Primary cutaneous follicle centre lymphoma medical therapy: Difference between revisions

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{{CMG}}; {{AE}} {{AS}}
{{CMG}}; {{AE}} {{AS}}
==Overvew==
==Overvew==
The predominant therapy for primary cutaneous follicle centre lymphoma is [[radiotherapy]]. Adjunctive chemotherapy may be required.
==Medical Therapy==
==Medical Therapy==
* Surgical removal and/or [[radiotherapy]] is given for localized disease.<ref name="Jaffe_2011_1"/>{{rp|314}}<ref name="Wilcox2015"/>
* Radiation using multiple radiation fields is given if the disease has wider extent with grouped lesions.<ref name="Jaffe_2011_1"/>{{rp|314}}<ref name="Armitage_2010_2"/><ref name="Sokol2012"/><ref name="Wilcox2015"/>
* For the less common situation of more extensive disease (still confined to skin), [[rituximab]] without chemotherapy is used.<ref name="Jaffe_2011_1"/>{{rp|314}}<ref name="Armitage_2010_2"/><ref name="Sokol2012"/><ref name="Wilcox2015"/>Intralesional [[interferon alpha]] (IFN-α)<ref name="Senff2008"/> and intralesional rituximab have been used.<ref name="Jaffe_2011_1"/>{{rp|314}}<ref name="Senff2008"/>
* Approximately one-third of PCFCL relapse, usually in the skin; treatment is similar to initial management<ref name="Wilcox2015"/> and overall survival remains excellent.<ref name="Suárez2013_2"/>
{|style="margin: 0 auto;"
{|style="margin: 0 auto;"
| [[File:Primary cutaneous follicle centre lympoma image 4.jpg|250px|thumb|upright|A 56-year old male patient with numerous erythematous and livid infiltrates before superficial radiotherapy.<ref name=biomedcentral>Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. BioMed Central. https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-8-147.  Accessed on March 02, 2016</ref>]]
| [[File:Primary cutaneous follicle centre lympoma image 4.jpg|250px|thumb|upright|A 56-year old male patient with numerous erythematous and livid infiltrates before superficial radiotherapy.<ref name=biomedcentral>Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. BioMed Central. https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-8-147.  Accessed on March 02, 2016</ref>]]

Revision as of 13:57, 3 March 2016

Primary cutaneous follicle centre lymphoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overvew

The predominant therapy for primary cutaneous follicle centre lymphoma is radiotherapy. Adjunctive chemotherapy may be required.

Medical Therapy

  • Surgical removal and/or radiotherapy is given for localized disease.[1]:314[2]
  • Radiation using multiple radiation fields is given if the disease has wider extent with grouped lesions.[1]:314[3][4][2]
  • For the less common situation of more extensive disease (still confined to skin), rituximab without chemotherapy is used.[1]:314[3][4][2]Intralesional interferon alpha (IFN-α)[5] and intralesional rituximab have been used.[1]:314[5]
  • Approximately one-third of PCFCL relapse, usually in the skin; treatment is similar to initial management[2] and overall survival remains excellent.[6]
A 56-year old male patient with numerous erythematous and livid infiltrates before superficial radiotherapy.[7]
A 56-year old male patient with numerous erythematous and livid infiltrates before superficial radiotherapy.[7]
Post-radiotherapy appearance.[7]
Post-radiotherapy appearance.[7]

References

  1. 1.0 1.1 1.2 1.3
  2. 2.0 2.1 2.2 2.3
  3. 3.0 3.1
  4. 4.0 4.1
  5. 5.0 5.1
  6. 7.0 7.1 7.2 7.3 Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. BioMed Central. https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-8-147. Accessed on March 02, 2016


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