Colorectal cancer laboratory tests: Difference between revisions
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== Colorectal Cancer Laboratory Findings== | == Colorectal Cancer Laboratory Findings== | ||
*[[Complete blood count]] and differential count | Laboratory findings consistent with the diagnosis of colorectal cancer include: | ||
* | |||
* | |||
* | *[[Complete blood count]] and differential count | ||
**[[anemia]] | |||
*Low | **Individuals with [[microcytic anemia]] over 50 years of age are suspected of having colorectal cancer<ref name="ZhuKaneshiro2010">{{cite journal|last1=Zhu|first1=Amy|last2=Kaneshiro|first2=Marc|last3=Kaunitz|first3=Jonathan D.|title=Evaluation and Treatment of Iron Deficiency Anemia: A Gastroenterological Perspective|journal=Digestive Diseases and Sciences|volume=55|issue=3|year=2010|pages=548–559|issn=0163-2116|doi=10.1007/s10620-009-1108-6}}</ref> | ||
* | *[[Fecal occult blood test]]([[FOBT]]) | ||
**Demonstrates occult bleeding from the intestines | |||
*Serum [[carcino-embryogenic antigen]] ([[CEA]]) and [[CA 19-9]] <ref name="pmid10528904">{{cite journal| author=Macdonald JS| title=Carcinoembryonic antigen screening: pros and cons. | journal=Semin Oncol | year= 1999 | volume= 26 | issue= 5 | pages= 556-60 | pmid=10528904 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10528904 }}</ref> | |||
**Elevated concentrations are associated with large tumor masses and have a poor prognosis | |||
**Sensitivity of CEA in diagnosis of colorectal cancer is almost 50% | |||
*Serum iron levels | |||
**Low | |||
*Serum [[vitamin B12]] and [[folate]] levels | |||
**Low | |||
*Serum Calcium levels | |||
**Hypercalcemia seen with bone metastasis | |||
===Test for Metastasis=== | ===Test for Metastasis=== |
Revision as of 20:19, 24 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Saarah T. Alkhairy, M.D.
Overview
The laboratory findings associated with colorectal carcinoma are the following: CBC, FOBT, serum CEA and CA 19-9 concentration, serum iron concentrations, serum vitamin B12 and folate concentrations, liver function tests, and pulmonary function tests.
Colorectal Cancer Laboratory Findings
Laboratory findings consistent with the diagnosis of colorectal cancer include:
- Complete blood count and differential count
- anemia
- Individuals with microcytic anemia over 50 years of age are suspected of having colorectal cancer[1]
- Fecal occult blood test(FOBT)
- Demonstrates occult bleeding from the intestines
- Serum carcino-embryogenic antigen (CEA) and CA 19-9 [2]
- Elevated concentrations are associated with large tumor masses and have a poor prognosis
- Sensitivity of CEA in diagnosis of colorectal cancer is almost 50%
- Serum iron levels
- Low
- Serum vitamin B12 and folate levels
- Low
- Serum Calcium levels
- Hypercalcemia seen with bone metastasis
Test for Metastasis
- Abnormal liver function tests
- Abnormal pulmonary function tests
References
- ↑ Zhu, Amy; Kaneshiro, Marc; Kaunitz, Jonathan D. (2010). "Evaluation and Treatment of Iron Deficiency Anemia: A Gastroenterological Perspective". Digestive Diseases and Sciences. 55 (3): 548–559. doi:10.1007/s10620-009-1108-6. ISSN 0163-2116.
- ↑ Macdonald JS (1999). "Carcinoembryonic antigen screening: pros and cons". Semin Oncol. 26 (5): 556–60. PMID 10528904.