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From initial onset, Merkel cell cancer [[metastasize]]s quickly and spreads to other parts of the body, tending towards the regional [[lymph nodes]]. The tumor tends to invade underlying subcutaneous [[Adipose tissue|fat]], [[fascia]], and [[muscle]]. It can also metastasize to the [[liver]], [[lungs]], [[brain]] or [[bone]]s.
From initial onset, Merkel cell cancer [[metastasize]]s quickly and spreads to other parts of the body, tending towards the regional [[lymph nodes]]. The tumor tends to invade underlying subcutaneous [[Adipose tissue|fat]], [[fascia]], and [[muscle]]. It can also metastasize to the [[liver]], [[lungs]], [[brain]] or [[bone]]s.
==Historical Perspective==
==Historical Perspective==
Merkel cell polyomavirus, the pathogen responsible for Merkel cell cancer, was first discovered in 2008.<ref name="pmid23217622">{{cite journal| author=Spurgeon ME, Lambert PF| title=Merkel cell polyomavirus: a newly discovered human virus with oncogenic potential. | journal=Virology | year= 2013 | volume= 435 | issue= 1 | pages= 118-30 | pmid=23217622 | doi=10.1016/j.virol.2012.09.029 | pmc=PMC3522868 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23217622  }} </ref>
==Classification==
==Classification==
Mercell cell carcinoma is classified into 3 subgroups: trabecular, intermediate, and small cell.
==Pathophysiology==
==Pathophysiology==
==Causes==
==Causes==
Merkel cell cancer is caused by Merkel cell polyomavirus (MCV) infection.
==Differential Diagnosis==
==Differential Diagnosis==
Merkel cell cancer must be differentiated from other skin lesions, such as [[basal cell carcinoma]], [[squamous cell carcinoma]], [[malignant melanoma]], [[lymphoma]], vascular tumors, and other benign skin tumors.
==Epidemiology and Demographics==
==Epidemiology and Demographics==
The incidence of Merkel cell carcinoma ranges from 0.15 to 0.44 per 100,000 individuals. The median age at diagnosis is approximately 65 years. Merkel cell carcinoma is more common among males and individuals of Caucasian race.
==Risk Factors==
==Risk Factors==
Risk factors for the development of Merkel cell cancer include old age, male gender, Caucasian race, chronic exposure to sunlight, immunodeficiency, and personal history of cancer.
==Screening==
==Screening==
Screening for Merkel cell cancer is not recommended.
==Natural History, Complications and Prognosis==
==Natural History, Complications and Prognosis==
Merkel cell carcinoma is a highly aggressive tumor with a mortality rate that approaches 30% to 40% within 3 years of diagnosis. If diagnosed early, Merkel cell cancer has a good prognosis with a 5-year survival rate of approximately 90%.
==Diagnosis==
==Diagnosis==
===Staging===
===Staging===

Revision as of 02:03, 21 August 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Merkel cell cancer is a rare and highly aggressive cancer where malignant cancer cells develop on or just beneath the skin and in hair follicles. This cancer is a type of neuroendocrine tumor, like small cell lung cancer. Merkel cell carcinoma is the most serious form of skin cancer. Once it has metastasized to the lymph nodes, the 5-year survival rate for a patient is about 50 percent. A small tumor (less than 2 cm) that has not metastasized to the lymph nodes reported a 5-year survival rate of more than 90 percent; however, at the time of diagnosis of MCC the 5-year survival was 64 percent. Recurrence can occur in up to half of all patients. [1]

It occurs most often on the face, head, and neck. It usually appears as firm, painless, nodules, or tumors. These flesh-colored, red, or blue tumors vary in size from 5 mm (less than a quarter of an inch) to more than 5cm (2 inches). The tumor grows rapidly. About half of all Merkel cell cancers occur on the sun-exposed areas of the head and neck, while one-third begin on the legs, and 15% occur on the arms. The cancer may also begin on other parts of the body, such as the trunk.

From initial onset, Merkel cell cancer metastasizes quickly and spreads to other parts of the body, tending towards the regional lymph nodes. The tumor tends to invade underlying subcutaneous fat, fascia, and muscle. It can also metastasize to the liver, lungs, brain or bones.

Historical Perspective

Merkel cell polyomavirus, the pathogen responsible for Merkel cell cancer, was first discovered in 2008.[2]


Classification

Mercell cell carcinoma is classified into 3 subgroups: trabecular, intermediate, and small cell.

Pathophysiology

Causes

Merkel cell cancer is caused by Merkel cell polyomavirus (MCV) infection.

Differential Diagnosis

Merkel cell cancer must be differentiated from other skin lesions, such as basal cell carcinoma, squamous cell carcinoma, malignant melanoma, lymphoma, vascular tumors, and other benign skin tumors.

Epidemiology and Demographics

The incidence of Merkel cell carcinoma ranges from 0.15 to 0.44 per 100,000 individuals. The median age at diagnosis is approximately 65 years. Merkel cell carcinoma is more common among males and individuals of Caucasian race.

Risk Factors

Risk factors for the development of Merkel cell cancer include old age, male gender, Caucasian race, chronic exposure to sunlight, immunodeficiency, and personal history of cancer.

Screening

Screening for Merkel cell cancer is not recommended.

Natural History, Complications and Prognosis

Merkel cell carcinoma is a highly aggressive tumor with a mortality rate that approaches 30% to 40% within 3 years of diagnosis. If diagnosed early, Merkel cell cancer has a good prognosis with a 5-year survival rate of approximately 90%.

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

CT

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

References

  1. Allen PJ, Browne WB, Jaques DP; et al. (2005). "Merkel cell carcinoma: Prognosis and treatment of patients from a single institution". Journal of Clinical Oncology. 23 (10): 2300–2309.
  2. Spurgeon ME, Lambert PF (2013). "Merkel cell polyomavirus: a newly discovered human virus with oncogenic potential". Virology. 435 (1): 118–30. doi:10.1016/j.virol.2012.09.029. PMC 3522868. PMID 23217622.


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