DPY19L2: Difference between revisions

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{{Underlinked|date=April 2014}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Dpy-19-like 2 (C. elegans)''' is a [[protein]] that in humans is encoded by the DPY19L2 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: Dpy-19-like 2 (C. elegans) | url = https://www.ncbi.nlm.nih.gov/gene/283417 }}</ref>


'''Dpy-19-like 2 (C. elegans)''' is a [[protein]] that in humans is encoded by the DPY19L2 [[gene]].
== Function ==
<ref name="entrez">
{{cite web
| title = Entrez Gene: Dpy-19-like 2 (C. elegans)
| url = https://www.ncbi.nlm.nih.gov/gene/283417
| accessdate = 2014-03-29 <!-- T01:31:52.458381-08:00 -->
}}</ref>


==Function==
The protein encoded by this gene belongs to the dpy-19 (developmental pluripotancy-associated) family. It is highly expressed in [[testis]], and is required for sperm head elongation and [[acrosome]] formation during [[spermatogenesis]]. Mutations in this gene are associated with an [[male infertility|infertility]] disorder, spermatogenic failure type 9 (SPGF9).
 
The protein encoded by this gene belongs to the dpy-19 family. It is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility disorder, spermatogenic failure type 9 (SPGF9).


== References ==
== References ==
{{reflist}}
{{reflist}}


== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
*{{Cite journal
* {{cite journal | vauthors = Harbuz R, Zouari R, Pierre V, Ben Khelifa M, Kharouf M, Coutton C, Merdassi G, Abada F, Escoffier J, Nikas Y, Vialard F, Koscinski I, Triki C, Sermondade N, Schweitzer T, Zhioua A, Zhioua F, Latrous H, Halouani L, Ouafi M, Makni M, Jouk PS, Sèle B, Hennebicq S, Satre V, Viville S, Arnoult C, Lunardi J, Ray PF | title = A recurrent deletion of DPY19L2 causes infertility in man by blocking sperm head elongation and acrosome formation | journal = American Journal of Human Genetics | volume = 88 | issue = 3 | pages = 351–61 | date = March 2011 | pmid = 21397064 | pmc = 3059422 | doi = 10.1016/j.ajhg.2011.02.007 }}
| pmid = 21397064
* {{cite journal | vauthors = Coutton C, Zouari R, Abada F, Ben Khelifa M, Merdassi G, Triki C, Escalier D, Hesters L, Mitchell V, Levy R, Sermondade N, Boitrelle F, Vialard F, Satre V, Hennebicq S, Jouk PS, Arnoult C, Lunardi J, Ray PF | title = MLPA and sequence analysis of DPY19L2 reveals point mutations causing globozoospermia | journal = Human Reproduction | volume = 27 | issue = 8 | pages = 2549–58 | date = August 2012 | pmid = 22627659 | doi = 10.1093/humrep/des160 }}
| year = 2011
* {{cite journal | vauthors = Elinati E, Kuentz P, Redin C, Jaber S, Vanden Meerschaut F, Makarian J, Koscinski I, Nasr-Esfahani MH, Demirol A, Gurgan T, Louanjli N, Iqbal N, Bisharah M, Pigeon FC, Gourabi H, De Briel D, Brugnon F, Gitlin SA, Grillo JM, Ghaedi K, Deemeh MR, Tanhaei S, Modarres P, Heindryckx B, Benkhalifa M, Nikiforaki D, Oehninger SC, De Sutter P, Muller J, Viville S | title = Globozoospermia is mainly due to DPY19L2 deletion via non-allelic homologous recombination involving two recombination hotspots | journal = Human Molecular Genetics | volume = 21 | issue = 16 | pages = 3695–702 | date = August 2012 | pmid = 22653751 | doi = 10.1093/hmg/dds200 }}
| author1 = Harbuz
* {{cite journal | vauthors = Carson AR, Cheung J, Scherer SW | title = Duplication and relocation of the functional DPY19L2 gene within low copy repeats | journal = BMC Genomics | volume = 7 | pages = 45 | date = March 2006 | pmid = 16526957 | pmc = 1475853 | doi = 10.1186/1471-2164-7-45 }}
| first1 = R
* {{cite journal | vauthors = Coutton C, Abada F, Karaouzene T, Sanlaville D, Satre V, Lunardi J, Jouk PS, Arnoult C, Thierry-Mieg N, Ray PF | title = Fine characterisation of a recombination hotspot at the DPY19L2 locus and resolution of the paradoxical excess of duplications over deletions in the general population | journal = PLoS Genetics | volume = 9 | issue = 3 | pages = e1003363 | date = March 2013 | pmid = 23555282 | pmc = 3605140 | doi = 10.1371/journal.pgen.1003363 }}
| title = A recurrent deletion of DPY19L2 causes infertility in man by blocking sperm head elongation and acrosome formation
| journal = The American Journal of Human Genetics
| volume = 88
| issue = 3
| pages = 351–61
| last2 = Zouari
| first2 = R
| last3 = Pierre
| first3 = V
| last4 = Ben Khelifa
| first4 = M
| last5 = Kharouf
| first5 = M
| last6 = Coutton
| first6 = C
| last7 = Merdassi
| first7 = G
| last8 = Abada
| first8 = F
| last9 = Escoffier
| first9 = J
| last10 = Nikas
| first10 = Y
| last11 = Vialard
| first11 = F
| last12 = Koscinski
| first12 = I
| last13 = Triki
| first13 = C
| last14 = Sermondade
| first14 = N
| last15 = Schweitzer
| first15 = T
| last16 = Zhioua
| first16 = A
| last17 = Zhioua
| first17 = F
| last18 = Latrous
| first18 = H
| last19 = Halouani
| first19 = L
| last20 = Ouafi
| first20 = M
| last21 = Makni
| first21 = M
| last22 = Jouk
| first22 = P. S.
| last23 = Sèle
| first23 = B
| last24 = Hennebicq
| first24 = S
| last25 = Satre
| first25 = V
| last26 = Viville
| first26 = S
| last27 = Arnoult
| first27 = C
| last28 = Lunardi
| first28 = J
| last29 = Ray
| first29 = P. F.
| doi = 10.1016/j.ajhg.2011.02.007
| pmc = 3059422
}}
*{{Cite journal
| pmid = 22627659
| year = 2012
| author1 = Coutton
| first1 = C
| title = MLPA and sequence analysis of DPY19L2 reveals point mutations causing globozoospermia
| journal = Human Reproduction
| volume = 27
| issue = 8
| pages = 2549–58
| last2 = Zouari
| first2 = R
| last3 = Abada
| first3 = F
| last4 = Ben Khelifa
| first4 = M
| last5 = Merdassi
| first5 = G
| last6 = Triki
| first6 = C
| last7 = Escalier
| first7 = D
| last8 = Hesters
| first8 = L
| last9 = Mitchell
| first9 = V
| last10 = Levy
| first10 = R
| last11 = Sermondade
| first11 = N
| last12 = Boitrelle
| first12 = F
| last13 = Vialard
| first13 = F
| last14 = Satre
| first14 = V
| last15 = Hennebicq
| first15 = S
| last16 = Jouk
| first16 = P. S.
| last17 = Arnoult
| first17 = C
| last18 = Lunardi
| first18 = J
| last19 = Ray
| first19 = P. F.
| doi = 10.1093/humrep/des160
}}
*{{Cite journal
| pmid = 22653751
| year = 2012
| author1 = Elinati
| first1 = E
| title = Globozoospermia is mainly due to DPY19L2 deletion via non-allelic homologous recombination involving two recombination hotspots
| journal = Human Molecular Genetics
| volume = 21
| issue = 16
| pages = 3695–702
| last2 = Kuentz
| first2 = P
| last3 = Redin
| first3 = C
| last4 = Jaber
| first4 = S
| last5 = Vanden Meerschaut
| first5 = F
| last6 = Makarian
| first6 = J
| last7 = Koscinski
| first7 = I
| last8 = Nasr-Esfahani
| first8 = M. H.
| last9 = Demirol
| first9 = A
| last10 = Gurgan
| first10 = T
| last11 = Louanjli
| first11 = N
| last12 = Iqbal
| first12 = N
| last13 = Bisharah
| first13 = M
| last14 = Pigeon
| first14 = F. C.
| last15 = Gourabi
| first15 = H
| last16 = De Briel
| first16 = D
| last17 = Brugnon
| first17 = F
| last18 = Gitlin
| first18 = S. A.
| last19 = Grillo
| first19 = J. M.
| last20 = Ghaedi
| first20 = K
| last21 = Deemeh
| first21 = M. R.
| last22 = Tanhaei
| first22 = S
| last23 = Modarres
| first23 = P
| last24 = Heindryckx
| first24 = B
| last25 = Benkhalifa
| first25 = M
| last26 = Nikiforaki
| first26 = D
| last27 = Oehninger
| first27 = S. C.
| last28 = De Sutter
| first28 = P
| last29 = Muller
| first29 = J
| last30 = Viville
| first30 = S
| doi = 10.1093/hmg/dds200
}}
*{{Cite journal
| pmid = 16526957
| year = 2006
| author1 = Carson
| first1 = A. R.
| title = Duplication and relocation of the functional DPY19L2 gene within low copy repeats
| journal = BMC Genomics
| volume = 7
| pages = 45
| last2 = Cheung
| first2 = J
| last3 = Scherer
| first3 = S. W.
| doi = 10.1186/1471-2164-7-45
| pmc = 1475853
}}
*{{Cite journal
| pmid = 23555282
| year = 2013
| author1 = Coutton
| first1 = C
| title = Fine characterisation of a recombination hotspot at the DPY19L2 locus and resolution of the paradoxical excess of duplications over deletions in the general population
| journal = PLoS Genetics
| volume = 9
| issue = 3
| pages = e1003363
| last2 = Abada
| first2 = F
| last3 = Karaouzene
| first3 = T
| last4 = Sanlaville
| first4 = D
| last5 = Satre
| first5 = V
| last6 = Lunardi
| first6 = J
| last7 = Jouk
| first7 = P. S.
| last8 = Arnoult
| first8 = C
| last9 = Thierry-Mieg
| first9 = N
| last10 = Ray
| first10 = P. F.
| doi = 10.1371/journal.pgen.1003363
| pmc = 3605140
}}
 
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}




Latest revision as of 05:40, 30 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Dpy-19-like 2 (C. elegans) is a protein that in humans is encoded by the DPY19L2 gene.[1]

Function

The protein encoded by this gene belongs to the dpy-19 (developmental pluripotancy-associated) family. It is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility disorder, spermatogenic failure type 9 (SPGF9).

References

  1. ↑ "Entrez Gene: Dpy-19-like 2 (C. elegans)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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