Transcription elongation regulator 1: Difference between revisions

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Revision as of 05:23, 16 October 2017

Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.^[1]^[2]^[3]

Function

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.^[1]

Interactions

Transcription elongation regulator 1 has been shown to interact with SF1^[4] and POLR2A.^[5]

References

↑ ^1.0 ^1.1 "Entrez Gene: TCERG1 transcription elongation regulator 1".
↑ Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Molecular and Cellular Biology. 17 (10): 6029–39. PMC 232452. PMID 9315662.
↑ Bohne J, Cole SE, Suñe C, Lindman BR, Ko VD, Vogt TF, Garcia-Blanco MA (October 2000). "Expression analysis and mapping of the mouse and human transcriptional regulator CA150". Mammalian Genome. 11 (10): 930–3. doi:10.1007/s003350010162. PMID 11003711.
↑ Goldstrohm, A C; Albrecht T R; Suñé C; Bedford M T; Garcia-Blanco M A (November 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. United States. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. ISSN 0270-7306. PMC 99933. PMID 11604498.
↑ Carty, S M; Goldstrohm A C; Suñé C; Garcia-Blanco M A; Greenleaf A L (August 2000). "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (16): 9015–20. doi:10.1073/pnas.160266597. ISSN 0027-8424. PMC 16813. PMID 10908677.

Suñé C, Hayashi T, Liu Y, et al. (1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. 17 (10): 6029–39. PMC 232452. PMID 9315662.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
Suñé C, Garcia-Blanco MA (1999). "Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner". Mol. Cell. Biol. 19 (7): 4719–28. PMC 84270. PMID 10373521.
Carty SM, Goldstrohm AC, Suñé C, et al. (2000). "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9015–20. doi:10.1073/pnas.160266597. PMC 16813. PMID 10908677.
Bohne J, Cole SE, Suñe C, et al. (2000). "Expression analysis and mapping of the mouse and human transcriptional regulator CA150". Mamm. Genome. 11 (10): 930–3. doi:10.1007/s003350010162. PMID 11003711.
Holbert S, Denghien I, Kiechle T, et al. (2001). "The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1811–6. doi:10.1073/pnas.041566798. PMC 29339. PMID 11172033.
Goldstrohm AC, Albrecht TR, Suñé C, et al. (2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. PMC 99933. PMID 11604498.
Zhou Z, Licklider LJ, Gygi SP, Reed R (2002). "Comprehensive proteomic analysis of the human spliceosome". Nature. 419 (6903): 182–5. doi:10.1038/nature01031. PMID 12226669.
Carty SM, Greenleaf AL (2003). "Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing". Mol. Cell. Proteomics. 1 (8): 598–610. doi:10.1074/mcp.M200029-MCP200. PMID 12376575.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chattopadhyay B, Ghosh S, Gangopadhyay PK, et al. (2003). "Modulation of age at onset in Huntington's disease and spinocerebellar ataxia type 2 patients originated from eastern India". Neurosci. Lett. 345 (2): 93–6. doi:10.1016/S0304-3940(03)00436-1. PMID 12821179.
Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
Palancade B, Marshall NF, Tremeau-Bravard A, et al. (2004). "Dephosphorylation of RNA polymerase II by CTD-phosphatase FCP1 is inhibited by phospho-CTD associating proteins". J. Mol. Biol. 335 (2): 415–24. doi:10.1016/j.jmb.2003.10.036. PMID 14672652.
Nagel JE, Smith RJ, Shaw L, et al. (2005). "Identification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10". BMC Immunol. 5: 17. doi:10.1186/1471-2172-5-17. PMC 514893. PMID 15296517.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC 517884. PMID 15456888.
Smith MJ, Kulkarni S, Pawson T (2004). "FF domains of CA150 bind transcription and splicing factors through multiple weak interactions". Mol. Cell. Biol. 24 (21): 9274–85. doi:10.1128/MCB.24.21.9274-9285.2004. PMC 522232. PMID 15485897.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
McFie PJ, Wang GL, Timchenko NA, et al. (2006). "Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha". J. Biol. Chem. 281 (26): 18069–80. doi:10.1074/jbc.M512734200. PMID 16644732.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[entrez-1] 1.0 ^1.1 "Entrez Gene: TCERG1 transcription elongation regulator 1".

[pmid9315662-2] Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Molecular and Cellular Biology. 17 (10): 6029–39. PMC 232452. PMID 9315662.

[pmid11003711-3] Bohne J, Cole SE, Suñe C, Lindman BR, Ko VD, Vogt TF, Garcia-Blanco MA (October 2000). "Expression analysis and mapping of the mouse and human transcriptional regulator CA150". Mammalian Genome. 11 (10): 930–3. doi:10.1007/s003350010162. PMID 11003711.

[pmid11604498-4] Goldstrohm, A C; Albrecht T R; Suñé C; Bedford M T; Garcia-Blanco M A (November 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. United States. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. ISSN 0270-7306. PMC 99933. PMID 11604498.

[pmid10908677-5] Carty, S M; Goldstrohm A C; Suñé C; Garcia-Blanco M A; Greenleaf A L (August 2000). "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (16): 9015–20. doi:10.1073/pnas.160266597. ISSN 0027-8424. PMC 16813. PMID 10908677.

[1]

[2]

[3]

[4]

[5]

@@ Line 1: / Line 1: @@
+{{Infobox_gene}}
+'''Transcription elongation regulator 1''', also known as '''TCERG1''', is a [[protein]] which in humans is encoded by the ''TCERG1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TCERG1 transcription elongation regulator 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10915| accessdate = }}</ref><ref name="pmid9315662">{{cite journal |vauthors=Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA | title = CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription | journal = Molecular and Cellular Biology | volume = 17 | issue = 10 | pages = 6029–39 |date=October 1997 | pmid = 9315662 | pmc = 232452 | doi = | url = http://mcb.asm.org/cgi/content/abstract/17/10/6029 | issn = }}</ref><ref name="pmid11003711">{{cite journal |vauthors=Bohne J, Cole SE, Suñe C, Lindman BR, Ko VD, Vogt TF, Garcia-Blanco MA | title = Expression analysis and mapping of the mouse and human transcriptional regulator CA150 | journal = Mammalian Genome | volume = 11 | issue = 10 | pages = 930–3 |date=October 2000 | pmid = 11003711 | doi = 10.1007/s003350010162 | url = | issn = }}</ref>
+== Function ==
+This gene encodes a nuclear protein that regulates [[Transcription (genetics)#Elongation|transcriptional elongation]] and pre-[[mRNA splicing]]. The encoded protein interacts with the hyperphosphorylated [[C-terminus|C-terminal]] [[protein domain|domain]] of [[RNA polymerase II]] via multiple FF domains, and with the pre-mRNA splicing factor [[SF1 (gene)|SF1]] via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.<ref name="entrez" />
+==Interactions==
+Transcription elongation regulator 1 has been shown to [[Protein-protein interaction|interact]] with [[SF1 (gene)|SF1]]<ref name=pmid11604498>{{cite journal |last=Goldstrohm |first=A C |authorlink= |author2=Albrecht T R |author3=Suñé C |author4=Bedford M T |author5=Garcia-Blanco M A  |date=November 2001 |title=The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1 |journal=Mol. Cell. Biol. |volume=21 |issue=22 |pages=7617–28 |publisher= |location = United States| issn = 0270-7306| pmid = 11604498 |doi = 10.1128/MCB.21.22.7617-7628.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=99933 }}</ref> and [[POLR2A]].<ref name=pmid10908677>{{cite journal |last=Carty |first=S M |authorlink= |author2=Goldstrohm A C |author3=Suñé C |author4=Garcia-Blanco M A |author5=Greenleaf A L  |date=August 2000 |title=Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=16 |pages=9015–20 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10908677 |doi = 10.1073/pnas.160266597 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=16813 }}</ref>
+== References ==
+{{Reflist}}
+== Further reading ==
+{{Refbegin | 2}}
+{{PBB_Further_reading
+| citations =
+*{{cite journal   |vauthors=Suñé C, Hayashi T, Liu Y, etal |title=CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription |journal=Mol. Cell. Biol. |volume=17 |issue= 10 |pages= 6029–39 |year= 1997 |pmid= 9315662 |doi=  | pmc=232452  }}
+*{{cite journal   |vauthors=Neubauer G, King A, Rappsilber J, etal |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700 }}
+*{{cite journal  |vauthors=Suñé C, Garcia-Blanco MA |title=Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4719–28 |year= 1999 |pmid= 10373521 |doi=  | pmc=84270  }}
+*{{cite journal   |vauthors=Carty SM, Goldstrohm AC, Suñé C, etal |title=Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 9015–20 |year= 2000 |pmid= 10908677 |doi= 10.1073/pnas.160266597  | pmc=16813 }}
+*{{cite journal   |vauthors=Bohne J, Cole SE, Suñe C, etal |title=Expression analysis and mapping of the mouse and human transcriptional regulator CA150 |journal=Mamm. Genome |volume=11 |issue= 10 |pages= 930–3 |year= 2000 |pmid= 11003711 |doi=10.1007/s003350010162  }}
+*{{cite journal   |vauthors=Holbert S, Denghien I, Kiechle T, etal |title=The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 4 |pages= 1811–6 |year= 2001 |pmid= 11172033 |doi= 10.1073/pnas.041566798  | pmc=29339 }}
+*{{cite journal   |vauthors=Goldstrohm AC, Albrecht TR, Suñé C, etal |title=The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1 |journal=Mol. Cell. Biol. |volume=21 |issue= 22 |pages= 7617–28 |year= 2001 |pmid= 11604498 |doi= 10.1128/MCB.21.22.7617-7628.2001  | pmc=99933 }}
+*{{cite journal  |vauthors=Zhou Z, Licklider LJ, Gygi SP, Reed R |title=Comprehensive proteomic analysis of the human spliceosome |journal=Nature |volume=419 |issue= 6903 |pages= 182–5 |year= 2002 |pmid= 12226669 |doi= 10.1038/nature01031 }}
+*{{cite journal  |vauthors=Carty SM, Greenleaf AL |title=Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing |journal=Mol. Cell. Proteomics |volume=1 |issue= 8 |pages= 598–610 |year= 2003 |pmid= 12376575 |doi=  10.1074/mcp.M200029-MCP200}}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
+*{{cite journal   |vauthors=Chattopadhyay B, Ghosh S, Gangopadhyay PK, etal |title=Modulation of age at onset in Huntington's disease and spinocerebellar ataxia type 2 patients originated from eastern India |journal=Neurosci. Lett. |volume=345 |issue= 2 |pages= 93–6 |year= 2003 |pmid= 12821179 |doi=10.1016/S0304-3940(03)00436-1  }}
+*{{cite journal   |vauthors=Reuter TY, Medhurst AL, Waisfisz Q, etal |title=Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport |journal=Exp. Cell Res. |volume=289 |issue= 2 |pages= 211–21 |year= 2003 |pmid= 14499622 |doi=10.1016/S0014-4827(03)00261-1  }}
+*{{cite journal   |vauthors=Palancade B, Marshall NF, Tremeau-Bravard A, etal |title=Dephosphorylation of RNA polymerase II by CTD-phosphatase FCP1 is inhibited by phospho-CTD associating proteins |journal=J. Mol. Biol. |volume=335 |issue= 2 |pages= 415–24 |year= 2004 |pmid= 14672652 |doi=10.1016/j.jmb.2003.10.036  }}
+*{{cite journal   |vauthors=Nagel JE, Smith RJ, Shaw L, etal |title=Identification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10 |journal=BMC Immunol. |volume=5|pages= 17 |year= 2005 |pmid= 15296517 |doi= 10.1186/1471-2172-5-17  | pmc=514893 }}
+*{{cite journal   |vauthors=Goehler H, Lalowski M, Stelzl U, etal |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }}
+*{{cite journal  |vauthors=Lin KT, Lu RM, Tarn WY |title=The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9176–85 |year= 2004 |pmid= 15456888 |doi= 10.1128/MCB.24.20.9176-9185.2004  | pmc=517884 }}
+*{{cite journal  |vauthors=Smith MJ, Kulkarni S, Pawson T |title=FF domains of CA150 bind transcription and splicing factors through multiple weak interactions |journal=Mol. Cell. Biol. |volume=24 |issue= 21 |pages= 9274–85 |year= 2004 |pmid= 15485897 |doi= 10.1128/MCB.24.21.9274-9285.2004  | pmc=522232 }}
+*{{cite journal   |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
+*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 }}
+*{{cite journal   |vauthors=McFie PJ, Wang GL, Timchenko NA, etal |title=Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha |journal=J. Biol. Chem. |volume=281 |issue= 26 |pages= 18069–80 |year= 2006 |pmid= 16644732 |doi= 10.1074/jbc.M512734200 }}
+}}
+{{Refend}}
+{{PDB Gallery|geneid=10915}}
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+| update_summary = no
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_TCERG1_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e0l.
- | PDB = {{PDB2|1e0l}}, {{PDB2|2dk7}}, {{PDB2|2dod}}, {{PDB2|2doe}}, {{PDB2|2dof}}, {{PDB2|2nnt}}
- | Name = Transcription elongation regulator 1
- | HGNCid = 15630
- | Symbol = TCERG1
- | AltSymbols =; CA150; MGC133200; TAF2S
- | OMIM = 605409
- | ECnumber =
- | Homologene = 4879
- | MGIid = 1926421
- | GeneAtlas_image1 = PBB_GE_TCERG1_202396_at_tn.png
- | Function = {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 10915
-    | Hs_Ensembl = ENSG00000113649
-    | Hs_RefseqProtein = NP_001035095
-    | Hs_RefseqmRNA = NM_001040006
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 5
-    | Hs_GenLoc_start = 145807087
-    | Hs_GenLoc_end = 145871263
-    | Hs_Uniprot = O14776
-    | Mm_EntrezGene = 56070
-    | Mm_Ensembl = ENSMUSG00000024498
-    | Mm_RefseqmRNA = NM_001039474
-    | Mm_RefseqProtein = NP_001034563
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 18
-    | Mm_GenLoc_start = 42637460
-    | Mm_GenLoc_end = 42701758
-    | Mm_Uniprot = Q3TH57
-  }}
-}}
-'''Transcription elongation regulator 1''', also known as '''TCERG1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TCERG1 transcription elongation regulator 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10915| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: TCERG1 transcription elongation regulator 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10915| accessdate = }}</ref>
-}}
-==References==
-{{reflist|2}}
-==Further reading==
-{{refbegin | 2}}
-{{PBB_Further_reading
-| citations =
-*{{cite journal  | author=Suñé C, Hayashi T, Liu Y, ''et al.'' |title=CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription. |journal=Mol. Cell. Biol. |volume=17 |issue= 10 |pages= 6029-39 |year= 1997 |pmid= 9315662 |doi=  }}
-*{{cite journal  | author=Neubauer G, King A, Rappsilber J, ''et al.'' |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46-50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700 }}
-*{{cite journal  | author=Suñé C, Garcia-Blanco MA |title=Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4719-28 |year= 1999 |pmid= 10373521 |doi=  }}
-*{{cite journal  | author=Carty SM, Goldstrohm AC, Suñé C, ''et al.'' |title=Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 9015-20 |year= 2000 |pmid= 10908677 |doi= 10.1073/pnas.160266597 }}
-*{{cite journal  | author=Bohne J, Cole SE, Suñe C, ''et al.'' |title=Expression analysis and mapping of the mouse and human transcriptional regulator CA150. |journal=Mamm. Genome |volume=11 |issue= 10 |pages= 930-3 |year= 2000 |pmid= 11003711 |doi=  }}
-*{{cite journal  | author=Holbert S, Denghien I, Kiechle T, ''et al.'' |title=The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 4 |pages= 1811-6 |year= 2001 |pmid= 11172033 |doi= 10.1073/pnas.041566798 }}
-*{{cite journal  | author=Goldstrohm AC, Albrecht TR, Suñé C, ''et al.'' |title=The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. |journal=Mol. Cell. Biol. |volume=21 |issue= 22 |pages= 7617-28 |year= 2001 |pmid= 11604498 |doi= 10.1128/MCB.21.22.7617-7628.2001 }}
-*{{cite journal  | author=Zhou Z, Licklider LJ, Gygi SP, Reed R |title=Comprehensive proteomic analysis of the human spliceosome. |journal=Nature |volume=419 |issue= 6903 |pages= 182-5 |year= 2002 |pmid= 12226669 |doi= 10.1038/nature01031 }}
-*{{cite journal  | author=Carty SM, Greenleaf AL |title=Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing. |journal=Mol. Cell Proteomics |volume=1 |issue= 8 |pages= 598-610 |year= 2003 |pmid= 12376575 |doi=  }}
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Transcription elongation regulator 1: Difference between revisions

Revision as of 05:23, 16 October 2017

Contents

Function

Interactions

References

Further reading

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