SMTN: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Underlinked|date=June 2016}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Smoothelin''' is a [[protein]] that in humans is encoded by the ''SMTN'' [[gene]].<ref name="pmid9244445">{{cite journal | vauthors = Engelen JJ, Esterling LE, Albrechts JC, Detera-Wadleigh SD, van Eys GJ | title = Assignment of the human gene for smoothelin (SMTN) to chromosome 22q12 by fluorescence in situ hybridization and radiation hybrid mapping | journal = Genomics | volume = 43 | issue = 2 | pages = 245–7 |date=Sep 1997 | pmid = 9244445 | pmc =  | doi = 10.1006/geno.1997.9999 }}</ref><ref name="pmid8707825">{{cite journal | vauthors = van der Loop FT, Schaart G, Timmer ED, Ramaekers FC, van Eys GJ | title = Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells | journal = J Cell Biol | volume = 134 | issue = 2 | pages = 401–11 |date=Sep 1996 | pmid = 8707825 | pmc = 2120883 | doi =10.1083/jcb.134.2.401 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SMTN smoothelin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6525| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SMTN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2d87.
| PDB = {{PDB2|2d87}}
| Name = Smoothelin
| HGNCid = 11126
| Symbol = SMTN
| AltSymbols =; FLJ35365; FLJ38597
| OMIM = 602127
| ECnumber =
| Homologene = 8482
| MGIid = 1354727
  | GeneAtlas_image1 = PBB_GE_SMTN_207390_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SMTN_209427_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0008307 |text = structural constituent of muscle}}
| Component = {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006939 |text = smooth muscle contraction}} {{GNF_GO|id=GO:0007517 |text = muscle development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6525
    | Hs_Ensembl = ENSG00000183963
    | Hs_RefseqProtein = NP_008863
    | Hs_RefseqmRNA = NM_006932
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 29807305
    | Hs_GenLoc_end = 29830609
    | Hs_Uniprot = P53814
    | Mm_EntrezGene = 29856
    | Mm_Ensembl = ENSMUSG00000020439
    | Mm_RefseqmRNA = NM_013870
    | Mm_RefseqProtein = NP_038898
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 3417526
    | Mm_GenLoc_end = 3439295
    | Mm_Uniprot = 
  }}
}}
'''Smoothelin''', also known as '''SMTN''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SMTN smoothelin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6525| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in three transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: SMTN smoothelin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6525| accessdate = }}</ref>
| summary_text = This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in three transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: SMTN smoothelin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6525| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Luft FC |title=Differentiating one smooth operator from another. |journal=J. Mol. Med. |volume=77 |issue= 2 |pages= 255-7 |year= 1999 |pmid= 10023778 |doi=  }}
*{{cite journal  | author=Luft FC |title=Differentiating one smooth operator from another. |journal=J. Mol. Med. |volume=77 |issue= 2 |pages= 255–7 |year= 1999 |pmid= 10023778 |doi=10.1007/s001090050347 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=van der Loop FT, Schaart G, Timmer ED, ''et al.'' |title=Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells. |journal=J. Cell Biol. |volume=134 |issue= 2 |pages= 401-11 |year= 1996 |pmid= 8707825 |doi= }}
*{{cite journal   |vauthors=van Eys GJ, Völler MC, Timmer ED, etal |title=Smoothelin expression characteristics: development of a smooth muscle cell in vitro system and identification of a vascular variant. |journal=Cell Struct. Funct. |volume=22 |issue= 1 |pages= 65–72 |year= 1997 |pmid= 9113392 |doi=10.1247/csf.22.65  }}
*{{cite journal | author=van Eys GJ, Völler MC, Timmer ED, ''et al.'' |title=Smoothelin expression characteristics: development of a smooth muscle cell in vitro system and identification of a vascular variant. |journal=Cell Struct. Funct. |volume=22 |issue= 1 |pages= 65-72 |year= 1997 |pmid= 9113392 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Engelen JJ, Esterling LE, Albrechts JC, ''et al.'' |title=Assignment of the human gene for smoothelin (SMTN) to chromosome 22q12 by fluorescence in situ hybridization and radiation hybrid mapping. |journal=Genomics |volume=43 |issue= 2 |pages= 245-7 |year= 1997 |pmid= 9244445 |doi= 10.1006/geno.1997.9999 }}
*{{cite journal  |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=  10.1101/gr.8.11.1097}}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Krämer J, Aguirre-Arteta AM, Thiel C, etal |title=A novel isoform of the smooth muscle cell differentiation marker smoothelin. |journal=J. Mol. Med. |volume=77 |issue= 2 |pages= 294–8 |year= 1999 |pmid= 10023782 |doi=10.1007/s001090050352 }}
*{{cite journal  | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
*{{cite journal  | vauthors=Johansson B, Eriksson A, Ramaekers F, Thornell L |title=Smoothelin in adult and developing human arteries and myocardium. |journal=Histochem. Cell Biol. |volume=112 |issue= 4 |pages= 291–9 |year= 2000 |pmid= 10550614 |doi=10.1007/s004180050450 }}
*{{cite journal | author=Krämer J, Aguirre-Arteta AM, Thiel C, ''et al.'' |title=A novel isoform of the smooth muscle cell differentiation marker smoothelin. |journal=J. Mol. Med. |volume=77 |issue= 2 |pages= 294-8 |year= 1999 |pmid= 10023782 |doi=  }}
*{{cite journal   |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal  | author=Johansson B, Eriksson A, Ramaekers F, Thornell L |title=Smoothelin in adult and developing human arteries and myocardium. |journal=Histochem. Cell Biol. |volume=112 |issue= 4 |pages= 291-9 |year= 2000 |pmid= 10550614 |doi=  }}
*{{cite journal   |vauthors=Gsell S, Eschenhagen T, Kaspareit G, etal |title=Apparent up-regulation of stimulatory G-protein alpha subunits in the pregnant human myometrium is mimicked by elevated smoothelin expression. |journal=FASEB J. |volume=14 |issue= 1 |pages= 17–26 |year= 2000 |pmid= 10627276 |doi=  }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal   |vauthors=Krämer J, Quensel C, Meding J, etal |title=Identification and characterization of novel smoothelin isoforms in vascular smooth muscle. |journal=J. Vasc. Res. |volume=38 |issue= 2 |pages= 120–32 |year= 2001 |pmid= 11316948 |doi=10.1159/000051039 }}
*{{cite journal | author=Gsell S, Eschenhagen T, Kaspareit G, ''et al.'' |title=Apparent up-regulation of stimulatory G-protein alpha subunits in the pregnant human myometrium is mimicked by elevated smoothelin expression. |journal=FASEB J. |volume=14 |issue= 1 |pages= 17-26 |year= 2000 |pmid= 10627276 |doi=  }}
*{{cite journal   |vauthors=Rensen SS, Thijssen VL, De Vries CJ, etal |title=Expression of the smoothelin gene is mediated by alternative promoters. |journal=Cardiovasc. Res. |volume=55 |issue= 4 |pages= 850–63 |year= 2002 |pmid= 12176134 |doi=10.1016/S0008-6363(02)00491-1 }}
*{{cite journal | author=Krämer J, Quensel C, Meding J, ''et al.'' |title=Identification and characterization of novel smoothelin isoforms in vascular smooth muscle. |journal=J. Vasc. Res. |volume=38 |issue= 2 |pages= 120-32 |year= 2001 |pmid= 11316948 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Rensen SS, Thijssen VL, De Vries CJ, ''et al.'' |title=Expression of the smoothelin gene is mediated by alternative promoters. |journal=Cardiovasc. Res. |volume=55 |issue= 4 |pages= 850-63 |year= 2002 |pmid= 12176134 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=6525}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


{{gene-22-stub}}
{{gene-22-stub}}
{{WikiDoc Sources}}

Revision as of 06:42, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Smoothelin is a protein that in humans is encoded by the SMTN gene.[1][2][3]

This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in three transcript variants.[3]

References

  1. ↑ Engelen JJ, Esterling LE, Albrechts JC, Detera-Wadleigh SD, van Eys GJ (Sep 1997). "Assignment of the human gene for smoothelin (SMTN) to chromosome 22q12 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics. 43 (2): 245–7. doi:10.1006/geno.1997.9999. PMID 9244445.
  2. ↑ van der Loop FT, Schaart G, Timmer ED, Ramaekers FC, van Eys GJ (Sep 1996). "Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells". J Cell Biol. 134 (2): 401–11. doi:10.1083/jcb.134.2.401. PMC 2120883. PMID 8707825.
  3. ↑ 3.0 3.1 "Entrez Gene: SMTN smoothelin".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=SMTN&oldid=1420034"