Secondary peritonitis pathophysiology: Difference between revisions
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* The initial inoculum of bacteria is determined by the normal flora in the involved portion of the GI tract. | * The initial inoculum of bacteria is determined by the normal flora in the involved portion of the GI tract. | ||
===Flora=== | ===Flora=== | ||
Microbial | Microbial organisms causing secondary peritonitis depends on the site of the gut perforation.<ref name="pmid15846719">{{cite journal| author=Wong PF, Gilliam AD, Kumar S, Shenfine J, O'Dair GN, Leaper DJ| title=Antibiotic regimens for secondary peritonitis of gastrointestinal origin in adults. | journal=Cochrane Database Syst Rev | year= 2005 | volume= | issue= 2 | pages= CD004539 | pmid=15846719 | doi=10.1002/14651858.CD004539.pub2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15846719 }} </ref> | ||
* Small bowel perforation: Consist mainly of enterococci and Escherichia coli | * Small bowel perforation: Consist mainly of enterococci and Escherichia coli | ||
* Distal small bowel lumen perforation: Mostly Enterobacteriaceae and anaerobic organisms, including the Bacteroides sps. | * Distal small bowel lumen perforation: Mostly Enterobacteriaceae and anaerobic organisms, including the Bacteroides sps. |
Revision as of 22:36, 4 February 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shivani Chaparala M.B.B.S [2]
Overview
Pathophysiology
- Bacteria can reach the peritoneal cavity by a variety of pathologic processes:
- Transmural inflammation with luminal obstruction,
- Perforation of the GI tract, and
- Intestinal ischemia.
- The initial inoculum of bacteria is determined by the normal flora in the involved portion of the GI tract.
Flora
Microbial organisms causing secondary peritonitis depends on the site of the gut perforation.[1]
- Small bowel perforation: Consist mainly of enterococci and Escherichia coli
- Distal small bowel lumen perforation: Mostly Enterobacteriaceae and anaerobic organisms, including the Bacteroides sps.
- Colon: Mostly anaerobes (e.g. Peptostreptococcus, Clostridium, and most commonly Bacteroides sps)
References
- ↑ Wong PF, Gilliam AD, Kumar S, Shenfine J, O'Dair GN, Leaper DJ (2005). "Antibiotic regimens for secondary peritonitis of gastrointestinal origin in adults". Cochrane Database Syst Rev (2): CD004539. doi:10.1002/14651858.CD004539.pub2. PMID 15846719.