Thrombophilia natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
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==Complications== | ==Complications== | ||
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! Thrombophilic state | |||
! Thrombotic risk<ref name="pmid15254285">{{cite journal| author=Bates SM, Ginsberg JS| title=Clinical practice. Treatment of deep-vein thrombosis. | journal=N Engl J Med | year= 2004 | volume= 351 | issue= 3 | pages= 268-77 | pmid=15254285 | doi=10.1056/NEJMcp031676 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15254285 }} </ref> | |||
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| Trauma/General surgery | |||
| Modest | |||
|- | |||
| Age > 60 | |||
| Modest | |||
|- | |||
| Immobilization | |||
| Modest | |||
|- | |||
| Pregnancy | |||
| Modest | |||
|- | |||
| Hormone therapies | |||
| Modest | |||
|- | |||
| Factor V Leiden heterozygosity | |||
| Modest | |||
|- | |||
| Prothrombin mutation | |||
| Modest | |||
|- | |||
| Homocysteinemia | |||
| Modest | |||
|- | |||
| Increased factor VIII levels | |||
| Modest | |||
|- | |||
| Increased factor IX levels | |||
| Modest | |||
|- | |||
| Increased factor XI levels | |||
| Modest | |||
|- | |||
| Protein C and S deficiency | |||
| Intermediate | |||
|- | |||
| Dysfibrogenemia | |||
| Intermediate | |||
|- | |||
| Malignancy | |||
| High | |||
|- | |||
| APLS/Lupus anticoagulant | |||
| High | |||
|- | |||
| Myeloproliferative disorders/hyperviscosity | |||
| High | |||
|- | |||
| PNH | |||
| High | |||
|- | |||
| Orthopedic surgery | |||
| High | |||
|- | |||
| Antithrombin deficiency | |||
| High | |||
|- | |||
| Factor V Leiden homozygosity | |||
| High | |||
|- | |||
|} | |||
==Prognosis== | ==Prognosis== | ||
Revision as of 21:38, 25 June 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Asiri Ediriwickrema, M.D., M.H.S. [2]
Overview
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Natural History
Complications
| Thrombophilic state | Thrombotic risk[1] |
|---|---|
| Trauma/General surgery | Modest |
| Age > 60 | Modest |
| Immobilization | Modest |
| Pregnancy | Modest |
| Hormone therapies | Modest |
| Factor V Leiden heterozygosity | Modest |
| Prothrombin mutation | Modest |
| Homocysteinemia | Modest |
| Increased factor VIII levels | Modest |
| Increased factor IX levels | Modest |
| Increased factor XI levels | Modest |
| Protein C and S deficiency | Intermediate |
| Dysfibrogenemia | Intermediate |
| Malignancy | High |
| APLS/Lupus anticoagulant | High |
| Myeloproliferative disorders/hyperviscosity | High |
| PNH | High |
| Orthopedic surgery | High |
| Antithrombin deficiency | High |
| Factor V Leiden homozygosity | High |
Prognosis
References
- ↑ Bates SM, Ginsberg JS (2004). "Clinical practice. Treatment of deep-vein thrombosis". N Engl J Med. 351 (3): 268–77. doi:10.1056/NEJMcp031676. PMID 15254285.