Endodermal sinus tumor: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
No edit summary
Line 1: Line 1:
'''Editor-in-Chief:''' Somal Khan, M.D.
'''For patient information, click [[Endodermal sinus tumor (patient information)|here]]'''
 
{{Editor Help}}


{{Infobox_Disease |
{{Infobox_Disease |
Line 17: Line 15:
   MeshID        = D018240 |
   MeshID        = D018240 |
}}
}}
{{Search infobox}}
{{Endodermal sinus tumor}}
'''Editor-in-Chief:''' [[C. Michael Gibson, M.S., M.D.]] [mailto:mgibson@perfuse.org] Phone:617-632-7753; {{AOEIC}} Somal Khan, M.D.
 
==[[Endodermal sinus tumor overview|Overview]]==
 
==[[Endodermal sinus tumor classification|Classification]]==
 
==[[Endodermal sinus tumor historical perspective|Historical Perspective]]==
 
==[[Endodermal sinus tumor pathophysiology|Pathophysiology]]==
 
==[[Endodermal sinus tumor epidemiology and demographics|Epidemiology & Demographics]]==
 
==[[Endodermal sinus tumor epidemiology and demographics|Risk Factors]]==
 
==[[Endodermal sinus tumor screening|Screening]]==
 
==[[Endodermal sinus tumor causes|Causes]]==


==Overview==
==[[Endodermal sinus tumor differential diagnosis|Differentiating Endodermal sinus tumor from other Diseases]]==
'''Endodermal sinus tumor''' ('''EST'''), also known as '''yolk sac tumor''' ('''YST'''), is a member of the [[germ cell tumor]] group of [[cancer]]s.  Endodermal sinus tumor frequently develops within other kinds of germ cell tumor, particularly within [[teratoma]].  While pure teratoma is usually [[benign]], endodermal sinus tumor is [[malignant]].


{{main|Germ cell tumor}}
==[[Endodermal sinus tumor natural history|Natural History, Complications & Prognosis]]==
{{main|Teratoma}}


==Diagnosis==
==Diagnosis==
The [[histology]] of EST is variable, but usually includes malignant endodermal cells.  These cells express [[alpha-fetoprotein]] (AFP), which can be detected in tumor tissue or [[blood plasma|serum]].  When there is incongruence between [[biopsy]] and AFP test results for EST, the result indicating presence of EST should guide treatment.<ref name="pmid16598424">{{cite journal
[[Endodermal sinus tumor history and symptoms|History & Symptoms]] | [[Endodermal sinus tumor physical examination|Physical Examination]] | [[Endodermal sinus tumor staging|Staging]] | [[Endodermal sinus tumor laboratory tests|Lab Tests]] | [[Endodermal sinus tumor electrocardiogram|Electrocardiogram]] | [[Endodermal sinus tumor chest x ray|Chest X Ray]] | [[Endodermal sinus tumor CT|CT]] | [[Endodermal sinus tumor MRI|MRI]] | [[Endodermal sinus tumor echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Endodermal sinus tumor other imaging findings|Other Imaging Findings]] | [[Endodermal sinus tumor other diagnostic studies#Microscopic Pathology|Microscopic Pathology]]
| author = Luther N, Edgar MA, Dunkel IJ, Souweidane MM
| title = Correlation of endoscopic biopsy with tumor marker status in primary intracranial germ cell tumors.
| journal = J. Neurooncol.
| volume = 79
| issue = 1
| pages = 45-50
| year = 2006
| pmid = 16598424
| doi = 10.1007/s11060-005-9110-0
| issn =
}}</ref>  This is because EST often occurs as small "malignant foci" within a larger tumor, usually [[teratoma]];  biopsy of the tumor may reveal only teratoma, whereas elevated AFP in [[serum]] or [[cerebrospinal fluid]] reveals that EST is also present.  GATA-4, a [[transcription factor]], also may be useful in the diagnosis of EST.<ref name="pmid10595911">{{cite journal
| author = Siltanen S, Anttonen M, Heikkilä P, Narita N, Laitinen M, Ritvos O, Wilson DB, Heikinheimo M
| title = Transcription factor GATA-4 is expressed in pediatric yolk sac tumors.
| journal = Am. J. Pathol.
| volume = 155
| issue = 6
| pages = 1823-9
| year = 1999
| pmid = 10595911
| doi =
| issn =
}} (free full text on PubMed Central)</ref>
 
{{main|Alpha-fetoprotein}}


==Treatment==
==Treatment==
Most treatments involve some combination of [[surgery]] and [[chemotherapy]].
[[Endodermal sinus tumor medical therapy|Medical Therapy]] | [[Endodermal sinus tumor surgery|Surgery]] | [[Endodermal sinus tumor primary prevention|Primary Prevention]] | [[Endodermal sinus tumor secondary prevention|Secondary Prevention]]  


Before modern chemotherapy, this type of neoplasm was highly lethal, but the prognosis has significantly improved since.
==Related chapters==
 
{{main|Germ cell tumor}}
==References==
{{main|Teratoma}}
{{reflist}}
{{main|Alpha-fetoprotein}}


==External links==
==Resources==
* {{GPnotebook|-1543110606}}
* {{GPnotebook|-1543110606}}


{{SIB}}
{{Tumors}}
{{Tumors}}
{{Soft tissue tumors and sarcomas}}
{{Soft tissue tumors and sarcomas}}

Revision as of 18:21, 20 January 2012

For patient information, click here

Endodermal sinus tumor
ICD-O: 9071/3
DiseasesDB 4248
MeSH D018240

Template:Endodermal sinus tumor Editor-in-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753; Associate Editor(s)-In-Chief: Somal Khan, M.D.

Overview

Classification

Historical Perspective

Pathophysiology

Epidemiology & Demographics

Risk Factors

Screening

Causes

Differentiating Endodermal sinus tumor from other Diseases

Natural History, Complications & Prognosis

Diagnosis

History & Symptoms | Physical Examination | Staging | Lab Tests | Electrocardiogram | Chest X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Microscopic Pathology

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention

Related chapters

Main article: Germ cell tumor
Main article: Teratoma
Main article: Alpha-fetoprotein

Resources

Template:Tumors


Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Endodermal_sinus_tumor&oldid=623162"