| elimination_half-life = ~10 - 25 minutes <ref>Ehrsson H, Wallin I, Yachnin J. ''Medical Oncology''. 2002; '''19''':251-265.</ref>
| pregnancy_category =
| legal_status =
| routes_of_administration = Intravenous
| excretion = Renal }}
{{SI}}
* Content
==Overview==
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'''Oxaliplatin''' is a [[platinum]]-based [[chemotherapy]] [[medication|drug]] in the same family as [[cisplatin]] and [[carboplatin]]. It is typically administered in combination with [[fluorouracil]] and [[leucovorin]] in a combination known as [[FOLFOX]] for the treatment of [[colorectal cancer]]. Compared to cisplatin the two [[amine]] groups are replaced by cyclohexyldiamine for improved antitumour activity. The chlorine ligands are replaced by the oxalato [[bidentate]] derived from [[oxalic acid]] in order to improve water solubility.
Oxaliplatin is marketed by [[Sanofi-Aventis]] under the trademark '''Eloxatin'''®.
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== Mechanism of action and efficacy ==
* Dosing Information
The exact mechanism of action of oxaliplatin is not known. In vivo studies showed oxaliplatin has anti-tumor activity against colon carcinoma through its (non-targeted) [[cytotoxic]] effects. Median patient survival is approximately 5 months greater compared to the previous standard treatment.
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== Side-effects ==
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Side-effects of oxaliplatin treatment can potentially include:
* [[Neuropathy]], (both an acute, reversible sensitivity to cold and numbness in the hands and feet and a chronic, possibly irreversible foot/leg, hand/arm numbness, often with deficits in [[proprioception]])<ref name=pasetto>Pasetto LM, D'Andrea MR, Rossi E, Monfardini S. Oxaliplatin-related neurotoxicity: how and why? Crit Rev Oncol Hematol. 2006 Aug;59(2):159-68. Epub 2006 Jun 27. PMID 16806962.</ref>
* [[Fatigue (physical)|Fatigue]]
* [[Nausea]], [[vomiting]], and/or [[diarrhea]]
* [[Neutropenia]]
* [[Ototoxicity]] (hearing loss)
In addition, some patients may experience an [[allergy|allergic reaction]] to platinum-containing drugs.
* Dosing Information
Oxaliplatin has less ototoxicity and [[nephrotoxicity]] than cisplatin and carboplatin.<ref name=pasetto/>
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==History==
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Oxaliplatin was discovered in 1976 at Nagoya City University in Japan by Professor Yoshinori Kidani, who was granted U.S. Patent 4,169,846 over the drug in 1979. Oxaliplatin was subsequently in-licensed by Debiopharm, a Swiss drug company headquartered in Lausanne and developed as an advanced colorectal cancer treatment. Debio licensed the drug to [[Sanofi-Aventis]] in 1994. Eloxatin gained European approval in 1999 and [[FDA]] approval in 2004.
== Patent information ==
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Eloxatin is covered by patent numbers 5338874 (Expiry Apr 07,2013), 5420319 (Expiry Aug 08,2016), 5716988 (Expiry Aug 07,2015) and 5290961 (Expiry Jan 12, 2013) (see Electronic Orange Book patent info for Eloxatin).<ref name=021759>Orange Book. accessdata.fda.gov. URL: [http://www.accessdata.fda.gov/scripts/cder/ob/docs/patexclnew.cfm?Appl_No=021759&Product_No=001&table1=OB_Rx http://www.accessdata.fda.gov/scripts/cder/ob/docs/patexclnew.cfm?Appl_No=021759&Product_No=001&table1=OB_Rx]. Accessed on: July 22, 2007.</ref> Exclusivity code I-441, which expires on Nov 04, 2007, is for use combination with infusional 5-FU/LV for adjuvant treatment stage III colon cancer patients who have undergone complete resection primary tumor-based on improvement in disease free survival with no demonstrated benefit overall survival after 4 years. Exclusivity code NCE, New Chemical Entity, expires on Aug 09, 2007.<ref name=021759/>
== References ==
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<references/>
==Additional sources==
=====Condition4=====
* {{cite journal | author = Graham J, Mushin M, Kirkpatrick P | title = Oxaliplatin. | journal = Nat Rev Drug Discov | volume = 3 | issue = 1 | pages = 11-2 | year = 2004 | id = PMID 14756144 | url=http://www.dresources.com/nature/ntr_0104.pdf | format=PDF}}
==External links==
* Dosing Information
* [http://www.eloxatin.com Eloxatin] - web site of manufacturer.
* [http://www.virtualcancercentre.com/drugs.asp?drugid=1777 Virtual Cancer Centre: Oxaliplatin/Eloxatin]
* [http://www.cancer.gov/cancertopics/druginfo/oxaliplatin NCI Drug Information Summary on Oxaliplatin]
{{Chemotherapeutic agents}}
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[[Category:Chemotherapeutic agents]]
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[[Category:Platinum compounds]]
[[Category:Coordination compounds]]
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[[ru:Оксалиплатин]]
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Overview
Oxaliplatin is a {{{drugClass}}} that is FDA approved for the {{{indicationType}}} of {{{indication}}}. There is a Black Box Warning for this drug as shown here. Common adverse reactions include .
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Off-Label Use and Dosage (Adult)
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There is limited information regarding Off-Label Non–Guideline-Supported Use of Oxaliplatin in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
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Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
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Cardiovascular
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Neurologic
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Postmarketing Experience
There is limited information regarding Postmarketing Experience of Oxaliplatin in the drug label.