Croup pathophysiology: Difference between revisions

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***Positive-[[sense]] RNA strand
***Positive-[[sense]] RNA strand
***Negative-[[sense]] RNA strand
***Negative-[[sense]] RNA strand
 
**The negative-sense RNA strand is encapsidated by [[nucleoprotein]] and is then used for further transcription and replication
*HPIV is transmitted by contact with infected secretions through respiratory droplets or contaminated surfaces or objects.  
*HPIV is transmitted by contact with infected secretions through respiratory droplets or contaminated surfaces or objects.  
*HPIV infection usually begins at the [[epithelium]] in the [[Upper Respiratory Tract|upper respiratory tract]], spreading to the paranasal sinuses, larynx and bronchi.<ref name="SchomackerSchaap-Nutt2012">{{cite journal|last1=Schomacker|first1=Henrick|last2=Schaap-Nutt|first2=Anne|last3=Collins|first3=Peter L|last4=Schmidt|first4=Alexander C|title=Pathogenesis of acute respiratory illness caused by human parainfluenza viruses|journal=Current Opinion in Virology|volume=2|issue=3|year=2012|pages=294–299|issn=18796257|doi=10.1016/j.coviro.2012.02.001}}</ref>
*HPIV infection usually begins at the [[epithelium]] in the [[Upper Respiratory Tract|upper respiratory tract]], spreading to the paranasal sinuses, larynx and bronchi.<ref name="SchomackerSchaap-Nutt2012">{{cite journal|last1=Schomacker|first1=Henrick|last2=Schaap-Nutt|first2=Anne|last3=Collins|first3=Peter L|last4=Schmidt|first4=Alexander C|title=Pathogenesis of acute respiratory illness caused by human parainfluenza viruses|journal=Current Opinion in Virology|volume=2|issue=3|year=2012|pages=294–299|issn=18796257|doi=10.1016/j.coviro.2012.02.001}}</ref>

Revision as of 16:56, 26 January 2016

Croup Microchapters

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Overview

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor-In-Chief: Ujjwal Rastogi, MBBS [2]

Overview

The viral infection that causes croup leads to swelling of the larynx, trachea, and large bronchi due to infiltration of white blood cells (especially histiocytes, lymphocytes, plasma cells, and neutrophils). Swelling produces airway obstruction which, when significant, leads to dramatically increased work of breathing and the characteristic turbulent, noisy airflow known as stridor.

Pathogenesis

Viral Croup

References

  1. Cherry, James D. (2008). "Croup". New England Journal of Medicine. 358 (4): 384–391. doi:10.1056/NEJMcp072022. ISSN 0028-4793.
  2. 2.0 2.1 2.2 Henrickson, K. J. (2003). "Parainfluenza Viruses". Clinical Microbiology Reviews. 16 (2): 242–264. doi:10.1128/CMR.16.2.242-264.2003. ISSN 0893-8512.
  3. Schomacker, Henrick; Schaap-Nutt, Anne; Collins, Peter L; Schmidt, Alexander C (2012). "Pathogenesis of acute respiratory illness caused by human parainfluenza viruses". Current Opinion in Virology. 2 (3): 294–299. doi:10.1016/j.coviro.2012.02.001. ISSN 1879-6257.


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