Sandbox:Hannan: Difference between revisions
Jump to navigation
Jump to search
Hannan Javed (talk | contribs) No edit summary |
Hannan Javed (talk | contribs) No edit summary |
||
Line 61: | Line 61: | ||
|<small>Bone marrow aspirate and unilateral biopsy with conventional cytogenetics and flow cytometry</small> | |<small>Bone marrow aspirate and unilateral biopsy with conventional cytogenetics and flow cytometry</small> | ||
| | | | ||
* <small>FISH for t(9;22)(q34;q11.2)</small> | |||
* <small>Reverse transcriptase quantitative PCR (RQ-PCR) for BCR-ABL</small> | |||
| | | | ||
|- | |- |
Revision as of 19:04, 15 January 2019
Myeloproliferative neoplasms (MPN) | Clinical manifestations | Diagnosis | Other features | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Symptoms | Physical examination | Lab findings | Bone marrow biopsy | Gold standard | Other investigations | ||||||||||
WBCs | RBCs | Platelets | |||||||||||||
Leukocytosis | Blasts | Left shift | Basophilia | Eosinophilia | Monocytosis | Others | |||||||||
Chronic myeloid leukemia
(CML), BCR-ABL1+ |
|
|
Absolute leukocytosis (median of 100,000/µL) | Blasts usually <2% | Left shift with classic myelocyte bulge (myelocytes > metamyelocytes on the blood smear)
|
Absolute basophilia is almost always present | Absolute eosinophilia in 90% of patients | Often present | Anemia | Platelet count is usually normal or elevated but thrombocytopenia indicates advanced stage or an alternative diagnosis | Bone marrow aspirate and unilateral biopsy with conventional cytogenetics and flow cytometry |
|
|||
Chronic neutrophilic leukemia (CNL) | |||||||||||||||
Polycythemia vera (PV) | |||||||||||||||
Primary myelofibrosis (PMF)
|
|||||||||||||||
Essential thrombocythemia (ET) | |||||||||||||||
Chronic eosinophilic leukemia, not otherwise specified (NOS) | |||||||||||||||
MPN, unclassifiable | |||||||||||||||
Mastocytosis |
Other myeloid neoplasm and acute leukemia | Clinical manifestations | Diagnosis | Other features | ||||
---|---|---|---|---|---|---|---|
Symptoms | Physical examination | Lab findings | Bone marrow biopsy | Gold standard | Other investigations | ||
Myeloid/lymphoid neoplasms with eosinophilia and rearrangement of
PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2
|
|||||||
Myelodysplastic/myeloproliferative neoplasms (MDS/MPN)
|
|||||||
Myelodysplastic syndromes (MDS)
|
|||||||
Acute myeloid leukemia (AML) and related neoplasms
|
|||||||
Blastic plasmacytoid dendritic cell neoplasm | |||||||
Acute leukemias of ambiguous lineage
|
|||||||
B-lymphoblastic leukemia/lymphoma
|
|||||||
T-lymphoblastic leukemia/lymphoma
|
- 50% of patients are asymptomatic
- Clinical features are generally nonspecific such as left upper quadrant pain, early satiety, fatigue & lethargy (most common presenting symptom), weight loss, and night sweats.
- symptoms of anemia
- bleeding
- priapism
- bone pain
- Abdominal mass or fullness
- Infection
- Headache
- Dyspnoea
- Visual disturbances
- Weakness
- Arthralgia
- Cough
- Malaise
- Dizziness
- Nausea/vomiting
- Ankle oedema
- Mental change