Merkel cell cancer classification: Difference between revisions

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* Small cell: diffuse, few high density granules on ultrasound examination (second most common).
* Small cell: diffuse, few high density granules on ultrasound examination (second most common).
==Staging==
==Staging==
* According to the [TNM staging system], there are four stages of Merkel cell carcinoma based on the tumor size, presence of lymph nodes and metastasis. Each stage is assigned a letter/number.
* The stages of Merkel cell carcinoma are shown in the table below:
{| {{table}}
{| {{table}}
| align="center" style="background:#f0f0f0;"|'''Stage'''
| align="center" style="background:#f0f0f0;"|'''Stage'''
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|  IV||Any size tumor (includes invading tumors)||Any lymph node metastasis||Metastasis beyond regional lymph nodes
|  IV||Any size tumor (includes invading tumors)||Any lymph node metastasis||Metastasis beyond regional lymph nodes
|}
|}
==References==
==References==



Revision as of 13:27, 20 August 2015

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Classification

Histologically, MCC has been classified into three distinct subtypes:

  • Trabecular: classic pattern, large-cell type, high density or granules on ultrasound examination.
  • Intermediate: solid pattern (most common).
  • Small cell: diffuse, few high density granules on ultrasound examination (second most common).

Staging

  • According to the [TNM staging system], there are four stages of Merkel cell carcinoma based on the tumor size, presence of lymph nodes and metastasis. Each stage is assigned a letter/number.
  • The stages of Merkel cell carcinoma are shown in the table below:
Stage Primary Tumor Lymph Node Metastasis
0 In situ primary tumor No regional lymph node metastasis No distant metastasis
IA Less than or equal to 2 cm maximum tumor dimension Nodes negative by pathologic exam No distant metastasis
IB Less than or equal to 2 cm maximum tumor dimension Nodes negative by clinical exam* (no pathologic node exam performed) No distant metastasis
IIA Greater than 2 cm tumor dimension Nodes negative by pathologic exam No distant metastasis
IIB Greater than 2 cm tumor dimension Nodes negative by clinical exam* (no pathologic node exam performed) No distant metastasis
IIC Primary tumor invades bone, muscle, fascia, or cartilage No regional lymph node metastasis No distant metastasis
IIIA Any size tumor (includes invading tumors) Micrometastasis** No distant metastasis
IIIB Any size tumor (includes invading tumors) "Macrometastasis*** -OR- In transit metastasis****" No distant metastasis
IV Any size tumor (includes invading tumors) Any lymph node metastasis Metastasis beyond regional lymph nodes

References