Aortitis medical therapy: Difference between revisions
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:* Preferred regimen (4): [[Vancomycin]] 1.0 g (15 mg/kg, up to 3.0 to 4.0 g/d) IV q12h | :* Preferred regimen (4): [[Vancomycin]] 1.0 g (15 mg/kg, up to 3.0 to 4.0 g/d) IV q12h | ||
:* Note: Antimicrobial treatments are most effective when bactericidal, broadspectrum [[antibiotics]] are begun after obtaining [[blood cultures]] and prior to [[surgery]]. Dose of [[Cefotaxime sodium]] should be decreased by 50% in those with a [[creatinine]] clearance (CCr) of ≤ 20 mL/min. [[Ciprofloxacin]] should be used cautiously in those with a CCr ≤ 50 mL/min or when given concomitantly with drugs whose metabolism may be altered. | :* Note: Antimicrobial treatments are most effective when bactericidal, broadspectrum [[antibiotics]] are begun after obtaining [[blood cultures]] and prior to [[surgery]]. Dose of [[Cefotaxime sodium]] should be decreased by 50% in those with a [[creatinine]] clearance (CCr) of ≤ 20 mL/min. [[Ciprofloxacin]] should be used cautiously in those with a CCr ≤ 50 mL/min or when given concomitantly with drugs whose metabolism may be altered. | ||
==References== | |||
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Revision as of 20:43, 11 August 2015
Aortitis, infectious
- Preferred regimen[1](1): Cefotaxime sodium 1.0 to 2.0 g IV qd
- Preferred regimen (2): Ciprofloxacin hydrochloride 400 mg IV q12h OR Ciprofloxacin hydrochloride 500 to 750 mg PO q12h OR Levofloxacin 250 to 750 mg IV/PO qd
- Preferred regimen (3): Oxacillin 1.0 to 2.0g IV or IM q4h / q6h OR Nafcillin 1.0 to 2.0 g IV or IM q4h / q6h OR Dicloxacillin 500 mg to 1.0 g IV or IM q4h /q6h
- Preferred regimen (4): Vancomycin 1.0 g (15 mg/kg, up to 3.0 to 4.0 g/d) IV q12h
- Note: Antimicrobial treatments are most effective when bactericidal, broadspectrum antibiotics are begun after obtaining blood cultures and prior to surgery. Dose of Cefotaxime sodium should be decreased by 50% in those with a creatinine clearance (CCr) of ≤ 20 mL/min. Ciprofloxacin should be used cautiously in those with a CCr ≤ 50 mL/min or when given concomitantly with drugs whose metabolism may be altered.
References
- ↑ Foote EA, Postier RG, Greenfield RA, Bronze MS (2005). "Infectious Aortitis". Curr Treat Options Cardiovasc Med. 7 (2): 89–97. PMID 15935117.