Peutz-Jeghers syndrome pathophysiology: Difference between revisions

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===Microscopic Pathology===
===Microscopic Pathology===
Polyps of Peutz-Jeghers syndrome are usually non-neoplastic [[hamartomas]].<ref name="radiopaedia">Radiopaedia.http://radiopaedia.org/articles/peutz-jeghers-syndrome-2</ref> On microscopic histopathological analysis, polyps have the following characteristic findings:<ref name="librepathology">libre Pathology.http://librepathology.org/wiki/index.php/Peutz-Jeghers_syndrome</ref>
Polyps of Peutz-Jeghers syndrome are usually non-neoplastic [[hamartomas]].<ref>{{Pathology of Peutz-Jeghers syndrome. Dr Amir Rezaee and Dr Alexandra Stanislavsky et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/peutz-jeghers-syndrome-2}}</ref> On microscopic histopathological analysis, polyps have the following characteristic findings:<ref name="librepathology">libre Pathology.http://librepathology.org/wiki/index.php/Peutz-Jeghers_syndrome</ref>
*Frond-like polyp with all three components of mucosa:
*Frond-like polyp with all three components of mucosa:
:*Muscosal epithelium (melanotic mucosa, goblet cells)
:*Muscosal epithelium (melanotic mucosa, goblet cells)

Revision as of 17:12, 24 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

Peutz-Jeghers syndrome is transmitted in an autosomal dominant pattern. Polyps of Peutz-Jeghers syndrome are usually non-neoplastic hamartomas.

Pathophysiology

Genetics

Microscopic Pathology

Polyps of Peutz-Jeghers syndrome are usually non-neoplastic hamartomas.[2] On microscopic histopathological analysis, polyps have the following characteristic findings:[3]

  • Frond-like polyp with all three components of mucosa:
  • Muscosal epithelium (melanotic mucosa, goblet cells)
  • Lamina propria
  • Muscularis mucosae

References

  1. JBouquot, Jerry E.; Neville, Brad W.; Damm, Douglas D.; Allen, Carl P. (2008).Oral and Maxillofacial Pathology. Philadelphia: Saunders. p.16.11.ISBN1-4160-3435-8.
  2. Template:Pathology of Peutz-Jeghers syndrome. Dr Amir Rezaee and Dr Alexandra Stanislavsky et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/peutz-jeghers-syndrome-2
  3. libre Pathology.http://librepathology.org/wiki/index.php/Peutz-Jeghers_syndrome

Template:Digestive system neoplasia

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