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==Overview==
==Overview==
Endometrial cancer may be classified according to histology into 7 subtypes: Endometrioid, Uterine papillary serous, MucinousClear cell, Squamous cell and Mixed.
Endometrial cancer may be classified according to histology into 7 subtypes: endometrioid, uterine papillary serous, mucinousclear cell, squamous cell, mixed and undifferentiated.


==Classification==
==Classification==
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'''Cellular Classification of Endometrial Cancer'''
'''Cellular Classification of Endometrial Cancer'''
: 1. Endometrioid (75%–80%).[The most common endometrial cancer cell type is endometrioid adenocarcinoma, which is composed of malignant glandular epithelial elements]
: 1. Endometrioid (75%–80%).[The most common endometrial cancer cell type is endometrioid adenocarcinoma, which is composed of malignant glandular epithelial elements]
::* Ciliated adenocarcinoma.
::* Ciliated adenocarcinoma
::* Secretory adenocarcinoma.
::* Secretory adenocarcinoma
::* Papillary or villoglandular.
::* Papillary or villoglandular
::* Adenocarcinoma with squamous differentiation.
::* Adenocarcinoma with squamous differentiation
:::* Adenoacanthoma.
:::* Adenoacanthoma
:::* Adenosquamous.[Adenosquamous tumors contain malignant elements of both glandular and squamous epithelium]
:::* Adenosquamous.[Adenosquamous tumors contain malignant elements of both glandular and squamous epithelium]
: 2. Uterine papillary serous (<10%).
: 2. Uterine papillary serous (<10%)
: 3. Mucinous (1%).
: 3. Mucinous (1%)
: 4. Clear cell (4%).
: 4. Clear cell (4%)
: 5. Squamous cell (<1%).
: 5. Squamous cell (<1%)
: 6. Mixed (10%).
: 6. Mixed (10%)
: 7. Undifferentiated
: 7. Undifferentiated



Revision as of 14:11, 2 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Endometrial cancer may be classified according to histology into 7 subtypes: endometrioid, uterine papillary serous, mucinous, clear cell, squamous cell, mixed and undifferentiated.

Classification

  • Endometrial cancers are classified in one of the following two categories:
  • Type 1 may arise from complex atypical hyperplasia and is pathogenetically linked to unopposed estrogenic stimulation.
  • Type 2 develops from atrophic endometrium and is not linked to hormonally driven pathogenesis.

Cellular Classification of Endometrial Cancer

1. Endometrioid (75%–80%).[The most common endometrial cancer cell type is endometrioid adenocarcinoma, which is composed of malignant glandular epithelial elements]
  • Ciliated adenocarcinoma
  • Secretory adenocarcinoma
  • Papillary or villoglandular
  • Adenocarcinoma with squamous differentiation
  • Adenoacanthoma
  • Adenosquamous.[Adenosquamous tumors contain malignant elements of both glandular and squamous epithelium]
2. Uterine papillary serous (<10%)
3. Mucinous (1%)
4. Clear cell (4%)
5. Squamous cell (<1%)
6. Mixed (10%)
7. Undifferentiated

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