Creutzfeldt-Jakob disease physical examination: Difference between revisions

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Revision as of 20:06, 22 March 2016

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Physical examination is required for the diagnosis of ‪Creutzfeldt-Jakob disease‬. Physical examination findings of ‪Creutzfeldt-Jakob disease‬findings include myoclonus, extrapyramidal signs, akinetic mutism, and visual or cerebellar signs^[1]

Physical Examination

General Appearance

Patients with Creutzfeldt-Jakob disease‬ often appear confused.

Neurologic Examination

Speech impairment
Jerky movements (myoclonus)
Balance and coordination dysfunction (ataxia)
Gait disturbances
Rigid posture
Seizures

↑ Rabinovici, GD.; Wang, PN.; Levin, J.; Cook, L.; Pravdin, M.; Davis, J.; DeArmond, SJ.; Barbaro, NM.; Martindale, J. (2006). "First symptom in sporadic Creutzfeldt-Jakob disease". Neurology. 66 (2): 286–7. doi:10.1212/01.wnl.0000196440.00297.67. PMID 16434680. Unknown parameter |month= ignored (help)

[Rabinovici-2006-1] Rabinovici, GD.; Wang, PN.; Levin, J.; Cook, L.; Pravdin, M.; Davis, J.; DeArmond, SJ.; Barbaro, NM.; Martindale, J. (2006). "First symptom in sporadic Creutzfeldt-Jakob disease". Neurology. 66 (2): 286–7. doi:10.1212/01.wnl.0000196440.00297.67. PMID 16434680. Unknown parameter |month= ignored (help)

[1]

@@ Line 6: / Line 6: @@
 ==Physical Examination==
-===Neurologic===
+===General Appearance===
+*Patients with Creutzfeldt-Jakob disease‬ often appear confused.
+===Neurologic Examination===
 * [[Speech communication|Speech]] impairment
 * Jerky movements ([[myoclonus]])
@@ Line 13: / Line 16: @@
 * [[posture|Rigid posture]]
 * [[Seizures]]
-===Diagnostic Criteria===
-====Criteria for a Probable Diagnosis====
-Diagnosis of Creutzfeldt Jakob disease is '''probable''' if following criteria are fulfilled:
-* Rapidly progressive dementia plus at least any 2 of the following features
-:* Myoclonus
-:* Visual or cerebellar signs
-:* Pyramidal and/or extrapyramidal signs
-:* [[Akinetic mutism]]
-PLUS<br>
-* Positive result on one of the following laboratory tests:
-:* Typical [[EEG]] (periodic sharp wave complexes) during an illness of any duration and/or
-:* A positive 14-3-3 [[cerebrospinal fluid]] (CSF) assay in patients with a disease duration of less than 2 years and/or
-:* Magnetic resonance imaging (MRI): high signal abnormalities in [[caudate nucleus]] and/or [[putamen]] on diffusion-weighted imaging (DWI) or fluid attenuated inversion recovery (FLAIR).
-PLUS<br>
-* No alternative diagnosis is suspected on routine investigation.<ref name="www.cdc.gov">{{Cite web  | last =  | first =  | title = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | url = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | publisher =  | date =  | accessdate = 17 February 2014 }}</ref>
-====Criteria for a Possible Diagnosis====
-Diagnosis of Creutzfeldt Jakob disease is '''possible''' if following criteria are fulfilled:
-* Rapidly progressive dementia plus at least any 2 of the following features
-:* [[Myoclonus]]
-:* Visual or cerebellar signs
-:* Pyramidal and/or extrapyramidal signs
-:* [[Akinetic mutism]]
-PLUS<br>
-* Absence of a positive result for any of the three laboratory tests that would classify a case as probable (see above).<br>
-PLUS<br>
-* Duration of illness is less than two years.<br>
-PLUS<br>
-* No alternative diagnosis is suspected on routine investigation.<ref name="www.cdc.gov">{{Cite web  | last =  | first =  | title = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | url = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | publisher =  | date =  | accessdate = 17 February 2014 }}</ref>
-==References==
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