Albendazole: Difference between revisions

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==Overview==
Albendazole is a member of the [[benzimidazole]] compounds used as a [[medication|drug]] indicated for the [[Pharmacotherapy|treatment]] of a variety of [[worm]] infestations. Although this use is widespread in the United States, the [[FDA]] has not approved albendazole for this indication.
==Category==
Antiparasitic
==US Brand Names==
ALBENZA<sup>®</sup>
==FDA Package Insert==
'''  [[Albendazole description|Description]]'''
'''| [[Albendazole clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Albendazole microbiology|Microbiology]]'''
'''| [[Albendazole indications and usage|Indications and Usage]]'''
'''| [[Albendazole contraindications|Contraindications]]'''
'''| [[Albendazole warnings and precautions|Warnings and Precautions]]'''
'''| [[Albendazole adverse reactions|Adverse Reactions]]'''
'''| [[Albendazole drug interactions|Drug Interactions]]'''
'''| [[Albendazole overdosage|Overdosage]]'''
'''| [[Albendazole dosage and administration|Dosage and Administration]]'''
'''| [[Albendazole how supplied|How Supplied]]'''
'''| [[Albendazole labels and packages|Labels and Packages]]'''
===Pill Images===
{{TempDrugImages}}
==Mechanism of Action==
Vermicidal: Albendazole ([[Carbon|C]]<sub>12</sub>[[Hydrogen|H]]<sub>15</sub>[[Nitrogen|N]]<sub>3</sub>[[Oxygen|O]]<sub>2</sub>[[Sulphur|S]]) causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the [[colchicine]]-sensitive site of [[tubulin]], thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their [[glycogen]] stores. Degenerative changes in the [[endoplasmic reticulum]], the [[mitochondria]] of the germinal layer, and the subsequent release of [[lysosome]]s result in decreased production of[[adenosine triphosphate]] (ATP), which is the energy required for the survival of the [[helminth]]. Due to diminished energy production, the parasite is immobilized and eventually dies.
Albendazole also has been shown to inhibit the enzyme [[fumarate reductase]], which is helminth-specific. This action may be considered secondary to the effect on the microtubules due to the decreased absorption of glucose. This action occurs in the presence of reduced amounts of nicotinamide-adenine dinucleotide in reduced form (NADH), which is a[[coenzyme]] involved in many cellular oxidation-reduction reactions.
Albendazole has larvicidal effects in [[necatoriasis]] and ovicidal effects in [[ascariasis]], [[ancylostomiasis]], and [[trichuriasis]].
==Uses==
It is effective against:
* [[Pinworm]]s
* [[Roundworm]]s
* [[Whipworm]]s
* [[Tapeworm]]s
* [[Hookworm]]s
==References==
{{Reflist|2}}
[[Category:Antibiotics]]
[[Category:Wikinfect]]

Revision as of 15:28, 8 December 2014

Albendazole
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Adeel Jamil, M.D. [2]

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Overview

Albendazole is {{{aOrAn}}} {{{drugClass}}} that is FDA approved for the {{{indicationType}}} of {{{indication}}}. Common adverse reactions include {{{adverseReactions}}}.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

There is limited information regarding Albendazole FDA-Labeled Indications and Dosage (Adult) in the drug label.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Albendazole in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Albendazole in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding Albendazole FDA-Labeled Indications and Dosage (Pediatric) in the drug label.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Albendazole in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Albendazole in pediatric patients.

Contraindications

There is limited information regarding Albendazole Contraindications in the drug label.

Warnings

There is limited information regarding Albendazole Warnings' in the drug label.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Albendazole Clinical Trials Experience in the drug label.

Postmarketing Experience

There is limited information regarding Albendazole Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Albendazole Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Albendazole in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Albendazole in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Albendazole during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Albendazole in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Albendazole in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Albendazole in geriatric settings.

Gender

There is no FDA guidance on the use of Albendazole with respect to specific gender populations.

Race

There is no FDA guidance on the use of Albendazole with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Albendazole in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Albendazole in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Albendazole in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Albendazole in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Albendazole Administration in the drug label.

Monitoring

There is limited information regarding Albendazole Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Albendazole and IV administrations.

Overdosage

There is limited information regarding Albendazole overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

There is limited information regarding Albendazole Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Albendazole Mechanism of Action in the drug label.

Structure

There is limited information regarding Albendazole Structure in the drug label.

Pharmacodynamics

There is limited information regarding Albendazole Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Albendazole Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Albendazole Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Albendazole Clinical Studies in the drug label.

How Supplied

There is limited information regarding Albendazole How Supplied in the drug label.

Storage

There is limited information regarding Albendazole Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Albendazole |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Albendazole |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Albendazole Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Albendazole interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Albendazole Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Albendazole Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

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