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{{Infobox_gene}}
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'''Tumor-associated calcium signal transducer 2''', also known as '''Trop-2''' and as '''epithelial glycoprotein-1''' antigen (EGP-1),<ref>Immunomedics Awarded Fast Track Designation by FDA for Sacituzumab Govitecan (IMMU-132) for Triple-Negative Breast Cancer Therapy [http://globenewswire.com/news-release/2015/01/05/694944/10113907/en/Immunomedics-Awarded-Fast-Track-Designation-by-FDA-for-Sacituzumab-Govitecan-IMMU-132-for-Triple-Negative-Breast-Cancer-Therapy.html]</ref> is a [[protein]] that in humans is encoded by the ''TACSTD2'' [[gene]].<ref name="pmid8382772">{{cite journal | vauthors = Linnenbach AJ, Seng BA, Wu S, Robbins S, Scollon M, Pyrc JJ, Druck T, Huebner K | title = Retroposition in a family of carcinoma-associated antigen genes | journal = Mol Cell Biol | volume = 13 | issue = 3 | pages = 1507–15 |date=Apr 1993 | pmid = 8382772 | pmc = 359462 | doi =  }}</ref><ref name="pmid11306819">{{cite journal | vauthors = Calabrese G, Crescenzi C, Morizio E, Palka G, Guerra E, Alberti S | title = Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization | journal = Cytogenet Cell Genet | volume = 92 | issue = 1-2 | pages = 164–5 |date=Apr 2001 | pmid = 11306819 | pmc = | doi =10.1159/000056891  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TACSTD2 tumor-associated calcium signal transducer 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4070| accessdate = }}</ref>
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This [[intron]]less gene encodes a carcinoma-associated [[antigen]] defined by the monoclonal antibody [[GA733]]. This antigen is a member of a family including at least two type I [[membrane protein]]s. It transduces an intracellular [[calcium]] signal and acts as a [[cell surface receptor]].
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Mutations of this gene result in [[gelatinous drop-like corneal dystrophy]], an [[autosomal recessive]] disorder characterized by severe corneal [[amyloidosis]] leading to [[blindness]].<ref name="entrez"/>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Tumor-associated calcium signal transducer 2
| HGNCid = 11530
| Symbol = TACSTD2
| AltSymbols =; EGP-1; GA733; GA733-1; M1S1; TROP2
| OMIM = 137290
| ECnumber = 
| Homologene = 1763
| MGIid = 1861606
| GeneAtlas_image1 = PBB_GE_TACSTD2_202286_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TACSTD2_202287_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4070
    | Hs_Ensembl = ENSG00000184292
    | Hs_RefseqProtein = NP_002344
    | Hs_RefseqmRNA = NM_002353
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 58813683
    | Hs_GenLoc_end = 58816033
    | Hs_Uniprot = P09758
    | Mm_EntrezGene = 56753
    | Mm_Ensembl = ENSMUSG00000051397
    | Mm_RefseqmRNA = NM_020047
    | Mm_RefseqProtein = NP_064431
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 67464331
    | Mm_GenLoc_end = 67465284
    | Mm_Uniprot = 
  }}
}}
'''Tumor-associated calcium signal transducer 2''', also known as '''TACSTD2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TACSTD2 tumor-associated calcium signal transducer 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4070| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This antigen is the target of [[sacituzumab govitecan]], an [[antibody-drug conjugate]].
{{PBB_Summary
| section_title =
| summary_text = This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.<ref name="entrez">{{cite web | title = Entrez Gene: TACSTD2 tumor-associated calcium signal transducer 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4070| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Linnenbach AJ, Wojcierowski J, Wu SA, ''et al.'' |title=Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 1 |pages= 27-31 |year= 1989 |pmid= 2911574 |doi=  }}
*{{cite journal   |vauthors=Linnenbach AJ, Wojcierowski J, Wu SA, etal |title=Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 1 |pages= 27–31 |year= 1989 |pmid= 2911574 |doi=10.1073/pnas.86.1.27  | pmc=286396 }}
*{{cite journal | author=Fornaro M, Dell'Arciprete R, Stella M, ''et al.'' |title=Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. |journal=Int. J. Cancer |volume=62 |issue= 5 |pages= 610-8 |year= 1995 |pmid= 7665234 |doi=  }}
*{{cite journal   |vauthors=Fornaro M, Dell'Arciprete R, Stella M, etal |title=Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. |journal=Int. J. Cancer |volume=62 |issue= 5 |pages= 610–8 |year= 1995 |pmid= 7665234 |doi=10.1002/ijc.2910620520 }}
*{{cite journal  | author=Linnenbach AJ, Seng BA, Wu S, ''et al.'' |title=Retroposition in a family of carcinoma-associated antigen genes. |journal=Mol. Cell. Biol. |volume=13 |issue= 3 |pages= 1507-15 |year= 1993 |pmid= 8382772 |doi=  }}
*{{cite journal  | vauthors=El Sewedy T, Fornaro M, Alberti S |title=Cloning of the murine TROP2 gene: conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2. |journal=Int. J. Cancer |volume=75 |issue= 2 |pages= 324–30 |year= 1998 |pmid= 9462726 |doi=10.1002/(SICI)1097-0215(19980119)75:2<324::AID-IJC24>3.0.CO;2-B }}
*{{cite journal  | author=El Sewedy T, Fornaro M, Alberti S |title=Cloning of the murine TROP2 gene: conservation of a PIP2-binding sequence in the cytoplasmic domain of TROP-2. |journal=Int. J. Cancer |volume=75 |issue= 2 |pages= 324-30 |year= 1998 |pmid= 9462726 |doi= }}
*{{cite journal  | vauthors=Ripani E, Sacchetti A, Corda D, Alberti S |title=Human Trop-2 is a tumor-associated calcium signal transducer. |journal=Int. J. Cancer |volume=76 |issue= 5 |pages= 671–6 |year= 1998 |pmid= 9610724 |doi=10.1002/(SICI)1097-0215(19980529)76:5<671::AID-IJC10>3.0.CO;2-7  }}
*{{cite journal | author=Ripani E, Sacchetti A, Corda D, Alberti S |title=Human Trop-2 is a tumor-associated calcium signal transducer. |journal=Int. J. Cancer |volume=76 |issue= 5 |pages= 671-6 |year= 1998 |pmid= 9610724 |doi= }}
*{{cite journal   |vauthors=Tsujikawa M, Kurahashi H, Tanaka T, etal |title=Identification of the gene responsible for gelatinous drop-like corneal dystrophy. |journal=Nat. Genet. |volume=21 |issue= 4 |pages= 420–3 |year= 1999 |pmid= 10192395 |doi= 10.1038/7759 }}
*{{cite journal | author=Tsujikawa M, Kurahashi H, Tanaka T, ''et al.'' |title=Identification of the gene responsible for gelatinous drop-like corneal dystrophy. |journal=Nat. Genet. |volume=21 |issue= 4 |pages= 420-3 |year= 1999 |pmid= 10192395 |doi= 10.1038/7759 }}
*{{cite journal   |vauthors=Nakamura T, Nishida K, Dota A, etal |title=Gelatino-lattice corneal dystrophy: clinical features and mutational analysis. |journal=Am. J. Ophthalmol. |volume=129 |issue= 5 |pages= 665–6 |year= 2000 |pmid= 10844062 |doi=10.1016/S0002-9394(00)00369-X  }}
*{{cite journal | author=Nakamura T, Nishida K, Dota A, ''et al.'' |title=Gelatino-lattice corneal dystrophy: clinical features and mutational analysis. |journal=Am. J. Ophthalmol. |volume=129 |issue= 5 |pages= 665-6 |year= 2000 |pmid= 10844062 |doi=  }}
*{{cite journal   |vauthors=Kinoshita S, Nishida K, Dota A, Abbie F, etal |title=Epithelial barrier function and ultrastructure of gelatinous drop-like corneal dystrophy. |journal=Cornea |volume=19 |issue= 4 |pages= 551–5 |year= 2000 |pmid= 10928776 |doi=10.1097/00003226-200007000-00029 }}
*{{cite journal | author=Kinoshita S, Nishida K, Dota A, ''et al.'' |title=Epithelial barrier function and ultrastructure of gelatinous drop-like corneal dystrophy. |journal=Cornea |volume=19 |issue= 4 |pages= 551-5 |year= 2000 |pmid= 10928776 |doi=  }}
*{{cite journal   |vauthors=Tsujikawa M, Tsujikawa K, Maeda N, etal |title=Rapid detection of M1S1 mutations by the protein truncation test. |journal=Invest. Ophthalmol. Vis. Sci. |volume=41 |issue= 9 |pages= 2466–8 |year= 2000 |pmid= 10937555 |doi=  }}
*{{cite journal | author=Tsujikawa M, Tsujikawa K, Maeda N, ''et al.'' |title=Rapid detection of M1S1 mutations by the protein truncation test. |journal=Invest. Ophthalmol. Vis. Sci. |volume=41 |issue= 9 |pages= 2466-8 |year= 2000 |pmid= 10937555 |doi=  }}
*{{cite journal   |vauthors=Ha NT, Fujiki K, Hotta Y, etal |title=Q118X mutation of M1S1 gene caused gelatinous drop-like corneal dystrophy: the P501T of BIGH3 gene found in a family with gelatinous drop-like corneal dystrophy. |journal=Am. J. Ophthalmol. |volume=130 |issue= 1 |pages= 119–20 |year= 2000 |pmid= 11004271 |doi=10.1016/S0002-9394(00)00596-1 }}
*{{cite journal | author=Ha NT, Fujiki K, Hotta Y, ''et al.'' |title=Q118X mutation of M1S1 gene caused gelatinous drop-like corneal dystrophy: the P501T of BIGH3 gene found in a family with gelatinous drop-like corneal dystrophy. |journal=Am. J. Ophthalmol. |volume=130 |issue= 1 |pages= 119-20 |year= 2000 |pmid= 11004271 |doi=  }}
*{{cite journal   |vauthors=Tasa G, Kals J, Muru K, etal |title=A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy. |journal=Invest. Ophthalmol. Vis. Sci. |volume=42 |issue= 12 |pages= 2762–4 |year= 2001 |pmid= 11687514 |doi=  }}
*{{cite journal | author=Calabrese G, Crescenzi C, Morizio E, ''et al.'' |title=Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=92 |issue= 1-2 |pages= 164-5 |year= 2001 |pmid= 11306819 |doi=  }}
*{{cite journal   |vauthors=Yoshida S, Kumano Y, Yoshida A, etal |title=Two brothers with gelatinous drop-like dystrophy at different stages of the disease: role of mutational analysis. |journal=Am. J. Ophthalmol. |volume=133 |issue= 6 |pages= 830–2 |year= 2002 |pmid= 12036680 |doi=10.1016/S0002-9394(02)01407-1 }}
*{{cite journal | author=Tasa G, Kals J, Muru K, ''et al.'' |title=A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy. |journal=Invest. Ophthalmol. Vis. Sci. |volume=42 |issue= 12 |pages= 2762-4 |year= 2001 |pmid= 11687514 |doi= }}
*{{cite journal   |vauthors=Ren Z, Lin PY, Klintworth GK, etal |title=Allelic and locus heterogeneity in autosomal recessive gelatinous drop-like corneal dystrophy. |journal=Hum. Genet. |volume=110 |issue= 6 |pages= 568–77 |year= 2002 |pmid= 12107443 |doi= 10.1007/s00439-002-0729-z }}
*{{cite journal | author=Yoshida S, Kumano Y, Yoshida A, ''et al.'' |title=Two brothers with gelatinous drop-like dystrophy at different stages of the disease: role of mutational analysis. |journal=Am. J. Ophthalmol. |volume=133 |issue= 6 |pages= 830-2 |year= 2002 |pmid= 12036680 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Ren Z, Lin PY, Klintworth GK, ''et al.'' |title=Allelic and locus heterogeneity in autosomal recessive gelatinous drop-like corneal dystrophy. |journal=Hum. Genet. |volume=110 |issue= 6 |pages= 568-77 |year= 2002 |pmid= 12107443 |doi= 10.1007/s00439-002-0729-z }}
*{{cite journal   |vauthors=Ha NT, Chau HM, Cung le X, etal |title=A novel mutation of M1S1 gene found in a Vietnamese patient with gelatinous droplike corneal dystrophy. |journal=Am. J. Ophthalmol. |volume=135 |issue= 3 |pages= 390–3 |year= 2003 |pmid= 12614764 |doi=10.1016/S0002-9394(02)01952-9  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gires O, Eskofier S, Lang S, etal |title=Cloning and characterisation of a 1.1 kb fragment of the carcinoma-associated epithelial cell adhesion molecule promoter. |journal=Anticancer Res. |volume=23 |issue= 4 |pages= 3255–61 |year= 2003 |pmid= 12926061 |doi= }}
*{{cite journal | author=Ha NT, Chau HM, Cung le X, ''et al.'' |title=A novel mutation of M1S1 gene found in a Vietnamese patient with gelatinous droplike corneal dystrophy. |journal=Am. J. Ophthalmol. |volume=135 |issue= 3 |pages= 390-3 |year= 2003 |pmid= 12614764 |doi= }}
*{{cite journal   |vauthors=Tian X, Fujiki K, Li Q, etal |title=Compound heterozygous mutations of M1S1 gene in gelatinous droplike corneal dystrophy. |journal=Am. J. Ophthalmol. |volume=137 |issue= 3 |pages= 567–9 |year= 2004 |pmid= 15013888 |doi= 10.1016/j.ajo.2003.08.008 }}
*{{cite journal | author=Gires O, Eskofier S, Lang S, ''et al.'' |title=Cloning and characterisation of a 1.1 kb fragment of the carcinoma-associated epithelial cell adhesion molecule promoter. |journal=Anticancer Res. |volume=23 |issue= 4 |pages= 3255-61 |year= 2003 |pmid= 12926061 |doi= }}
*{{cite journal   |vauthors=Murakami A, Kimura S, Fujiki K, etal |title=Mutations in the membrane component, chromosome 1, surface marker 1 (M1S1) gene in gelatinous drop-like corneal dystrophy. |journal=Jpn. J. Ophthalmol. |volume=48 |issue= 4 |pages= 317–20 |year= 2004 |pmid= 15295654 |doi= 10.1007/s10384-003-0064-5 }}
*{{cite journal | author=Tian X, Fujiki K, Li Q, ''et al.'' |title=Compound heterozygous mutations of M1S1 gene in gelatinous droplike corneal dystrophy. |journal=Am. J. Ophthalmol. |volume=137 |issue= 3 |pages= 567-9 |year= 2004 |pmid= 15013888 |doi= 10.1016/j.ajo.2003.08.008 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Murakami A, Kimura S, Fujiki K, ''et al.'' |title=Mutations in the membrane component, chromosome 1, surface marker 1 (M1S1) gene in gelatinous drop-like corneal dystrophy. |journal=Jpn. J. Ophthalmol. |volume=48 |issue= 4 |pages= 317-20 |year= 2004 |pmid= 15295654 |doi= 10.1007/s10384-003-0064-5 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
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Revision as of 11:30, 15 September 2017

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External IDsGeneCards: [2]
Orthologs
SpeciesHumanMouse
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Wikidata
View/Edit Human

Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1),[1] is a protein that in humans is encoded by the TACSTD2 gene.[2][3][4]

This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor.

Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.[4]

This antigen is the target of sacituzumab govitecan, an antibody-drug conjugate.

References

  1. ↑ Immunomedics Awarded Fast Track Designation by FDA for Sacituzumab Govitecan (IMMU-132) for Triple-Negative Breast Cancer Therapy [1]
  2. ↑ Linnenbach AJ, Seng BA, Wu S, Robbins S, Scollon M, Pyrc JJ, Druck T, Huebner K (Apr 1993). "Retroposition in a family of carcinoma-associated antigen genes". Mol Cell Biol. 13 (3): 1507–15. PMC 359462. PMID 8382772.
  3. ↑ Calabrese G, Crescenzi C, Morizio E, Palka G, Guerra E, Alberti S (Apr 2001). "Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization". Cytogenet Cell Genet. 92 (1–2): 164–5. doi:10.1159/000056891. PMID 11306819.
  4. ↑ 4.0 4.1 "Entrez Gene: TACSTD2 tumor-associated calcium signal transducer 2".

Further reading



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