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***Small VSD
***Small VSD
**Mid to late systolic murmurs
**Mid to late systolic murmurs
{{familytree | | |,|-|-|-|-|+|-|-|-|-|.| | | | | | | | | | | | | | | | | | | | |}}
{{familytree | | C01 | | | C02 | | | C03 | | | | | | | | | | | | | | | | | | | | |C01=<div style="float: left; text-align: left; width: 28em; padding:1em;">Maximum intensity over apex Radiation to axilla or base A2 not heard over apex Decreased intensity with amyl nitrate|C02=<div style="float: left; text-align: left; width: 28em; padding:1em;">Maximum intensity over left sternal border Radiation to epigastrium and right sternal border Increased intensity during inspiration Prominent c-v wave with sharp y descent in jugular venous pulse|C03=<div style="float: left; text-align: left; width: 28em; padding:1em;">Maximum intensity over lower left third and fourth interspace Widespread radiation, palpable thrill Decreased intensity with amyl nitrate No change in intensity during inspiration Wide splitting of S2}}
{{familytree | | |!| | | | |!| | | | |!| | | | | | | | | | | | | | | | | | | | | }}
{{familytree | | C01 | | | C02 | | | C03 | | | | | | | | | | | | | | | | | | | |C01=Mitral regurgitation|C02=Tricuspid regurgitation|C03=Favors ventricular septal defect; often difficult to differentiate from
mitral regurgitant murmur}}
{{familytree | |,|^|-|-|.| |!| | | | | | | | | | | | | | | | | | | | | | | | | | }}
{{familytree | C01 | | C02 |)|-| C03 |-| C04 | | | | | | | | | | | | | | | | | |C01=Hyperdynamic left ventricular impulse<br> Wide splitting of S2|C02=Sustained left ventricular impulse<br> Single S2 or narrow splitting of S2|C03=Prominent left parasternal diastolic impulse<BR> Normal brief left parasternal systolic impulse<br> Normal P2, Rarely paradoxical S2|C04=Primary }}
{{familytree | |!| | | |!| |!| | | | | | | | | | | | | | | | | | | | | | | | | | }}
{{familytree | |!| | | |!| |`|-| C01 |-| C02 | | | | | | | | | | | | | | | | | | |C01=Sustained systolic left parasternal impulse Narrow splitting of S2 with marked increase in intensity of P2|C02=Secondary to pulmonary hypertension}}
{{familytree | C01 | | C02 | | | | | | | | | | | | | | | | | | | | | | | | | | |C01=Primary mitral regurgitation|C02=Secondary mitral regurgitation}}


<br />
=='''Table 1. Risk Score For Drug-Associated QTc Prolongation'''==
{| class="wikitable" style="border: 0px; font-size: 90%; margin: 3px;" align="center"
! rowspan="1" style="background: #4479BA; padding: 5px 5px;" |'''Risk Factors'''
! colspan="1" style="background: #4479BA; padding: 5px 5px;" |'''Points'''
|-
| style="padding: 5px 5px; background: #F5F5F5;" |Age ≥68 y




| style="padding: 5px 5px; background: #F5F5F5;" |1




<br />
{| class="wikitable" border="1"
!style="width: 300px;background:#4479BA"|{{fontcolor|#FFF| SYSTOLIC MURMUR}} !!style="width: 300px;background:#4479BA"|{{fontcolor|#FFF|  DIASTOLIC MURMUR}} !! style="width: 300px;background:#4479BA"|{{fontcolor|#FFF| Continuous Murmur}}
|-
|-
|Female sex
| ❑ '''[[MR resident survival guide#Treatment|STEMI / LBBB]]''' <br> ❑ '''[[NSTEMI resident survival guide#Treatment|NSTEMI / Unstable angina]]''' <br> ❑ '''[[Chronic stable angina treatment|Stable angina]]'''<br> ❑ '''[[Pericarditis resident survival guide#Treatment|Pericarditis]]'''<br> ❑ '''[[Aortic dissection resident survival guide#Treatment|Aortic dissection]]'''<br> ❑ '''[[Aortic stenosis resident survival guide#Treatment|Aortic stenosis]]'''  <br>❑ '''[[Prinzmetal's angina#Medical Therapy|Prinzmetal's angina]]''' <br> ❑  '''[[PCI complications: coronary vasospasm#Treatment|PCI-induced coronary vasospasm]]''' <br> ❑ '''[[New guidelines for the management of cocaine chest pain|Cocaine induced coronary vasospasm]]'''
|1
| ❑ '''[[Pulmonary embolism resident survival guide#Treatment|Pulmonary embolism]]'''<br> ❑ '''[[Tension pneumothorax resident survival guide#Treatment|Pneumothorax]]'''<br>❑ '''[[Asthma exacerbation resident survival guide|Asthma exacerbation ]]'''<br> ❑ '''[[Pulmonary hypertension resident survival guide#Treatment|Pulmonary hypertension]]'''<br> ❑ '''[[Pneumonia medical therapy |Pneumonia ]]''' <br> ❑ '''[[Pleurisy medical therapy |Pleuritis]]'''
|-
| ❑ '''[[Pancreatitis medical therapy |Pancreatitis ]]''' <br> ❑ '''[[Acute cholecystitis resident survival guide#Treatment Approach|Acute cholecystitis]]''' <br> ❑ '''[[Gastroesophageal reflux disease medical therapy|GERD]]''' <br>❑ '''[[Peptic ulcer medical therapy|Peptic ulcer]]''' <br>❑ '''[[Nutcracker esophagus medical therapy|Esophageal spasm]]'''<br>❑ '''[[Mallory-Weiss syndrome medical therapy|Mallory-Weiss syndrome]]''' <br>
|Loop diuretic
| ❑ Musculoskeletal pain:
|1
: ❑ [[Costochondritis]]<br> ❑ [[Rheumatoid arthritis medical therapy|Rheumatoid arthritis]]  <br> ❑ [[Rib fracture#Treatment|Rib fracture]]
|-
❑ '''[[Herpes zoster medical therapy|Herpes zoster]]''' <br> ❑ '''[[Anxiety medical therapy|Anxiety]]''' <br> ❑ '''[[Panic disorder#Treatment|Panic disorder]]'''
|Serum K+ ≤3.5 mEq/L
|2
|-
|Admission QTc ≥450 ms
|2
|-
|Acute MI
|2
|-
|≥2 QTc-prolonging drugs
|3
|-
|sepsis
|3
|-
|Heart failure
|3
|-
|One QTc-prolonging drug
|3
|-
|Maximum Risk Score
|21
|-
|K+ indicates potassium; and MI, myocardial infarction.
|
|}__NOTOC__
A Tisdale score of ≤ 6 predicts low risk, 7-10 medium risk, and ≥ 11 high risk of drug-associated QT prolongation (Table 2).
{| class="wikitable"
!'''Table 2. Risk Levels For Drug-Associated QT Prolongation'''
|-
|Low risk = ≤6 points
|-
|Moderate risk = 7-10 points
|-
|High-risk = ≥11 points
|}
|}
<br />

Revision as of 04:06, 16 August 2020



    • Holosystolic (pansystolic) murmurs:
      • chronic MR.
      • chronic TR.
      • VSD
      • PDA with pulmonary hypertension
    • Midsystolic (systolic ejection) murmurs
      • Innocent murmur (still's murmur)
      • AS
      • PS
      • HOCM
      • Functional:
        • ASD
        • VSD
        • Straight back syndrome
        • Aortic root dilation
        • Pulmonary artery dilation
        • pulmonary hypertension
        • Hyper-kinetic status:
          • pregnancy
          • Anemia
          • hyperthyroidism
          • exercise
          • A-V fistula
    • Early systolic murmurs
      • Acute MR
      • Acute TR
      • Small VSD
    • Mid to late systolic murmurs
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Maximum intensity over apex Radiation to axilla or base A2 not heard over apex Decreased intensity with amyl nitrate
 
 
Maximum intensity over left sternal border Radiation to epigastrium and right sternal border Increased intensity during inspiration Prominent c-v wave with sharp y descent in jugular venous pulse
 
 
Maximum intensity over lower left third and fourth interspace Widespread radiation, palpable thrill Decreased intensity with amyl nitrate No change in intensity during inspiration Wide splitting of S2
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Mitral regurgitation
 
 
Tricuspid regurgitation
 
 
Favors ventricular septal defect; often difficult to differentiate from mitral regurgitant murmur
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Hyperdynamic left ventricular impulse
Wide splitting of S2
 
Sustained left ventricular impulse
Single S2 or narrow splitting of S2
 
 
 
Prominent left parasternal diastolic impulse
Normal brief left parasternal systolic impulse
Normal P2, Rarely paradoxical S2
 
Primary
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Sustained systolic left parasternal impulse Narrow splitting of S2 with marked increase in intensity of P2
 
Secondary to pulmonary hypertension
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Primary mitral regurgitation
 
Secondary mitral regurgitation
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 





SYSTOLIC MURMUR DIASTOLIC MURMUR Continuous Murmur
STEMI / LBBB
NSTEMI / Unstable angina
Stable angina
Pericarditis
Aortic dissection
Aortic stenosis
Prinzmetal's angina
PCI-induced coronary vasospasm
Cocaine induced coronary vasospasm
Pulmonary embolism
Pneumothorax
Asthma exacerbation
Pulmonary hypertension
Pneumonia
Pleuritis
Pancreatitis
Acute cholecystitis
GERD
Peptic ulcer
Esophageal spasm
Mallory-Weiss syndrome
❑ Musculoskeletal pain:
Costochondritis
Rheumatoid arthritis
Rib fracture

Herpes zoster
Anxiety
Panic disorder