2=Miyajima N  | author3=Tanaka A  | display-authors=3  | last4=Sazuka  | first4=T  | last5=Seki  | first5=N  | last6=Sato | first6=S  | last7=Tabata  | first7=S  | last8=Ishikawa  | first8=K  | last9=Kawarabayasi  | first9=Y }}
*{{cite journal  | author=Spassov DS, Jurecic R |title=The PUF family of RNA-binding proteins: does evolutionarily conserved structure equal conserved function? |journal=IUBMB Life |volume=55 |issue= 7 |pages= 359-66 |year= 2004 |pmid= 14584586 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Nagase T, Miyajima N, Tanaka A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 1 |pages= 37-43 |year= 1995 |pmid= 7788527 |doi= }}
*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-format=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3  | last4=Suyama  | first4=A  | last5=Sugano  | first5=S }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  |vauthors=Wang X, Zamore PD, Hall TM |title=Crystal structure of a Pumilio homology domain |journal=Mol. Cell |volume=7 |issue= 4 |pages= 855–65 |year= 2001 |pmid= 11336708 |doi=10.1016/S1097-2765(01)00229-5  }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Wang X, McLachlan J, Zamore PD, Hall TM |title=Modular recognition of RNA by a human pumilio-homology domain |journal=Cell |volume=110 |issue= 4 |pages= 501–12 |year= 2002 |pmid= 12202039 |doi=10.1016/S0092-8674(02)00873-5  }}
*{{cite journal  | author=Wang X, Zamore PD, Hall TM |title=Crystal structure of a Pumilio homology domain. |journal=Mol. Cell |volume=7 |issue= 4 |pages= 855-65 |year= 2001 |pmid= 11336708 |doi=  }}
*{{cite journal  |vauthors=Spassov DS, Jurecic R |title=Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins |journal=Gene |volume=299 |issue= 1–2 |pages= 195–204 |year= 2003 |pmid= 12459267 |doi=10.1016/S0378-1119(02)01060-0  }}
*{{cite journal  | author=Wang X, McLachlan J, Zamore PD, Hall TM |title=Modular recognition of RNA by a human pumilio-homology domain. |journal=Cell |volume=110 |issue= 4 |pages= 501-12 |year= 2002 |pmid= 12202039 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS | last7=Wagner | first7=L | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Spassov DS, Jurecic R |title=Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins. |journal=Gene |volume=299 |issue= 1-2 |pages= 195-204 |year= 2003 |pmid= 12459267 |doi=  }}
*{{cite journal  | author=Dazard JE |title=Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer |journal=Oncogene |volume=22 |issue= 19 |pages= 2993–3006 |year= 2003 |pmid= 12771951 |doi= 10.1038/sj.onc.1206537  |name-list-format=vanc| author2=Gal H  | author3=Amariglio N  | display-authors=3  | last4=Rechavi  | first4=Gideon  | last5=Domany  | first5=Eytan  | last6=Givol  | first6=David }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Dazard JE, Gal H, Amariglio N, ''et al.'' |title=Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer. |journal=Oncogene |volume=22 |issue= 19 |pages= 2993-3006 |year= 2003 |pmid= 12771951 |doi= 10.1038/sj.onc.1206537 }}
*{{cite journal  | author=Brandenberger R |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |name-list-format=vanc| author2=Wei H  | author3=Zhang S  | display-authors=3  | last4=Lei  | first4=Shirley  | last5=Murage  | first5=Jaji  | last6=Fisk  | first6=Gregory J  | last7=Li  | first7=Yan  | last8=Xu  | first8=Chunhui  | last9=Fang  | first9=Rixun }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Colland F |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104  | pmc=442148  |name-list-format=vanc| author2=Jacq X  | author3=Trouplin V  | display-authors=3  | last4=Mougin  | first4=C  | last5=Groizeleau  | first5=C  | last6=Hamburger  | first6=A  | last7=Meil  | first7=A  | last8=Wojcik  | first8=J  | last9=Legrain  | first9=P }}
*{{cite journal  | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Jordanova A |title=Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy |journal=Nat. Genet. |volume=38 |issue= 2 |pages= 197–202 |year= 2006 |pmid= 16429158 |doi= 10.1038/ng1727  |name-list-format=vanc| author2=Irobi J  | author3=Thomas FP  | display-authors=3  | last4=Van Dijck  | first4=Patrick  | last5=Meerschaert  | first5=Kris  | last6=Dewil  | first6=Maarten  | last7=Dierick  | first7=Ines  | last8=Jacobs  | first8=An  | last9=De Vriendt  | first9=Els }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Gregory SG |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727  |name-list-format=vanc| author2=Barlow KF  | author3=McLay KE  | display-authors=3  | last4=Kaul  | first4=R.  | last5=Swarbreck  | first5=D.  | last6=Dunham  | first6=A.  | last7=Scott  | first7=C. E.  | last8=Howe  | first8=K. L.  | last9=Woodfine  | first9=K. }}
*{{cite journal  | author=Jordanova A, Irobi J, Thomas FP, ''et al.'' |title=Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. |journal=Nat. Genet. |volume=38 |issue= 2 |pages= 197-202 |year= 2006 |pmid= 16429158 |doi= 10.1038/ng1727 }}
*{{cite journal  | author=Lim J |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032  |name-list-format=vanc| author2=Hao T  | author3=Shaw C  | display-authors=3  | last4=Patel  | first4=Akash J.  | last5=Szabó  | first5=Gábor  | last6=Rual  | first6=Jean-François  | last7=Fisk  | first7=C. Joseph  | last8=Li  | first8=Ning  | last9=Smolyar  | first9=Alex }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026  |name-list-format=vanc| author2=Blagoev B  | author3=Gnad F  | display-authors=3  | last4=Macek  | first4=Boris  | last5=Kumar  | first5=Chanchal  | last6=Mortensen  | first6=Peter  | last7=Mann  | first7=Matthias }}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 19:00, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Pumilio homolog 1 is a protein that in humans is encoded by the PUM1 gene.[1]

Function

This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain composed of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: PUM1 pumilio homolog 1 (Drosophila)".

Further reading


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