Rhabdomyosarcoma pathophysiology: Difference between revisions
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====Embryonal Rhabdomyosarcoma==== | ====Embryonal Rhabdomyosarcoma==== | ||
*Randomly arranged small cells | *Randomly arranged small cells. | ||
*Myxoid matrix | *Myxoid matrix. | ||
*Strap cells: Tadpole like morphology | *Strap cells: Tadpole like morphology. | ||
*Rhabdomyoblasts: Essentially diagnostic cells with [[Nucleus|eccentric nucleus]] and Moderate amount of intensely eosinophilic cytoplasm | *Rhabdomyoblasts: Essentially diagnostic cells with [[Nucleus|eccentric nucleus]] and Moderate amount of intensely eosinophilic cytoplasm. | ||
====Botryoid Rhabdomyosarcoma==== | |||
*Non-proliferating layer deep to the surface called "Cambium layer". | |||
*Cambium layer is defined as cellular region deep to epithelial component. | |||
Revision as of 15:45, 1 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Microscopic Pathology
Characteristic features on microscopic analysis are variable depending on the chondrosarcoma subtype:
Alveolar Rhabdomyosarcoma
- Characterized by Alveolus-like pattern
- Fibrous septae lined by tumor cells
- Cells may "fall-off" the septa, i.e. be detached/scattered in the alveolus-like space
- Space between fibrous septae may be filled with tumor, called solid variant of alveolar rhabdomyosarcoma
- Rhabdomyoblasts: Essentially diagnostic cells with eccentric nucleus and Moderate amount of intensely eosinophilic cytoplasm
- Nuclear pleomorphism
- Mitoses
Embryonal Rhabdomyosarcoma
- Randomly arranged small cells.
- Myxoid matrix.
- Strap cells: Tadpole like morphology.
- Rhabdomyoblasts: Essentially diagnostic cells with eccentric nucleus and Moderate amount of intensely eosinophilic cytoplasm.
Botryoid Rhabdomyosarcoma
- Non-proliferating layer deep to the surface called "Cambium layer".
- Cambium layer is defined as cellular region deep to epithelial component.