Uterine cancer staging: Difference between revisions
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Most endometrial cancers are [[carcinoma]]s (usually [[adenocarcinoma]]s), meaning that they originate from the single layer of [[epithelium|epithelial]] cells which line the endometrium and form the endometrial glands. There are many [[histopathology|microscopic]] subtypes of ''endometrial carcinoma'', including the common ''endometrioid'' type, in which the cancer cells grow in patterns reminiscent of normal endometrium, and the far more aggressive ''papillary serous'' and ''clear cell'' endometrial carcinomas. Some authorities have proposed that endometrial carcinomas be classified into two pathogenetic groups:<ref>{{cite journal |author=Bokhman JV |title=Two pathogenetic types of endometrial carcinoma |journal=Gynecol. Oncol. |volume=15 |issue=1 |pages=10-7 |year=1983 |pmid=6822361 |doi=}}</ref> | |||
====Type I:==== | |||
These cancers occur most commonly in pre- and peri-[[menopause|menopausal]] women, often with a history of unopposed [[estrogen]] exposure and/or [[endometrial hyperplasia]]. They are often minimally invasive into the underlying uterine wall, are of the ''[[Grading (tumors)|low-grade]] endometrioid'' type, and carry a good prognosis. | |||
====Type II:==== | |||
These cancers occur in older, post-menopausal women, are more common in African-Americans, and are not associated with increased exposure to estrogen. They are typically of the ''[[Grading (tumors)|high-grade]] endometrioid'', ''papillary serous'' or ''clear cell'' types, and carry a generally poor prognosis | |||
In contrast to ''endometrial carcinomas'', the uncommon ''endometrial stromal [[sarcomas]]'' are cancers which originate in the non-glandular [[connective tissue]] of the endometrium. ''Malignant mixed müllerian tumor'' is a rare endometrial cancer which contains cancerous cells of both glandular and [[connective tissue]] appearance - in this case, the cell of origin is unknown.<ref name="Weidner's">{{cite book |author=Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) |title=Modern Surgical Pathology (2 Volume Set) |publisher=W B Saunders |location=London |year= |pages= |isbn=0-7216-7253-1 |oclc= |doi=}}</ref> | |||
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Revision as of 15:02, 1 September 2015
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Most endometrial cancers are carcinomas (usually adenocarcinomas), meaning that they originate from the single layer of epithelial cells which line the endometrium and form the endometrial glands. There are many microscopic subtypes of endometrial carcinoma, including the common endometrioid type, in which the cancer cells grow in patterns reminiscent of normal endometrium, and the far more aggressive papillary serous and clear cell endometrial carcinomas. Some authorities have proposed that endometrial carcinomas be classified into two pathogenetic groups:[1]
Type I:
These cancers occur most commonly in pre- and peri-menopausal women, often with a history of unopposed estrogen exposure and/or endometrial hyperplasia. They are often minimally invasive into the underlying uterine wall, are of the low-grade endometrioid type, and carry a good prognosis.
Type II:
These cancers occur in older, post-menopausal women, are more common in African-Americans, and are not associated with increased exposure to estrogen. They are typically of the high-grade endometrioid, papillary serous or clear cell types, and carry a generally poor prognosis
In contrast to endometrial carcinomas, the uncommon endometrial stromal sarcomas are cancers which originate in the non-glandular connective tissue of the endometrium. Malignant mixed müllerian tumor is a rare endometrial cancer which contains cancerous cells of both glandular and connective tissue appearance - in this case, the cell of origin is unknown.[2] Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.