Mycobacterium abscessus medical therapy: Difference between revisions

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* Parenteral antibiotics: [[amikacin]] ''OR'' [[cefoxitin]] ''OR'' [[imipenem]]
* Parenteral antibiotics: [[amikacin]] ''OR'' [[cefoxitin]] ''OR'' [[imipenem]]


===Antibiotic Dosage====
====Antibiotic Dosage====


===Pulmonary Infection===
===Pulmonary Infection===

Revision as of 19:41, 23 July 2014

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]

Overview

Treatment

Skin and Soft Tissue Infections

The treatment of mycobacterium abscessus include the following:

  • Draining collections of pus
  • Surgical debridement[1]
  • Administration of combination of antibiotics for a prolonged period of time: macrolide based regimen[1]

Antibiotic Regimen

In case of serious skin, soft tissues, and bones infection, a combination of antibiotics need to be administered:

PLUS

Antibiotic Dosage

Pulmonary Infection

  • Administration of combination of antibiotics for a prolonged period of time: clarithromycin 1,000 mg/day based regimen[1]
    • A combination of antibiotics is indicated for the treatment of pulmonary infection with mycobacterium abscessus; however, there is no evidence on the optimal multidrug regimen.
  • Surgical resection of the localized disease[1]
    • Surgical resection and multidrug antibiotic therapy is associated with a higher chance of a successful treatment.

References

  1. 1.0 1.1 1.2 1.3 Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F; et al. (2007). "An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases". Am J Respir Crit Care Med. 175 (4): 367–416. doi:10.1164/rccm.200604-571ST. PMID 17277290.


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