AP1S2: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
imported>Jmertel23
m (added wikilinks and removed "underlinked" tag)
 
Line 1: Line 1:
{{Underlinked|date=February 2015}}
 
{{Infobox_gene}}
{{Infobox_gene}}
'''AP-1 complex subunit sigma-2''' is a [[protein]] that in humans is encoded by the ''AP1S2'' [[gene]].<ref name="pmid9733768">{{cite journal | vauthors = Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K | title = Identification and characterization of novel clathrin adaptor-related proteins | journal = The Journal of Biological Chemistry | volume = 273 | issue = 38 | pages = 24693–700 | date = Sep 1998 | pmid = 9733768 | pmc =  | doi = 10.1074/jbc.273.38.24693 }}</ref><ref name="pmid17186471">{{cite journal | vauthors = Tarpey PS, Stevens C, Teague J, Edkins S, O'Meara S, Avis T, Barthorpe S, Buck G, Butler A, Cole J, Dicks E, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, West S, Widaa S, Yates A, Catford R, Butler J, Mallya U, Moon J, Luo Y, Dorkins H, Thompson D, Easton DF, Wooster R, Bobrow M, Carpenter N, Simensen RJ, Schwartz CE, Stevenson RE, Turner G, Partington M, Gecz J, Stratton MR, Futreal PA, Raymond FL | title = Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation | journal = American Journal of Human Genetics | volume = 79 | issue = 6 | pages = 1119–24 | date = Dec 2006 | pmid = 17186471 | pmc = 1698718 | doi = 10.1086/510137 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AP1S2 adaptor-related protein complex 1, sigma 2 subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8905| accessdate = }}</ref>
'''AP-1 complex subunit sigma-2''' is a [[protein]] that in humans is encoded by the ''AP1S2'' [[gene]].<ref name="pmid9733768">{{cite journal | vauthors = Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K | title = Identification and characterization of novel clathrin adaptor-related proteins | journal = The Journal of Biological Chemistry | volume = 273 | issue = 38 | pages = 24693–700 | date = Sep 1998 | pmid = 9733768 | pmc =  | doi = 10.1074/jbc.273.38.24693 }}</ref><ref name="pmid17186471">{{cite journal | vauthors = Tarpey PS, Stevens C, Teague J, Edkins S, O'Meara S, Avis T, Barthorpe S, Buck G, Butler A, Cole J, Dicks E, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, West S, Widaa S, Yates A, Catford R, Butler J, Mallya U, Moon J, Luo Y, Dorkins H, Thompson D, Easton DF, Wooster R, Bobrow M, Carpenter N, Simensen RJ, Schwartz CE, Stevenson RE, Turner G, Partington M, Gecz J, Stratton MR, Futreal PA, Raymond FL | title = Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation | journal = American Journal of Human Genetics | volume = 79 | issue = 6 | pages = 1119–24 | date = Dec 2006 | pmid = 17186471 | pmc = 1698718 | doi = 10.1086/510137 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AP1S2 adaptor-related protein complex 1, sigma 2 subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8905| accessdate = }}</ref>
Line 5: Line 5:
== Function ==
== Function ==


Adaptor protein complex 1 is found at the [[cytoplasmic]] face of coated [[vesicle (biology and chemistry)|vesicles]] located at the [[Golgi complex]], where it mediates both the recruitment of [[clathrin]] to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small [[adaptin]] subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants utilizing alternative [[polyadenylation]] signals exist for this gene.<ref name="entrez"/>
Adaptor protein complex 1 is found at the [[cytoplasmic]] face of coated [[vesicle (biology and chemistry)|vesicles]] located at the [[Golgi complex]], where it mediates both the recruitment of [[clathrin]] to the [[Cell membrane|membrane]] and the recognition of sorting signals within the cytosolic tails of [[transmembrane receptors]]. This complex is a [[heterotetramer]] composed of two large, one medium, and one small [[adaptin]] subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. [[Transcript variants]] utilizing alternative [[polyadenylation]] signals exist for this gene.<ref name="entrez"/>


== References ==
== References ==

Latest revision as of 17:43, 16 February 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

AP-1 complex subunit sigma-2 is a protein that in humans is encoded by the AP1S2 gene.[1][2][3]

Function

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants utilizing alternative polyadenylation signals exist for this gene.[3]

References

  1. ↑ Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K (Sep 1998). "Identification and characterization of novel clathrin adaptor-related proteins". The Journal of Biological Chemistry. 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. PMID 9733768.
  2. ↑ Tarpey PS, Stevens C, Teague J, Edkins S, O'Meara S, Avis T, Barthorpe S, Buck G, Butler A, Cole J, Dicks E, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, West S, Widaa S, Yates A, Catford R, Butler J, Mallya U, Moon J, Luo Y, Dorkins H, Thompson D, Easton DF, Wooster R, Bobrow M, Carpenter N, Simensen RJ, Schwartz CE, Stevenson RE, Turner G, Partington M, Gecz J, Stratton MR, Futreal PA, Raymond FL (Dec 2006). "Mutations in the gene encoding the Sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation". American Journal of Human Genetics. 79 (6): 1119–24. doi:10.1086/510137. PMC 1698718. PMID 17186471.
  3. ↑ 3.0 3.1 "Entrez Gene: AP1S2 adaptor-related protein complex 1, sigma 2 subunit".

External links

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=AP1S2&oldid=1534242"