Insulinoma pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
==Genetics== | ==Genetics== | ||
*Insulinoma can occur in association with inherited syndrome, such as [[multiple endocrine neoplasia type 1]] [[von Hippel- | *Insulinoma can occur in association with inherited syndrome, such as [[multiple endocrine neoplasia type 1]], [[von Hippel-Lindau syndrome]] or sporadic.<ref name="pmid3498768">{{cite journal| author=Murray PD, McKenzie DT, Swain SL, Kagnoff MF| title=Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression. | journal=J Immunol | year= 1987 | volume= 139 | issue= 8 | pages= 2669-74 | pmid=3498768 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3498768 }} </ref> | ||
*Multiple endocrine neoplasia type 1 is an autosomal dominant disorder caused by alterations of the ''MEN1'' gene located at chromosomal region 11q13. | *Multiple endocrine neoplasia type 1 is an autosomal dominant disorder caused by alterations of the ''MEN1'' gene located at chromosomal region 11q13. | ||
*Approximately 10% of insulinomas are multiple and 10% malignant.<ref> Insulinoma. Dr Yuranga Weerakkody and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/insulinoma</ref> | *Approximately 10% of insulinomas are multiple and 10% malignant.<ref> Insulinoma. Dr Yuranga Weerakkody and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/insulinoma</ref> | ||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
Revision as of 20:36, 1 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Pathophysiology
Genetics
- Insulinoma can occur in association with inherited syndrome, such as multiple endocrine neoplasia type 1, von Hippel-Lindau syndrome or sporadic.[1]
- Multiple endocrine neoplasia type 1 is an autosomal dominant disorder caused by alterations of the MEN1 gene located at chromosomal region 11q13.
- Approximately 10% of insulinomas are multiple and 10% malignant.[2]
Microscopic Pathology
On microscopic histopathological analysis characteristic findings of insulinoma are:
- Solid or gyriform patterns, usually without glands
-
![Histopathology of pancreatic endocrine tumor (insulinoma). H&E stain[3]](/images/2/2d/Pancreatic_insulinoma_Histology_1.JPG)
Histopathology of pancreatic endocrine tumor (insulinoma). H&E stain[3]
-
![Histopathology of pancreatic endocrine tumor (insulinoma)[3]](/images/2/2f/Pancreatic_insulinoma_histology_2.JPG)
Histopathology of pancreatic endocrine tumor (insulinoma)[3]
-
![Histopathology of pancreatic endocrine tumor (insulinoma). Chromogranin A immunostain[3]](/images/a/a3/Pancreatic_insulinoma_histopathology_3.JPG)
Histopathology of pancreatic endocrine tumor (insulinoma). Chromogranin A immunostain[3]
-
![Histopathology of pancreatic endocrine tumor (insulinoma). Insulin immunostain[3]](/images/d/d5/Pancreatic_insulinoma_histology_4.JPG)
Histopathology of pancreatic endocrine tumor (insulinoma). Insulin immunostain[3]
![Histopathology of pancreatic endocrine tumor (insulinoma). H&E stain[3]](/index.php/File:Pancreatic_insulinoma_Histology_1.JPG)
![Histopathology of pancreatic endocrine tumor (insulinoma)[3]](/index.php/File:Pancreatic_insulinoma_histology_2.JPG)
![Histopathology of pancreatic endocrine tumor (insulinoma). Chromogranin A immunostain[3]](/index.php/File:Pancreatic_insulinoma_histopathology_3.JPG)
![Histopathology of pancreatic endocrine tumor (insulinoma). Insulin immunostain[3]](/index.php/File:Pancreatic_insulinoma_histology_4.JPG)
References
- ↑ Murray PD, McKenzie DT, Swain SL, Kagnoff MF (1987). "Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression". J Immunol. 139 (8): 2669–74. PMID 3498768.
- ↑ Insulinoma. Dr Yuranga Weerakkody and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/insulinoma
- ↑ 3.0 3.1 3.2 3.3 Neuroendocrine tumour of the pancreas. Libre Pathology. http://librepathology.org/wiki/index.php/Neuroendocrine_tumour_of_the_pancreas