Follicular lymphoma overview: Difference between revisions
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==Overview== | ==Overview== | ||
Follicular lymphoma is defined as a [[lymphoma]] of [[lymph follicle|follicle]] center [[B-cells]] (centrocytes and centroblasts), which has at least a partially follicular pattern. Follicular lymphoma may be caused by [[translocation]] between [[chromosome]] 14 and 18 that results in the over expression of the [[bcl-2]] gene. The progression to follicular lymphoma involves the microRNAs (miRNAs). Follicular lymphoma may be classified according to WHO criteria into 3 groups: low grade follicular lymphoma, high grade follicular lymphoma and diffuse large B cell lymphoma. Pediatric-type follicular lymphoma, primary intestinal follicular lymphoma, other extranodal follicular lymphomas and follicular lymphoma “in situ” (FLIS) are the other variants that are included under follicular lymphoma. Follicular lymphoma must be differentiated from other diseases such as diffuse large B cell lymphoma, Mucosa-Associated Lymphatic Tissue lymphoma(MALT), small cell lymphocytic lymphoma, and mantle cell lymphoma (MCL). The prevalence of follicular lymphoma increases with age. Women are more commonly affected. | |||
==Classification== | |||
Follicular lymphoma may be classified according to WHO criteria into 3 groups: low grade follicular lymphoma, high grade follicular lymphoma and diffuse large B cell lymphoma. Pediatric-type follicular lymphoma, primary intestinal follicular lymphoma, other extranodal follicular lymphomas and follicular lymphoma “in situ” (FLIS) are the other variants that are included under follicular lymphoma. | |||
==Pathophysiology== | |||
Follicular lymphoma is defined as a [[lymphoma]] of [[lymph follicle|follicle]] center [[B-cells]] (centrocytes and centroblasts), which has at least a partially follicular pattern. Genes involved in the pathogenesis of follicular lymphoma include [[bcl-2]], and bcl-6. The progression to follicular lymphoma involves the microRNAs (miRNAs). | |||
==Causes== | |||
Follicular lymphoma may be caused by [[translocation]] between [[chromosome]] 14 and 18 that results in the over expression of the [[bcl-2]] gene. | |||
==Differential diagnosis== | |||
Follicular lymphoma must be differentiated from other diseases such as diffuse large B cell lymphoma, Mucosa-Associated Lymphatic Tissue lymphoma(MALT), small cell lymphocytic lymphoma, and mantle cell lymphoma (MCL). | |||
==Epidemiology and demographics== | |||
The prevalence of follicular lymphoma increases with age. Women are more commonly affected. | |||
==References== | ==References== | ||
Revision as of 20:42, 25 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Follicular lymphoma is defined as a lymphoma of follicle center B-cells (centrocytes and centroblasts), which has at least a partially follicular pattern. Follicular lymphoma may be caused by translocation between chromosome 14 and 18 that results in the over expression of the bcl-2 gene. The progression to follicular lymphoma involves the microRNAs (miRNAs). Follicular lymphoma may be classified according to WHO criteria into 3 groups: low grade follicular lymphoma, high grade follicular lymphoma and diffuse large B cell lymphoma. Pediatric-type follicular lymphoma, primary intestinal follicular lymphoma, other extranodal follicular lymphomas and follicular lymphoma “in situ” (FLIS) are the other variants that are included under follicular lymphoma. Follicular lymphoma must be differentiated from other diseases such as diffuse large B cell lymphoma, Mucosa-Associated Lymphatic Tissue lymphoma(MALT), small cell lymphocytic lymphoma, and mantle cell lymphoma (MCL). The prevalence of follicular lymphoma increases with age. Women are more commonly affected.
Classification
Follicular lymphoma may be classified according to WHO criteria into 3 groups: low grade follicular lymphoma, high grade follicular lymphoma and diffuse large B cell lymphoma. Pediatric-type follicular lymphoma, primary intestinal follicular lymphoma, other extranodal follicular lymphomas and follicular lymphoma “in situ” (FLIS) are the other variants that are included under follicular lymphoma.
Pathophysiology
Follicular lymphoma is defined as a lymphoma of follicle center B-cells (centrocytes and centroblasts), which has at least a partially follicular pattern. Genes involved in the pathogenesis of follicular lymphoma include bcl-2, and bcl-6. The progression to follicular lymphoma involves the microRNAs (miRNAs).
Causes
Follicular lymphoma may be caused by translocation between chromosome 14 and 18 that results in the over expression of the bcl-2 gene.
Differential diagnosis
Follicular lymphoma must be differentiated from other diseases such as diffuse large B cell lymphoma, Mucosa-Associated Lymphatic Tissue lymphoma(MALT), small cell lymphocytic lymphoma, and mantle cell lymphoma (MCL).
Epidemiology and demographics
The prevalence of follicular lymphoma increases with age. Women are more commonly affected.