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Overview
Diphenhydramine is a Analgesic , Antihistamine that is FDA approved for the treatment of temporarily relieves symptoms of the common cold like
runny nose, sneezing, itchy watery eyes, itchy nose or throat. Common adverse reactions include Xerostomia, dizziness, dyskinesia, sedatation, somnolence
dryness of nasal mucosa, pharyngeal dryness, thick sputum..
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
Temporarily relieves these symptoms due to hay fever or other upper respiratory allergies:
Runny nose
Sneezing
Itchy, watery eyes
Itchy nose or throat
Temporarily relieves these symptoms of the common cold:
Runny nose
Sneezing
Dosing Information
Take every 4 to 6 hours, not more than 6 doses in 24 hours
This image is provided by the National Library of Medicine.
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
Chemotherapy-induced nausea and vomiting.
Extrapyramidal disease - Medication-induced movement disorder.
Hyperemesis gravidarum.
Local anesthesia
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Diphenhydramine in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
Condition1
Dosing Information
Dosage
Condition2
There is limited information regarding FDA-Labeled Use of Diphenhydramine in pediatric patients.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Diphenhydramine in pediatric patients.
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Diphenhydramine in pediatric patients.
Contraindications
Diphenhydramine is contraindicated in persons with known hypersensitivity.
Warnings
Do not use with any other product containing diphenhydramine, even one used on skin
To make a child sleepy
Ask a doctor before use if you have glaucoma
Trouble urinating due to an enlarged prostate gland
A breathing problem such as emphysema or chronic bronchitis
Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers
When using this product
marked drowsiness may occur
avoid alcoholic drinks
excitability may occur, especially in children
alcohol, sedatives and tranquilizers may increase drowsiness
be careful when driving a motor vehicle or operating machinery
If pregnant or breast-feeding,
ask a health professional before use.
Keep out of reach of children.
In case of overdose, get medical help or contact a Poison Control Center right away.
Adverse Reactions
Clinical Trials Experience
Digestive
Xerostomia
Neurologic
Sedation
Dizziness
Dyskinesia
Somnolence
Respiratory
Dryness of nasal mucosa
Pharyngeal dryness
Thick sputum
Bronchial dryness
=Miscellaneous
Anaphylaxis reaction
Postmarketing Experience
There is limited information regarding Postmarketing Experience of Diphenhydramine in the drug label.
Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous
Drug Interactions
There is limited information regarding drug interactions of Diphenhydramine in the drug label.
↑ 3.03.13.2Simons KJ, Watson WT, Martin TJ, Chen XY, Simons FE (July 1990). "Diphenhydramine: pharmacokinetics and pharmacodynamics in elderly adults, young adults, and children". J. Clin. Pharmacol. 30 (7): 665–71. doi:10.1002/j.1552-4604.1990.tb01871.x. PMID2391399.CS1 maint: Multiple names: authors list (link)