Multiple endocrine neoplasia type 1 medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
Pharmacologic medical therapies for multiple endocrine neoplasia type 1 include cabergoline, somatostatin analogues, and H2- receptor blockers. | |||
==Management== | ==Management== | ||
* Because the type of pancreatic endocrine cancer associated with MEN1 can be difficult to recognize, difficult to treat, and slow to progress, there are different views about the value of surgery in managing these tumors. | * Because the type of pancreatic endocrine cancer associated with MEN1 can be difficult to recognize, difficult to treat, and slow to progress, there are different views about the value of surgery in managing these tumors. |
Revision as of 15:06, 10 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [3]
Overview
Pharmacologic medical therapies for multiple endocrine neoplasia type 1 include cabergoline, somatostatin analogues, and H2- receptor blockers.
Management
- Because the type of pancreatic endocrine cancer associated with MEN1 can be difficult to recognize, difficult to treat, and slow to progress, there are different views about the value of surgery in managing these tumors.
- One approach is to "watch and wait," using medical, or nonsurgical, treatments. According to this school of thought, pancreatic surgery has serious complications, so it should not be attempted unless it will cure a tumor or cure a hormone excess state.
- Excessive release of certain hormones-mainly gastrin-from pancreatic endocrine cancer in MEN1 needs to be treated, and medications are often effective in blocking the effects of these hormones.[1]
- Cabergoline is the treatment of choice for prolactinomas.
- Somatostatin analogues such as octreotide, lanreotide are used for the treatment of growth hormone secreting tumors.
- H2- receptor blockade and proton pump inhibitors are used to reduce the gastric output in gastrinomas.