Multiple endocrine neoplasia type 1 future or investigational therapies: Difference between revisions
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==Overview== | ==Overview== | ||
Future or investigational therapies of multiple endocrine neoplasia type 1 include TRK inhibitors (tropomyosin receptor kinase inhibitors), mTOR inhibitors, thienopyrimidine analogs and molecular phenotyping. | |||
==Future or Investigational Therapies== | ==Future or Investigational Therapies== | ||
* Since MEN type 1 is a rare disorder clinical trials are difficult to pursue due to paucity of study population.<ref name="pmidhttp://dx.doi.org/10.1210/jc.2012-1230">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=http://dx.doi.org/10.1210/jc.2012-1230 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref> | * Since MEN type 1 is a rare disorder clinical trials are difficult to pursue due to paucity of study population.<ref name="pmidhttp://dx.doi.org/10.1210/jc.2012-1230">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=http://dx.doi.org/10.1210/jc.2012-1230 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref> | ||
* National and international collaborations are encouraged to recruit more patients with multiple endocrine neoplasia type 1 for clinical trials. | * National and international collaborations are encouraged to recruit more patients with multiple endocrine neoplasia type 1 for clinical trials. | ||
* Use of TRK inhibitors for medullary thyroid cancer and pancreatic neuroendocrine tumors have been investigated under multicenter clinical trials. | * Use of TRK inhibitors (tropomyosin receptor kinase inhibitors) for medullary thyroid cancer and pancreatic neuroendocrine tumors have been investigated under multicenter clinical trials. | ||
* mTOR inhibitors for pancreatic neuroendocrine tumors are other trials undergoing investigation. | * mTOR inhibitors for pancreatic neuroendocrine tumors are other trials undergoing investigation. | ||
* Role of surgery for non functioning pancreatic neuroendocrine tumors are under investigation. | * Role of surgery for non functioning pancreatic neuroendocrine tumors are under investigation. |
Revision as of 15:13, 10 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Future or investigational therapies of multiple endocrine neoplasia type 1 include TRK inhibitors (tropomyosin receptor kinase inhibitors), mTOR inhibitors, thienopyrimidine analogs and molecular phenotyping.
Future or Investigational Therapies
- Since MEN type 1 is a rare disorder clinical trials are difficult to pursue due to paucity of study population.[1]
- National and international collaborations are encouraged to recruit more patients with multiple endocrine neoplasia type 1 for clinical trials.
- Use of TRK inhibitors (tropomyosin receptor kinase inhibitors) for medullary thyroid cancer and pancreatic neuroendocrine tumors have been investigated under multicenter clinical trials.
- mTOR inhibitors for pancreatic neuroendocrine tumors are other trials undergoing investigation.
- Role of surgery for non functioning pancreatic neuroendocrine tumors are under investigation.
- The interaction between menin and mixed lineage leukemia protein 1(MLL1) also known as a histone H3 lysine 4 methyltransferase has been targeted to find cure for this disorder.
- Thienopyrimidine analogs that binds to wild type menin have been investigated as a possible treatment for Multiple endocrine neoplasia type 1.
- Molecular phenotyping of tumors have been proposed to use to detect MEN type 1 tumors at an early stage.
Reference
- ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID http://dx.doi.org/10.1210/jc.2012-1230 Check
|pmid=
value (help).