Waldenström's macroglobulinemia laboratory findings: Difference between revisions

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*Elevated [[creatinine]]
*Elevated [[creatinine]]
*Electrolyte abnormalities:
*Electrolyte abnormalities:
:*Hypercalcemia(4%)
:*[[Hypercalcemia]](4%)
*Elevated [[erythrocyte sedimentation rate]] and [[uric acid]]
*Elevated [[erythrocyte sedimentation rate]] and [[uric acid]]
*Total protein levels
*Total protein levels

Revision as of 01:06, 11 January 2016

Waldenström's macroglobulinemia Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]

Overview

M spike of IgM type of immunoglobulin is diagnostic of waldenström's macroglobulinemia. [1][2]

Laboratory Findings

Complete blood count

Peripheral smear

  • Plasmacytoid lymphocytes
  • Normocytic normochromic red blood cells
  • Rouleaux formation

Serum and urine protein electrophoresis

  • Screening test for waldenström's macroglobulinemia [2]
  • Detection of M spike

Serum and urine immunofixation

  • Confirmatory test for waldenström's macroglobulinemia[2]
  • Determines the IgM type of immunoglobulin

Chemistry lab tests

Plasma viscosity

  • Plasma viscosity should be measured in patients presenting with hyperviscosity syndrome whenever the monoclonal IgM protein spike is >4 g/dL.
  • The normal plasma viscosity is 1.8 centipoise.
  • Patients start presenting with hyperviscosity symptoms when viscosity >4 centipoise.

References

  1. 1.0 1.1 García-Sanz R, Montoto S, Torrequebrada A, de Coca AG, Petit J, Sureda A, Rodríguez-García JA, Massó P, Pérez-Aliaga A, Monteagudo MD, Navarro I, Moreno G, Toledo C, Alonso A, Besses C, Besalduch J, Jarque I, Salama P, Rivas JA, Navarro B, Bladé J, Miguel JF (2001). "Waldenström macroglobulinaemia: presenting features and outcome in a series with 217 cases". Br. J. Haematol. 115 (3): 575–82. PMID 11736938.
  2. 2.0 2.1 2.2 Waldenström macroglobulinaemia. American Cancer Society (2015) http://www.cancer.org/cancer/waldenstrommacroglobulinemia/detailedguide/waldenstrom-macroglobulinemia-diagnosis Accessed on November 15th, 2015

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