Rhabdomyosarcoma pathophysiology: Difference between revisions
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| [[Image:800px-Alveolar rhabdomyosarcoma - intermed mag.jpg|thumb|350px|Alveolar RMS - intermediate magnification]] | | [[Image:800px-Alveolar rhabdomyosarcoma - intermed mag.jpg|thumb|350px|Alveolar RMS - intermediate magnification]] | ||
| [[Image:800px-Alveolar rhabdomyosarcoma - very high mag.jpg|thumb|350px|Alveolar RMS - high magnification]] | | [[Image:800px-Alveolar rhabdomyosarcoma - very high mag.jpg|thumb|350px|Alveolar RMS - high magnification]] | ||
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====Embryonal Rhabdomyosarcoma==== | |||
*Randomly arranged small cells | |||
*Myxoid matrix | |||
*Strap cells: Tadpole like morphology | |||
*Rhabdomyoblasts: Essentially diagnostic cells with [[Nucleus|eccentric nucleus]] and Moderate amount of intensely eosinophilic cytoplasm | |||
==References== | ==References== |
Revision as of 15:31, 1 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Microscopic Pathology
Characteristic features on microscopic analysis are variable depending on the chondrosarcoma subtype:
Alveolar Rhabdomyosarcoma
- Characterized by Alveolus-like pattern
- Fibrous septae lined by tumor cells
- Cells may "fall-off" the septa, i.e. be detached/scattered in the alveolus-like space
- Space between fibrous septae may be filled with tumor, called solid variant of alveolar rhabdomyosarcoma
- Rhabdomyoblasts: Essentially diagnostic cells with eccentric nucleus and Moderate amount of intensely eosinophilic cytoplasm
- Nuclear pleomorphism
- Mitoses
Embryonal Rhabdomyosarcoma
- Randomly arranged small cells
- Myxoid matrix
- Strap cells: Tadpole like morphology
- Rhabdomyoblasts: Essentially diagnostic cells with eccentric nucleus and Moderate amount of intensely eosinophilic cytoplasm