Silver sulfadiazine: Difference between revisions

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{{DrugProjectFormSinglePage
{{Silver sulfadiazine}}
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==Overview==
* Content


'''Silver sulfadiazine''' ([[International Nonproprietary Name|INN]], or '''silvadene''') is a [[topical]] [[sulfonamide (medicine)|sulfonamide]]/[[silver]]<ref name="pmid14512929">{{cite journal |author=Fisher NM, Marsh E, Lazova R |title=Scar-localized argyria secondary to silver sulfadiazine cream |journal=J. Am. Acad. Dermatol. |volume=49 |issue=4 |pages=730–2 |year=2003 |month=October |pmid=14512929 |doi= 10.1067/S0190-9622(02)61574-9|url=http://linkinghub.elsevier.com/retrieve/pii/S0190962202615749}}</ref> [[antibacterial]] used as a topical cream on [[burn]]s. Studies have found that silver sulfadiazine may increase healing times; and it is therefore not recommended by the authors of a [[Cochrane review]].<ref>{{cite journal |author=Wasiak J, Cleland H, Campbell F |title=Dressings for superficial and partial thickness burns |journal=Cochrane Database Syst Rev |volume= |issue=4 |pages=CD002106 |year=2008|pmid=18843629 |doi=10.1002/14651858.CD002106.pub3 |quote=The use of silver sulphadiazine (SSD) as a comparator on burn wounds for the full duration of treatment needs to be reconsidered, as a number of studies showed delays in time to wound healing and increased number of dressing applications in patients treated with SSD dressings}}</ref>
<!--Adult Indications and Dosage-->


Silver sulfadiazine is typically delivered in a 1% [[cream (pharmaceutical)|cream]] or [[aqueous]] [[suspension (chemistry)|suspension]]. Brand names include '''Silvadene''' (a [[genericized trademark]]), '''Silverex''', '''Silverol,''' '''Silvazine''', '''Flamazine''', '''Thermazene''', '''BurnHeal''', and '''SSD'''.<ref>http://www.drugs.com/mtm/ssd.html This source names Silvadene, SSD, SSD AF, Thermazene</ref>
<!--FDA-Labeled Indications and Dosage (Adult)-->
|fdaLIADAdult======Condition1=====


==Category==
* Dosing Information


==US Brand Names==
:* Dosage
SILVER SULFADIAZENE<sup>®</sup>


==FDA Package Insert==
=====Condition2=====


'''  [[Silver sulfadiazine description|Description]]'''
* Dosing Information
'''| [[Silver sulfadiazine clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Silver sulfadiazine microbiology|Microbiology]]'''
'''| [[Silver sulfadiazine indications and usage|Indications and Usage]]'''
'''| [[Silver sulfadiazine contraindications|Contraindications]]'''
'''| [[Silver sulfadiazine warnings and precautions|Warnings and Precautions]]'''
'''| [[Silver sulfadiazine adverse reactions|Adverse Reactions]]'''
'''| [[Silver sulfadiazine drug interactions|Drug Interactions]]'''
'''| [[Silver sulfadiazine overdosage|Overdosage]]'''
'''| [[Silver sulfadiazine clinical studies|Clinical Studies]]'''
'''| [[Silver sulfadiazine dosage and administration|Dosage and Administration]]'''
'''| [[Silver sulfadiazine how supplied|How Supplied]]'''
'''| [[Silver sulfadiazine labels and packages|Labels and Packages]]'''


==Mechanism of Action==
:* Dosage


==References==
=====Condition3=====
{{Reflist|2}}


[[Category:Antibiotics]]
* Dosing Information
[[Category:Wikinfect]]
 
:* Dosage
 
=====Condition4=====
 
* Dosing Information
 
:* Dosage
 
<!--Off-Label Use and Dosage (Adult)-->
 
<!--Guideline-Supported Use (Adult)-->
|offLabelAdultGuideSupport======Condition1=====
 
* Developed by:
 
* Class of Recommendation:
 
* Strength of Evidence:
 
* Dosing Information
 
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* Dosing Information
 
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<!--Pediatric Indications and Dosage-->
 
<!--FDA-Labeled Indications and Dosage (Pediatric)-->
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* Dosing Information
 
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There is limited information regarding <i>FDA-Labeled Use</i> of {{PAGENAME}} in pediatric patients.
 
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* Class of Recommendation:
 
* Strength of Evidence:
 
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* Dosing Information
 
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<!--Contraindications-->
|contraindications=* Condition1
 
<!--Warnings-->
|warnings=* Description
 
====Precautions====
 
* Description
 
<!--Adverse Reactions-->
 
<!--Clinical Trials Experience-->
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=====Body as a Whole=====
 
 
 
 
=====Cardiovascular=====
 
 
 
 
=====Digestive=====
 
 
 
 
=====Endocrine=====
 
 
 
 
=====Hematologic and Lymphatic=====
 
 
 
 
=====Metabolic and Nutritional=====
 
 
 
 
=====Musculoskeletal=====
 
 
 
 
=====Neurologic=====
 
 
 
 
=====Respiratory=====
 
 
 
 
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=====Special Senses=====
 
 
 
 
=====Urogenital=====
 
 
 
 
=====Miscellaneous=====
 
 
 
<!--Postmarketing Experience-->
|postmarketing=There is limited information regarding <i>Postmarketing Experience</i> of {{PAGENAME}} in the drug label.
 
=====Body as a Whole=====
 
 
 
=====Cardiovascular=====
 
 
 
=====Digestive=====
 
 
 
=====Endocrine=====
 
 
 
=====Hematologic and Lymphatic=====
 
 
 
=====Metabolic and Nutritional=====
 
 
 
=====Musculoskeletal=====
 
 
 
=====Neurologic=====
 
 
 
=====Respiratory=====
 
 
 
=====Skin and Hypersensitivy Reactions=====
 
 
 
=====Special Senses=====
 
 
 
=====Urogenital=====
 
 
 
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<!--Administration and Monitoring-->
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[[Category:Drug]]

Revision as of 18:50, 19 January 2015

Silver sulfadiazine
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

Disclaimer

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Black Box Warning

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Silver sulfadiazine is a {{{drugClass}}} that is FDA approved for the {{{indicationType}}} of {{{indication}}}. There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Silver sulfadiazine in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Silver sulfadiazine in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Silver sulfadiazine in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Silver sulfadiazine in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Silver sulfadiazine in pediatric patients.

Contraindications

  • Condition1

Warnings

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Silver sulfadiazine in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Silver sulfadiazine in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Silver sulfadiazine in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Silver sulfadiazine during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Silver sulfadiazine with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Silver sulfadiazine with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Silver sulfadiazine with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Silver sulfadiazine with respect to specific gender populations.

Race

There is no FDA guidance on the use of Silver sulfadiazine with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Silver sulfadiazine in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Silver sulfadiazine in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Silver sulfadiazine in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Silver sulfadiazine in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Silver sulfadiazine in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Silver sulfadiazine in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Silver sulfadiazine in the drug label.

Pharmacology

There is limited information regarding Silver sulfadiazine Pharmacology in the drug label.

Mechanism of Action

Structure

File:Silver sulfadiazine01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Silver sulfadiazine in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Silver sulfadiazine in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Silver sulfadiazine in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Silver sulfadiazine in the drug label.

How Supplied

Storage

There is limited information regarding Silver sulfadiazine Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Silver sulfadiazine |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Silver sulfadiazine |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Silver sulfadiazine in the drug label.

Precautions with Alcohol

  • Alcohol-Silver sulfadiazine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)

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