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| Standard treatment options:Stage I Endometrial Cancer
| | :Stage I Endometrial Cancer |
| | | Standard treatment options: |
| A total hysterectomy and bilateral salpingo-oophorectomy should be done if the tumor: | | A total hysterectomy and bilateral salpingo-oophorectomy should be done if the tumor: |
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| Has less than a 50% myometrial invasion. | | Has less than a 50% myometrial invasion. |
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| Selected pelvic lymph nodes may be removed. If they are negative, no postoperative treatment is indicated. Postoperative treatment with a vaginal cylinder is advocated by some clinicians.[8] | | Selected pelvic lymph nodes may be removed. If they are negative, no postoperative treatment is indicated. Postoperative treatment with a vaginal cylinder is advocated by some clinicians. |
| Preoperative evaluation should include a complete medical history and physical examination, pelvic examination and rectal examination with [[stool guaiac test]], chest X-ray, complete blood count, and blood chemistry tests, including liver function tests.
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| Total [[extrafascial]] [[hysterectomy]] with bilateral salpingo-oopherectomy with pelvic or [[para-aortic lymph node]] dissection is standard procedure. [[Hysterectomy|Abdominal hysterectomy]] is recommended over [[Hysterectomy|vaginal hysterectomy]] because it affords the opportunity to examine and obtain washings of the abdominal cavity to detect any further evidence of cancer. Complete removal of [[omentum]] is warranted for serous or clear cell variety. If a surgeon happens to palpate and find enlarged pelvic or para-aortic lymph nodes, then their sampling or removal is required.
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| In the operating room, the dissected uterine specimen must be grossly visualized to look for [[myometrial]] invasion. In multicenter series of 403 patients who underwent TAH-BSO, the sensitivity , specificity, positive and negative predictive value of gross assessment of myometrial invasion was found to be 73, 93, 85 and 86% respectively. Frozen section of area of invasion is a good practice but it has not shown consistent results.
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| ===When to resect lymph nodes?===
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| If the following are present-
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| *Serous, clear cell or high grade tumor.
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| *Myometrial invasion >50%
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| *Large tumor ,i.e >2cm in diameter.
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| ===Pelvic lymph node dissection===
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| Removal of nodes from distal half of each of [[common iliac]] artery, proximal half of [[external iliac]] artery and vein and distal half of [[obturator fat]] pad.
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| ===Para-aortic lymph node dissection===
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| Removal of nodes from distal [[inferior vena cava]]. These lymph nodes may be positive even if pelvic are not. Hence there has been some survival benefit in females with immediate or high risk disease from dissection of para-aortic group.
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| It is still controversial whether to go for just lymph node sampling or dissection. Even if the surgeon does sampling, it has to be done from multiple sites of lymph node groups draining the uterus. It is vital for surgical staging purposes to have atleast lymph node sampling done during surgery, if not dissection.
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| Risk of [[lymphedema]] increases as more lymph nodes are resected (>10 is associated with a risk of lymphedema of 3-10%). So, it is logical to have risk versus benefit assessment before going for dissection.
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| [[Lymphovascular]] invasion predicts well whether the cancer has spread to the [[parametrium]] or not. Earlier, the spread of endometrial cancer to the cervix was considered to be a sign of parametrial extension and patients had undergone radical hysterectomy. With this knowledge, one can now have [[simple hysterectomy]] in stage II cancer.
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| ===Newer surgical approaches===
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| *Laparoscopy- There are fewer intra-operative complications and shorter duration of hospital stay. Laparoscopic surgery is safe and feasible. However, it is a lengthy procedure, it is difficult to resect para-aortic nodes and effectiveness does not significantly differ when compared to surgery.
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| *Robot-assisted laparoscopy — There is less chance of hemorrhage compared to [[laparotomy]] and laparoscopy. It suffers a similar setback as laparoscopy in operation time being longer than laparotomy.
| | Stage II Endometrial Cancer |
| | Standard treatment options: |
| | If cervical involvement is documented, options include radical hysterectomy, bilateral salpingo-oophorectomy, and pelvic and para-aortic lymph node dissection. |
| | If the cervix is clinically uninvolved but extension to the cervix is documented on postoperative pathology, radiation therapy should be considered. |
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| ==Radiation Therapy== | | ==Radiation Therapy== |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shankar Kumar, M.B.B.S. [2]]
Overview
Surgery
- Stage I Endometrial Cancer
Standard treatment options:
A total hysterectomy and bilateral salpingo-oophorectomy should be done if the tumor:
Is well or moderately differentiated.
Involves the upper 66% of the corpus.
Has negative peritoneal cytology.
Is without vascular space invasion.
Has less than a 50% myometrial invasion.
Selected pelvic lymph nodes may be removed. If they are negative, no postoperative treatment is indicated. Postoperative treatment with a vaginal cylinder is advocated by some clinicians.
Stage II Endometrial Cancer
Standard treatment options:
If cervical involvement is documented, options include radical hysterectomy, bilateral salpingo-oophorectomy, and pelvic and para-aortic lymph node dissection.
If the cervix is clinically uninvolved but extension to the cervix is documented on postoperative pathology, radiation therapy should be considered.
Radiation Therapy
Women with stage 1 disease who are at increased risk for recurrence and those with stage 2 disease are often offered surgery in combination with radiation therapy.
References
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