Prolymphocytic leukemia: Difference between revisions

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==Classification==
==Classification==
For more details about each specific type of prolymphocytic leukemia, click on the links in blue in the algorithm below.<br>
For more details about each specific type of prolymphocytic leukemia, click on the links in blue in the algorithm below.<br>
In order to distinguish B-prolymphocytic leukemia from T-prolymphocytic leukemia, see table below.




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|B02=  ''' [[T-cell prolymphocytic leukemia]]''' }}
|B02=  ''' [[T-cell prolymphocytic leukemia]]''' }}
{{Familytree/end}}
{{Familytree/end}}


==Differentiating B-Prolymphocytic Leukemia from T-Prolymphocytic Leukemia==
==Differentiating B-Prolymphocytic Leukemia from T-Prolymphocytic Leukemia==

Revision as of 15:55, 29 April 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Carlos A Lopez, M.D. [2] Maria Fernanda Villarreal, M.D. [3]

Overview

Prolymphocytic leukemia is a rare lymphoid leukemia, which account for only about 2% of all mature lymphoid leukemias. Prolymphocytic leukemias present like leukemia and like lymphomas, they start in the lymphocytes, but do not form solid tumors. Prolymphocytic leukemias are also considered lymphoproliferative disorders, which mean that lymphocytes are produced in large amounts.

Prolymphocytic leukemia is divided into two types according the kind of cell involved: B-cell prolymphocytic leukemia and T-cell prolymphocytic leukemia. Were thought to be a rare variation of chronic lymphocytic leukemia, but are now considered a distinct disease. It is usually classified as a kind of chronic lymphocytic leukemia. Although these 2 types of prolymphocytic leukemias share some of the same characteristics, the World Health Organization (WHO) classifies them as different types of lymphoid leukemias.[1]

Classification

For more details about each specific type of prolymphocytic leukemia, click on the links in blue in the algorithm below.


 
 
 
 
 
 
Prolymphocytic leukemia
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
B-cell prolymphocytic leukemia
 
 
 
 
 
T-cell prolymphocytic leukemia
 
 

Differentiating B-Prolymphocytic Leukemia from T-Prolymphocytic Leukemia

In order to distinguish B-prolymphocytic leukemia from T-prolymphocytic leukemia, see table below.

Characteristics B-PLL T-PLL
Epidemiology
  • Rare
  • Very rare
Age
  • 60-70 years
  • 60-70 years
Onset
  • Elevated white blood cell count >100,000/microL
  • Hepatosplenomegaly
  • Elevated white blood cell count >100,000/microL
  • Splenomegaly
  • Generalized lymphadenopathy
  • Occasional skin involvement
Clinical Features

B symptoms

  • Fever
  • Swelling in the lymph nodes
  • Night sweats
  • Persistent fatigue
  • Fever
  • Persistent fatigue
  • Weight-loss
Diagnosis Peripheral blood smear
  • Prolymphocytes (90%)

Biomarkers

  • CD20+
Peripheral blood smear
  • Medium-sized lymphoid cells
  • Moderately condensed chromatin and a visible nucleolus.

Biomarkers

  • CD52+

References

  1. "World Health Organization".



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