NOL5A: Difference between revisions

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{{Infobox_gene}}
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'''Nucleolar protein 56''' is a [[protein]] that in humans is encoded by the ''NOP56'' [[gene]].<ref name="pmid9372940">{{cite journal |vauthors=Gautier T, Berges T, Tollervey D, Hurt E | title = Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis | journal = Mol Cell Biol | volume = 17 | issue = 12 | pages = 7088–98 |date=Dec 1997 | pmid = 9372940 | pmc = 232565 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NOL5A nucleolar protein 5A (56kDa with KKE/D repeat)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10528| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Nucleolar protein 5A (56kDa with KKE/D repeat)
| HGNCid = 15911
| Symbol = NOL5A
| AltSymbols =; NOP56
| OMIM =
| ECnumber =
| Homologene = 4660
| MGIid = 1914384
| GeneAtlas_image1 = PBB_GE_NOL5A_200875_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NOL5A_200874_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}}  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process = {{GNF_GO|id=GO:0006364 |text = rRNA processing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10528
    | Hs_Ensembl = ENSG00000101361
    | Hs_RefseqProtein = NP_006383
    | Hs_RefseqmRNA = NM_006392
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 2580791
    | Hs_GenLoc_end = 2587039
    | Hs_Uniprot = O00567
    | Mm_EntrezGene = 67134
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_024193
    | Mm_RefseqProtein = NP_077155
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Nucleolar protein 5A (56kDa with KKE/D repeat)''', also known as '''NOL5A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NOL5A nucleolar protein 5A (56kDa with KKE/D repeat)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10528| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them have not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: NOL5A nucleolar protein 5A (56kDa with KKE/D repeat)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10528| accessdate = }}</ref>
| summary_text = Nop56p is a yeast nucleolar protein that is part of a complex with the [[nucleolar]] proteins Nop58p and [[fibrillarin]]. Nop56p is required for assembly of the [[Eukaryotic large ribosomal subunit (60S)|60S ribosomal subunit]] and is involved in [[Preribosomal_RNA#Ribosomal_RNA_processing|pre-rRNA processing]]. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them have not been determined.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Gautier T, Bergès T, Tollervey D, Hurt E |title=Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis. |journal=Mol. Cell. Biol. |volume=17 |issue= 12 |pages= 7088-98 |year= 1997 |pmid= 9372940 |doi=  }}
*{{cite journal  | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |name-list-format=vanc| author2=Matthews LH | author3=Ashurst J | display-authors=3  | last4=Burton  | first4=J. | last5=Gilbert  | first5=J. G. R. | last6=Jones  | first6=M.  | last7=Stavrides  | first7=G.  | last8=Almeida  | first8=J. P.  | last9=Babbage  | first9=A. K. }}
*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | author=Andersen JS |title=Directed proteomic analysis of the human nucleolus |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9  |name-list-format=vanc| author2=Lyon CE  | author3=Fox AH  | display-authors=3  | last4=Leung  | first4=Anthony K.L.  | last5=Lam  | first5=Yun Wah  | last6=Steen  | first6=Hanno  | last7=Mann  | first7=Matthias  | last8=Lamond  | first8=Angus I. }}
*{{cite journal  | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
*{{cite journal  |vauthors=Watkins NJ, Dickmanns A, Lührmann R |title=Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP |journal=Mol. Cell. Biol. |volume=22 |issue= 23 |pages= 8342–52 |year= 2003 |pmid= 12417735 |doi=10.1128/MCB.22.23.8342-8352.2002  | pmc=134055 }}
*{{cite journal  | author=Watkins NJ, Dickmanns A, Lührmann R |title=Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP. |journal=Mol. Cell. Biol. |volume=22 |issue= 23 |pages= 8342-52 |year= 2003 |pmid= 12417735 |doi=  }}
*{{cite journal  | author=Scherl A |title=Functional proteomic analysis of human nucleolus |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100–9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 | pmc=133617  |name-list-format=vanc| author2=Couté Y  | author3=Déon C  | display-authors=3  | last4=Callé  | first4=A  | last5=Kindbeiter  | first5=K  | last6=Sanchez  | first6=JC  | last7=Greco  | first7=A  | last8=Hochstrasser  | first8=D  | last9=Diaz  | first9=JJ }}
*{{cite journal  | author=Scherl A, Couté Y, Déon C, ''et al.'' |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100-9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Hayano T |title=Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34309–19 |year= 2003 |pmid= 12777385 |doi= 10.1074/jbc.M304304200 |name-list-format=vanc| author2=Yanagida M  | author3=Yamauchi Y  | display-authors=3  | last4=Shinkawa  | first4=T  | last5=Isobe  | first5=T  | last6=Takahashi  | first6=N }}
*{{cite journal  | author=Hayano T, Yanagida M, Yamauchi Y, ''et al.'' |title=Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34309-19 |year= 2003 |pmid= 12777385 |doi= 10.1074/jbc.M304304200 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Hassel S |title=Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry |journal=Proteomics |volume=4 |issue= 5 |pages= 1346–58 |year= 2004 |pmid= 15188402 |doi= 10.1002/pmic.200300770 |name-list-format=vanc| author2=Eichner A  | author3=Yakymovych M  | display-authors=3  | last4=Hellman  | first4=Ulf  | last5=Knaus  | first5=Petra  | last6=Souchelnytskyi  | first6=Serhiy }}
*{{cite journal  | author=Hassel S, Eichner A, Yakymovych M, ''et al.'' |title=Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. |journal=Proteomics |volume=4 |issue= 5 |pages= 1346-58 |year= 2004 |pmid= 15188402 |doi= 10.1002/pmic.200300770 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Watkins NJ |title=Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex |journal=Mol. Cell |volume=16 |issue= 5 |pages= 789–98 |year= 2005 |pmid= 15574333 |doi= 10.1016/j.molcel.2004.11.012 |name-list-format=vanc| author2=Lemm I  | author3=Ingelfinger D  | display-authors=3  | last4=Schneider  | first4=Claudia  | last5=Hoßbach  | first5=Markus  | last6=Urlaub  | first6=Henning  | last7=Lührmann  | first7=Reinhard }}
*{{cite journal  | author=Watkins NJ, Lemm I, Ingelfinger D, ''et al.'' |title=Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex. |journal=Mol. Cell |volume=16 |issue= 5 |pages= 789-98 |year= 2005 |pmid= 15574333 |doi= 10.1016/j.molcel.2004.11.012 }}
*{{cite journal  | author=Andersen JS |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |name-list-format=vanc| author2=Lam YW  | author3=Leung AK  | display-authors=3  | last4=Ong  | first4=Shao-En  | last5=Lyon  | first5=Carol E.  | last6=Lamond  | first6=Angus I.  | last7=Mann  | first7=Matthias }}
*{{cite journal  | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal  | author=Nousiainen M |title=Phosphoproteome analysis of the human mitotic spindle |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365  |name-list-format=vanc| author2=Silljé HH  | author3=Sauer G  | display-authors=3  | last4=Nigg  | first4=EA  | last5=Körner  | first5=R }}
*{{cite journal  | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal  | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |name-list-format=vanc| author2=Blagoev B  | author3=Gnad F  | display-authors=3  | last4=Macek  | first4=Boris  | last5=Kumar  | first5=Chanchal  | last6=Mortensen  | first6=Peter  | last7=Mann  | first7=Matthias }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
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Revision as of 13:09, 5 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nucleolar protein 56 is a protein that in humans is encoded by the NOP56 gene.[1][2]

Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them have not been determined.[2]

References

  1. ↑ Gautier T, Berges T, Tollervey D, Hurt E (Dec 1997). "Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis". Mol Cell Biol. 17 (12): 7088–98. PMC 232565. PMID 9372940.
  2. ↑ 2.0 2.1 "Entrez Gene: NOL5A nucleolar protein 5A (56kDa with KKE/D repeat)".

Further reading



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