Paget-Schroetter disease laboratory findings: Difference between revisions
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* [[Paget-Schroetter disease]] is not diagnosed based on laboratory findings since except [[D-dimer]], other laboratory values are commonly normal. | * [[Paget-Schroetter disease]] is not diagnosed based on laboratory findings since except [[D-dimer]], other laboratory values are commonly normal. | ||
* To exclude other [[differential diagnosis]] consider laboratory workups from the list below: | * To exclude other [[differential diagnosis]] consider laboratory workups from the list below: | ||
** [[Complete blood count|CBC]] | **[[Complete blood count|CBC]] | ||
** [[Thrombophilia]] panel ([[protein C]] and [[Protein S|S]] levels, [[Antithrombin|antithrombin levels]], [[Prothrombin gene mutation G20210A|prothrombin gene mutation]] analysis, [[factor V Leiden mutation]] testing)<ref name="pmid29494023">{{cite journal| author=| title=StatPearls | journal= | year= 2020 | volume= | issue= | pages= | pmid=29494023 | doi= | pmc= | url= }}</ref> | ** [[Thrombophilia]] panel ([[protein C]] and [[Protein S|S]] levels, [[Antithrombin|antithrombin levels]], [[Prothrombin gene mutation G20210A|prothrombin gene mutation]] analysis, [[factor V Leiden mutation]] testing)<ref name="pmid29494023">{{cite journal| author=| title=StatPearls | journal= | year= 2020 | volume= | issue= | pages= | pmid=29494023 | doi= | pmc= | url= }}</ref> | ||
** [[Liver function tests]] | ** [[Liver function tests]] | ||
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== Laboratory Findings == | == Laboratory Findings == | ||
* Elevated [[D-dimer]]<ref name="IbrahimDashkova2017">{{cite journal|last1=Ibrahim|first1=Ramy|last2=Dashkova|first2=Irina|last3=Williams|first3=Myia|last4=Kozikowski|first4=Andrzej|last5=Abrol|first5=Neeraj|last6=Gandhi|first6=Anjula|last7=Pekmezaris|first7=Renee|title=Paget-Schroetter syndrome in the absence of common predisposing factors: a case report|journal=Thrombosis Journal|volume=15|issue=1|year=2017|issn=1477-9560|doi=10.1186/s12959-017-0146-0}}</ref> | * Elevated [[D-dimer]]<ref name="IbrahimDashkova2017">{{cite journal|last1=Ibrahim|first1=Ramy|last2=Dashkova|first2=Irina|last3=Williams|first3=Myia|last4=Kozikowski|first4=Andrzej|last5=Abrol|first5=Neeraj|last6=Gandhi|first6=Anjula|last7=Pekmezaris|first7=Renee|title=Paget-Schroetter syndrome in the absence of common predisposing factors: a case report|journal=Thrombosis Journal|volume=15|issue=1|year=2017|issn=1477-9560|doi=10.1186/s12959-017-0146-0}}</ref> | ||
** Elevated D-dimer level has only 14-60% [[Specificity (tests)|specificity]] in [[Upper limb|upper extremity]] vein [[thrombosis]].<ref name="HanggeRotellini-Coltvet2017">{{cite journal|last1=Hangge|first1=Patrick|last2=Rotellini-Coltvet|first2=Lisa |last3=Deipolyi|first3=Amy R. |last4=Albadawi|first4=Hassan |last5=Oklu|first5=Rahmi |title=Paget-Schroetter syndrome: treatment of venous thrombosis and outcomes|journal=Cardiovascular Diagnosis and Therapy|volume=7|issue=S3|year=2017|pages=S285–S290|issn=22233652|doi=10.21037/cdt.2017.08.15}}</ref> | |||
** Since the [[Paget-Schroetter disease]] is rare, there is no established data supporting routine [[D-dimer|D-dimer test]] or a definitive diagnostic tool.<ref name="HanggeRotellini-Coltvet20172">{{cite journal|last1=Hangge|first1=Patrick|last2=Rotellini-Coltvet|first2=Lisa |last3=Deipolyi|first3=Amy R. |last4=Albadawi|first4=Hassan |last5=Oklu|first5=Rahmi |title=Paget-Schroetter syndrome: treatment of venous thrombosis and outcomes|journal=Cardiovascular Diagnosis and Therapy|volume=7|issue=S3|year=2017|pages=S285–S290|issn=22233652|doi=10.21037/cdt.2017.08.15}}</ref> | |||
==References== | ==References== | ||
Revision as of 17:12, 3 June 2020
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Overview
- Paget-Schroetter disease is not diagnosed based on laboratory findings since except D-dimer, other laboratory values are commonly normal.
- To exclude other differential diagnosis consider laboratory workups from the list below:
Laboratory Findings
- Elevated D-dimer[6]
- Elevated D-dimer level has only 14-60% specificity in upper extremity vein thrombosis.[7]
- Since the Paget-Schroetter disease is rare, there is no established data supporting routine D-dimer test or a definitive diagnostic tool.[8]
References
- ↑ "StatPearls". 2020. PMID 29494023.
- ↑ Spencer TR, Lagace RE, Waterman G (2014). "Effort thrombosis (Paget-Schroetter syndrome) in a 16-year-old male". Am J Case Rep. 15: 333–6. doi:10.12659/AJCR.890726. PMC 4138064. PMID 25098327.
- ↑ Spencer TR, Lagace RE, Waterman G (2014). "Effort thrombosis (Paget-Schroetter syndrome) in a 16-year-old male". Am J Case Rep. 15: 333–6. doi:10.12659/AJCR.890726. PMC 4138064. PMID 25098327.
- ↑ Spencer TR, Lagace RE, Waterman G (2014). "Effort thrombosis (Paget-Schroetter syndrome) in a 16-year-old male". Am J Case Rep. 15: 333–6. doi:10.12659/AJCR.890726. PMC 4138064. PMID 25098327.
- ↑ Spencer TR, Lagace RE, Waterman G (2014). "Effort thrombosis (Paget-Schroetter syndrome) in a 16-year-old male". Am J Case Rep. 15: 333–6. doi:10.12659/AJCR.890726. PMC 4138064. PMID 25098327.
- ↑ Ibrahim, Ramy; Dashkova, Irina; Williams, Myia; Kozikowski, Andrzej; Abrol, Neeraj; Gandhi, Anjula; Pekmezaris, Renee (2017). "Paget-Schroetter syndrome in the absence of common predisposing factors: a case report". Thrombosis Journal. 15 (1). doi:10.1186/s12959-017-0146-0. ISSN 1477-9560.
- ↑ Hangge, Patrick; Rotellini-Coltvet, Lisa; Deipolyi, Amy R.; Albadawi, Hassan; Oklu, Rahmi (2017). "Paget-Schroetter syndrome: treatment of venous thrombosis and outcomes". Cardiovascular Diagnosis and Therapy. 7 (S3): S285–S290. doi:10.21037/cdt.2017.08.15. ISSN 2223-3652.
- ↑ Hangge, Patrick; Rotellini-Coltvet, Lisa; Deipolyi, Amy R.; Albadawi, Hassan; Oklu, Rahmi (2017). "Paget-Schroetter syndrome: treatment of venous thrombosis and outcomes". Cardiovascular Diagnosis and Therapy. 7 (S3): S285–S290. doi:10.21037/cdt.2017.08.15. ISSN 2223-3652.