PIK3C2B: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide''' is an [[enzyme]] that in humans is encoded by the ''PIK3C2B'' [[gene]].<ref name="pmid9144573">{{cite journal | vauthors = Brown RA, Ho LK, Weber-Hall SJ, Shipley JM, Fry MJ | title = Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K | journal = Biochemical and Biophysical Research Communications | volume = 233 | issue = 2 | pages = 537–44 | date = Apr 1997 | pmid = 9144573 | pmc =  | doi = 10.1006/bbrc.1997.6495 }}</ref><ref name="pmid9830063">{{cite journal | vauthors = Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, Layton MJ, Gout I, Ahmadi K, Downward J, Waterfield MD | title = Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity | journal = The Journal of Biological Chemistry | volume = 273 | issue = 49 | pages = 33082–90 | date = Dec 1998 | pmid = 9830063 | pmc = | doi = 10.1074/jbc.273.49.33082 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5287| accessdate = }}</ref>
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Phosphoinositide-3-kinase, class 2, beta polypeptide
| HGNCid = 8972
| Symbol = PIK3C2B
| AltSymbols =; C2-PI3K; DKFZp686G16234
| OMIM = 602838
| ECnumber = 
| Homologene = 20582
| MGIid = 2685045
| GeneAtlas_image1 = PBB_GE_PIK3C2B_204484_at_tn.png
| Function = {{GNF_GO|id=GO:0004428 |text = inositol or phosphatidylinositol kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016303 |text = 1-phosphatidylinositol-3-kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0035005 |text = phosphatidylinositol-4-phosphate 3-kinase activity}} {{GNF_GO|id=GO:0035091 |text = phosphoinositide binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005942 |text = phosphoinositide 3-kinase complex}}
| Process = {{GNF_GO|id=GO:0007154 |text = cell communication}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5287
    | Hs_Ensembl = ENSG00000133056
    | Hs_RefseqProtein = NP_002637
    | Hs_RefseqmRNA = NM_002646
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 202658379
    | Hs_GenLoc_end = 202726175
    | Hs_Uniprot = O00750
    | Mm_EntrezGene = 240752
    | Mm_Ensembl = ENSMUSG00000026447
    | Mm_RefseqmRNA = XM_001001586
    | Mm_RefseqProtein = XP_001001586
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 134873586
    | Mm_GenLoc_end = 134933698
    | Mm_Uniprot = 
  }}
}}
'''Phosphoinositide-3-kinase, class 2, beta polypeptide''', also known as '''PIK3C2B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5287| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene belongs to the [[phosphoinositide 3-kinase]] (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, [[cell migration]], and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a [[C-terminal]] C2 domain, a characteristic of class II PI3-kinases. C2 domains act as [[calcium in biology|calcium]]-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor [[wortmannin]]. The C2 domain of this protein was shown to bind phospholipids but not [[calcium in biology|Ca<sup>2+</sup>]], which suggests that this enzyme may function in a calcium-independent manner.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.<ref name="entrez">{{cite web | title = Entrez Gene: PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5287| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG | title = Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways | journal = Journal of Leukocyte Biology | volume = 74 | issue = 5 | pages = 676–82 | date = Nov 2003 | pmid = 12960231 | doi = 10.1189/jlb.0503206 }}
| citations =
* {{cite journal | vauthors = Kozutsumi H, Toyoshima H, Hagiwara K, Yazaki Y, Hirai H | title = Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo | journal = Oncogene | volume = 9 | issue = 10 | pages = 2991–8 | date = Oct 1994 | pmid = 8084603 | doi =  }}
*{{cite journal | author=Lee C, Liu QH, Tomkowicz B, ''et al.'' |title=Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 676-82 |year= 2004 |pmid= 12960231 |doi= 10.1189/jlb.0503206 }}
* {{cite journal | vauthors = Milani D, Mazzoni M, Borgatti P, Zauli G, Cantley L, Capitani S | title = Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells | journal = The Journal of Biological Chemistry | volume = 271 | issue = 38 | pages = 22961–4 | date = Sep 1996 | pmid = 8798481 | doi = 10.1074/jbc.271.38.22961 }}
*{{cite journal | author=Kozutsumi H, Toyoshima H, Hagiwara K, ''et al.'' |title=Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo. |journal=Oncogene |volume=9 |issue= 10 |pages= 2991-8 |year= 1994 |pmid= 8084603 |doi=  }}
* {{cite journal | vauthors = Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H | title = The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase | journal = Oncogene | volume = 14 | issue = 25 | pages = 3067–72 | date = Jun 1997 | pmid = 9223670 | doi = 10.1038/sj.onc.1201153 }}
*{{cite journal | author=Milani D, Mazzoni M, Borgatti P, ''et al.'' |title=Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 22961-4 |year= 1996 |pmid= 8798481 |doi= }}
* {{cite journal | vauthors = Mazerolles F, Barbat C, Fischer A | title = Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity | journal = European Journal of Immunology | volume = 27 | issue = 9 | pages = 2457–65 | date = Sep 1997 | pmid = 9341793 | doi = 10.1002/eji.1830270946 }}
*{{cite journal | author=Brown RA, Ho LK, Weber-Hall SJ, ''et al.'' |title=Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K. |journal=Biochem. Biophys. Res. Commun. |volume=233 |issue= 2 |pages= 537-44 |year= 1997 |pmid= 9144573 |doi= 10.1006/bbrc.1997.6495 }}
* {{cite journal | vauthors = Borgatti P, Zauli G, Colamussi ML, Gibellini D, Previati M, Cantley LL, Capitani S | title = Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells | journal = European Journal of Immunology | volume = 27 | issue = 11 | pages = 2805–11 | date = Nov 1997 | pmid = 9394803 | doi = 10.1002/eji.1830271110 }}
*{{cite journal | author=Ueno H, Honda H, Nakamoto T, ''et al.'' |title=The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase. |journal=Oncogene |volume=14 |issue= 25 |pages= 3067-72 |year= 1997 |pmid= 9223670 |doi= 10.1038/sj.onc.1201153 }}
* {{cite journal | vauthors = Borgatti P, Zauli G, Cantley LC, Capitani S | title = Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells | journal = Biochemical and Biophysical Research Communications | volume = 242 | issue = 2 | pages = 332–7 | date = Jan 1998 | pmid = 9446795 | doi = 10.1006/bbrc.1997.7877 }}
*{{cite journal | author=Mazerolles F, Barbat C, Fischer A |title=Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity. |journal=Eur. J. Immunol. |volume=27 |issue= 9 |pages= 2457-65 |year= 1997 |pmid= 9341793 |doi= }}
* {{cite journal | vauthors = Milani D, Mazzoni M, Zauli G, Mischiati C, Gibellini D, Giacca M, Capitani S | title = HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells | journal = Aids | volume = 12 | issue = 11 | pages = 1275–84 | date = Jul 1998 | pmid = 9708406 | doi = 10.1097/00002030-199811000-00008 }}
*{{cite journal | author=Borgatti P, Zauli G, Colamussi ML, ''et al.'' |title=Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. |journal=Eur. J. Immunol. |volume=27 |issue= 11 |pages= 2805-11 |year= 1998 |pmid= 9394803 |doi= }}
* {{cite journal | vauthors = Jauliac S, Mazerolles F, Jabado N, Pallier A, Bernard F, Peake J, Fischer A, Hivroz C | title = Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity | journal = European Journal of Immunology | volume = 28 | issue = 10 | pages = 3183–91 | date = Oct 1998 | pmid = 9808187 | doi = 10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A }}
*{{cite journal | author=Borgatti P, Zauli G, Cantley LC, Capitani S |title=Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 2 |pages= 332-7 |year= 1998 |pmid= 9446795 |doi= }}
* {{cite journal | vauthors = Arcaro A, Zvelebil MJ, Wallasch C, Ullrich A, Waterfield MD, Domin J | title = Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors | journal = Molecular and Cellular Biology | volume = 20 | issue = 11 | pages = 3817–30 | date = Jun 2000 | pmid = 10805725 | pmc = 85707 | doi = 10.1128/MCB.20.11.3817-3830.2000 }}
*{{cite journal | author=Milani D, Mazzoni M, Zauli G, ''et al.'' |title=HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells. |journal=AIDS |volume=12 |issue= 11 |pages= 1275-84 |year= 1998 |pmid= 9708406 |doi= }}
* {{cite journal | vauthors = Park IW, Wang JF, Groopman JE | title = HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes | journal = Blood | volume = 97 | issue = 2 | pages = 352–8 | date = Jan 2001 | pmid = 11154208 | doi = 10.1182/blood.V97.2.352 }}
*{{cite journal | author=Jauliac S, Mazerolles F, Jabado N, ''et al.'' |title=Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity. |journal=Eur. J. Immunol. |volume=28 |issue= 10 |pages= 3183-91 |year= 1998 |pmid= 9808187 |doi= }}
* {{cite journal | vauthors = Zauli G, Milani D, Mirandola P, Mazzoni M, Secchiero P, Miscia S, Capitani S | title = HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway | journal = FASEB Journal | volume = 15 | issue = 2 | pages = 483–91 | date = Feb 2001 | pmid = 11156964 | doi = 10.1096/fj.00-0354com }}
*{{cite journal | author=Arcaro A, Volinia S, Zvelebil MJ, ''et al.'' |title=Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 33082-90 |year= 1999 |pmid= 9830063 |doi= }}
* {{cite journal | vauthors = Wheeler M, Domin J | title = Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2 | journal = Molecular and Cellular Biology | volume = 21 | issue = 19 | pages = 6660–7 | date = Oct 2001 | pmid = 11533253 | pmc = 99811 | doi = 10.1128/MCB.21.19.6660-6667.2001 }}
*{{cite journal | author=Arcaro A, Zvelebil MJ, Wallasch C, ''et al.'' |title=Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. |journal=Mol. Cell. Biol. |volume=20 |issue= 11 |pages= 3817-30 |year= 2000 |pmid= 10805725 |doi= }}
* {{cite journal | vauthors = Deregibus MC, Cantaluppi V, Doublier S, Brizzi MF, Deambrosis I, Albini A, Camussi G | title = HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 28 | pages = 25195–202 | date = Jul 2002 | pmid = 11994280 | doi = 10.1074/jbc.M200921200 }}
*{{cite journal | author=Park IW, Wang JF, Groopman JE |title=HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes. |journal=Blood |volume=97 |issue= 2 |pages= 352-8 |year= 2001 |pmid= 11154208 |doi= }}
* {{cite journal | vauthors = Cook JA, August A, Henderson AJ | title = Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism | journal = Journal of Immunology | volume = 169 | issue = 1 | pages = 254–60 | date = Jul 2002 | pmid = 12077252 | doi = 10.4049/jimmunol.169.1.254 }}
*{{cite journal | author=Zauli G, Milani D, Mirandola P, ''et al.'' |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. |journal=FASEB J. |volume=15 |issue= 2 |pages= 483-91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com }}
* {{cite journal | vauthors = Arcaro A, Khanzada UK, Vanhaesebroeck B, Tetley TD, Waterfield MD, Seckl MJ | title = Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation | journal = The EMBO Journal | volume = 21 | issue = 19 | pages = 5097–108 | date = Oct 2002 | pmid = 12356726 | pmc = 129034 | doi = 10.1093/emboj/cdf512 }}
*{{cite journal | author=Wheeler M, Domin J |title=Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2. |journal=Mol. Cell. Biol. |volume=21 |issue= 19 |pages= 6660-7 |year= 2001 |pmid= 11533253 |doi= }}
* {{cite journal | vauthors = Visnjić D, Crljen V, Curić J, Batinić D, Volinia S, Banfić H | title = The activation of nuclear phosphoinositide 3-kinase C2beta in all-trans-retinoic acid-differentiated HL-60 cells | journal = FEBS Letters | volume = 529 | issue = 2-3 | pages = 268–74 | date = Oct 2002 | pmid = 12372612 | doi = 10.1016/S0014-5793(02)03357-4 }}
*{{cite journal | author=Deregibus MC, Cantaluppi V, Doublier S, ''et al.'' |title=HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25195-202 |year= 2002 |pmid= 11994280 |doi= 10.1074/jbc.M200921200 }}
*{{cite journal | author=Cook JA, August A, Henderson AJ |title=Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism. |journal=J. Immunol. |volume=169 |issue= 1 |pages= 254-60 |year= 2002 |pmid= 12077252 |doi= }}
*{{cite journal  | author=Arcaro A, Khanzada UK, Vanhaesebroeck B, ''et al.'' |title=Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation. |journal=EMBO J. |volume=21 |issue= 19 |pages= 5097-108 |year= 2002 |pmid= 12356726 |doi=  }}
*{{cite journal  | author=Visnjić D, Crljen V, Curić J, ''et al.'' |title=The activation of nuclear phosphoinositide 3-kinase C2beta in all-trans-retinoic acid-differentiated HL-60 cells. |journal=FEBS Lett. |volume=529 |issue= 2-3 |pages= 268-74 |year= 2002 |pmid= 12372612 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{refend}}


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Revision as of 18:08, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide is an enzyme that in humans is encoded by the PIK3C2B gene.[1][2][3]

Function

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmannin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.[3]

References

  1. ↑ Brown RA, Ho LK, Weber-Hall SJ, Shipley JM, Fry MJ (Apr 1997). "Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K". Biochemical and Biophysical Research Communications. 233 (2): 537–44. doi:10.1006/bbrc.1997.6495. PMID 9144573.
  2. ↑ Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, Layton MJ, Gout I, Ahmadi K, Downward J, Waterfield MD (Dec 1998). "Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity". The Journal of Biological Chemistry. 273 (49): 33082–90. doi:10.1074/jbc.273.49.33082. PMID 9830063.
  3. ↑ 3.0 3.1 "Entrez Gene: PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide".

Further reading


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