Aortic stenosis causes: Difference between revisions
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|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular''' | |style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular''' | ||
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | Age-induced calcification | |style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | Age-induced calcification, [[aortic sclerosis]], [[aortitis]], [[bicuspid aortic valve]] or [[Bicuspid aortic stenosis|bicommissural aortic valve]], prosthetic aortic valve, [[hypertrophic cardiomyopathy]], [[Aortic valve#Disease of the aortic valve|hypoplastic aortic annulus]], [[hypoplastic left heart syndrome]], [[idiopathic hypertrophic subaortic stenosis]], [[infective endocarditis]], [[quadricuspid aortic valve]], [[rheumatic fever]], [[Aortic valve#Disease of the aortic valve|tricuspid aortic valve with commissural fushion]] | ||
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| '''Genetic''' | | '''Genetic''' | ||
|bgcolor="Beige"| | |bgcolor="Beige"| [[Williams syndrome]], [[3-Methylglutaconic aciduria|3-methylglutaconic aciduria type 4]], [[alkaptonuria]], [[Bardet-Biedl syndrome]], [[Chromosome 15q partial deletion|chromosome 15q deletion syndromes]], [[Fabry's disease]], [[Familial thoracic aortic aneurysm|familial thoracic aortic aneurysm syndrome]], [[Fryns-Van den Berghe syndrome]], [[homozygous type II hypercholesterolemia]], [[Loeys-Dietz syndrome]], [[Pseudo-Hurler polydystrophy|mucolipidosis III gamma]], [[Onat syndrome]], [[Paget's disease]], [[Singleton-Merten syndrome]], [[Sweet syndrome]], [[Turner syndrome]], [[Aortic valve#Disease of the aortic valve|unicommissural aortic valve]] or [[Aortic valve#Disease of the aortic valve|unicuspid aortic valve]] | ||
[[alkaptonuria]], [[Bardet-Biedl syndrome]], [[Chromosome 15q partial deletion|chromosome 15q deletion syndromes]], [[Fabry's disease]], [[Familial thoracic aortic aneurysm|familial thoracic aortic aneurysm syndrome]], [[Fryns-Van den Berghe syndrome]], [[homozygous type II hypercholesterolemia]], [[Loeys-Dietz syndrome]], [[Pseudo-Hurler polydystrophy|mucolipidosis III gamma]], [[Onat syndrome]], [[Paget's disease]], [[Singleton-Merten syndrome]], [[Sweet syndrome]], [[Turner syndrome]], [[Aortic valve#Disease of the aortic valve|unicommissural aortic valve]] or [[Aortic valve#Disease of the aortic valve|unicuspid aortic valve]] | |||
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| '''Infectious Disease''' | | '''Infectious Disease''' | ||
|bgcolor="Beige"| [[Infective endocarditis]] | |bgcolor="Beige"| [[Infective endocarditis]], [[rheumatic fever]] | ||
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| '''Rheum / Immune / Allergy''' | | '''Rheum / Immune / Allergy''' | ||
|bgcolor="Beige"| [[Rheumatic fever]] | |bgcolor="Beige"| [[Rheumatic fever]], [[systemic lupus erythematosus]] | ||
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Revision as of 15:42, 29 December 2014
Aortic Stenosis Microchapters |
Diagnosis |
---|
Treatment |
Percutaneous Aortic Balloon Valvotomy (PABV) or Aortic Valvuloplasty |
Transcatheter Aortic Valve Replacement (TAVR) |
Case Studies |
Aortic stenosis causes On the Web |
American Roentgen Ray Society Images of Aortic stenosis causes |
Risk calculators and risk factors for Aortic stenosis causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Mohammed A. Sbeih, M.D. [2]; Lakshmi Gopalakrishnan, M.B.B.S. [3]; Vendhan Ramanujam M.B.B.S [4]; Assistant Editor-In-Chief: Kristin Feeney, B.S. [5]
Overview
Aortic stenosis can be either congenital or acquired, and its common causes vary between different age groups and between different populations. Rheumatic heart disease remains the most common cause of aortic stenosis worldwide. Calcification is the most common cause of aortic stenosis in North America;[1] while calcification of congenital bicuspid aortic valve is the most common cause of aortic stenosis in people less than 70 years of age, acquired degenerative calcific aortic stenosis is the most common cause in older patients above the age of 70 years.[2][3]
Causes
Causes of Aortic Stenosis by Location of Stenosis
Valvular Aortic Stenosis
- Acquired [4]
- Congenital [4]
- 3-Methylglutaconic aciduria type 4
- Bardet-Biedl syndrome
- Bicuspid aortic valve
- Chromosome 15q deletion syndromes
- Fabry's disease
- Familial hypercholesterolemia
- Familial thoracic aortic aneurysm syndrome
- Hypoplastic aortic annulus[8]
- Loeys-Dietz syndrome
- Mucolipidosis III gamma
- Onat syndrome
- Quadricuspid aortic valve
- Singleton-Merten syndrome
- Sweet syndrome
- Tricuspid aortic valve with commissural fushion
- Turner syndrome
- Unicuspid aortic valve
Subvalvular Aortic Stenosis
- Familial subvalvular aortic stenosis[9]
- Hypertrophic cardiomyopathy
- Idiopathic hypertrophic subaortic stenosis
Supravalvular Aortic Stenosis
- Aortitis
- Familial supravalvular aortic stenosis[10]
- Homozygous familial hypercholesterolemia[11]
- Hypoplastic left heart syndrome
- Williams syndrome[12]
Causes of Aortic Stenosis by Frequency
According to the Euro Heart Survey[4] on valvular heart disease, the frequencies of the different underlying causes of aortic stenosis were the following:
- Calcific degeneration - 81.9%
- Rheumatic fever - 11.2% [13]
- Congenital - 5.6%
- Post-endocarditis - 1.3%
Causes of Aortic Valve Calcification:
- Aortic stenosis is most commonly caused by age-related progressive calcification of the normal tricuspid aortic valve (>50% of cases).
- Other causes include:
- Calcification of a congenital bicuspid aortic valve (30-40% of cases of calcification)
- Acute rheumatic fever (less than 10% of cases of calcification)
Causes of More Rapid Aortic Stenosis Progression:
- Normal valves have three leaflets (tricuspid), but some valves have only two (bicuspid). Aortic stenosis due to calcification of a bicuspid valve typically becomes symptomatic in the 40s and 50s whereas that due to calcification of a normal valve manifests later in the 70s and 80s. Hypertension, diabetes mellitus, hyperlipoproteinemia and uremia may speed up the process.[13]
Causes of Aortic Stenosis by Age Groups
The cause of aortic stenosis will vary with age:[14][15]
- Under Age 70:
- Bicuspid aortic valve - 50%
- Postinflammatory - 25%
- Degenerative calcific - 18%
- Unicommissural - 3%
- Hypoplastic - 2%
- Indeterminant - 2%
- Over Age 70:
- Degenerative calcific - 48%
- Bicuspid - 27%
- Postinflammatory - 23%
- Hypoplastic - 2%
Complete List of Causes of Aortic Stenosis
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
Common Causes
- Calcific degeneration
- Congenital bicuspid aortic valve
- Infective endocarditis
- Rheumatic fever[1][13]
Causes by Organ System
Causes in Alphabetical Order
References
- ↑ 1.0 1.1 Lugiano, CA. (2013). "Aortic stenosis". JAAPA. 26 (11): 46–7. doi:10.1097/01.JAA.0000436518.69169.8e. PMID 24153092. Unknown parameter
|month=
ignored (help) - ↑ Iung, B.; Baron, G.; Butchart, EG.; Delahaye, F.; Gohlke-Bärwolf, C.; Levang, OW.; Tornos, P.; Vanoverschelde, JL.; Vermeer, F. (2003). "A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease". Eur Heart J. 24 (13): 1231–43. PMID 12831818. Unknown parameter
|month=
ignored (help) - ↑ Roberts, WC.; Ko, JM. (2005). "Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation". Circulation. 111 (7): 920–5. doi:10.1161/01.CIR.0000155623.48408.C5. PMID 15710758. Unknown parameter
|month=
ignored (help) - ↑ 4.0 4.1 4.2 Cleland JG, Swedberg K, Follath F, Komajda M, Cohen-Solal A, Aguilar JC, Dietz R, Gavazzi A, Hobbs R, Korewicki J, Madeira HC, Moiseyev VS, Preda I, van Gilst WH, Widimsky J, Freemantle N, Eastaugh J, Mason J (2003). "The EuroHeart Failure survey programme-- a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis". European Heart Journal. 24 (5): 442–63. PMID 12633546. Retrieved 2012-04-11. Unknown parameter
|month=
ignored (help) - ↑ Hannoush H, Introne WJ, Chen MY, Lee SJ, O'Brien K, Suwannarat P; et al. (2012). "Aortic stenosis and vascular calcifications in alkaptonuria". Mol Genet Metab. 105 (2): 198–202. doi:10.1016/j.ymgme.2011.10.017. PMC 3276068. PMID 22100375.
- ↑ Aronow, WS. (2013). "A review of the pathophysiology, diagnosis, and treatment of aortic valve stenosis in elderly patients". Hosp Pract (1995). 41 (4): 66–77. doi:10.3810/hp.2013.10.1082. PMID 24145591. Unknown parameter
|month=
ignored (help) - ↑ Strickberger SA, Schulman SP, Hutchins GM. Association of Paget’s disease of bone with calcific aortic valve disease. Am J Med 1987;82:953-6.
- ↑ REEVE, R.; ROBINSON, SJ. (1964). "HYPOPLASTIC ANNULUS--AN UNUSUAL TYPE OF AORTIC STENOSIS: A REPORT OF THREE CASES IN CHILDREN". Dis Chest. 45: 99–102. PMID 14114644. Unknown parameter
|month=
ignored (help) - ↑ Stern, JA.; Meurs, KM.; Nelson, OL.; Lahmers, SM.; Lehmkuhl, LB. (2012). "Familial subvalvular aortic stenosis in golden retrievers: inheritance and echocardiographic findings". J Small Anim Pract. 53 (4): 213–6. doi:10.1111/j.1748-5827.2011.01187.x. PMID 22417094. Unknown parameter
|month=
ignored (help) - ↑ Chiarella, F.; Bricarelli, FD.; Lupi, G.; Bellotti, P.; Domenicucci, S.; Vecchio, C. (1989). "Familial supravalvular aortic stenosis: a genetic study". J Med Genet. 26 (2): 86–92. PMID 2918546. Unknown parameter
|month=
ignored (help) - ↑ Giannakoulas, G.; Mouratoglou, SA.; Kelekis, A.; Hatzimiltiades, S.; Karvounis, H. "Supravalvular aortic stenosis in homozygous familial hypercholesterolemia". Hellenic J Cardiol. 54 (5): 392–3. PMID 24100183.
- ↑ Deo, SV.; Burkhart, HM.; Dearani, JA.; Schaff, HV. (2013). "Supravalvar aortic stenosis: current surgical approaches and outcomes". Expert Rev Cardiovasc Ther. 11 (7): 879–90. doi:10.1586/14779072.2013.811967. PMID 23895031. Unknown parameter
|month=
ignored (help) - ↑ 13.0 13.1 13.2 VOC=VITIUM ORGANICUM CORDIS, a compendium of the Department of Cardiology at Uppsala Academic Hospital. By Per Kvidal September 1999, with revision by Erik Björklund May 2008
- ↑ Roberts WC, Vowels TJ, Ko JM. Comparison of interpretations of valve structure between cardiac surgeon and cardiac pathologist among adults having isolated aortic valve replacement for aortic valve stenosis (+/- aortic regurgitation). Am J Cardiol. Apr 15 2009;103(8):1139-45.
- ↑ http://emedicine.medscape.com/article/150638-overview#aw2aab6b2b3aa