Clostridium difficile infection risk factors: Difference between revisions

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*Immunosuppressive therapy needed among organ transplant recipients results in acquired immunodeficiency, which results in inadequate host immune responses that normally prevent the vegetation and growth of ''C. difficile''.
*Immunosuppressive therapy needed among organ transplant recipients results in acquired immunodeficiency, which results in inadequate host immune responses that normally prevent the vegetation and growth of ''C. difficile''.


===Risk Factors by Organ System===
==Risk Factors by Organ System==
{|style="width:80%; height:100px" border="1"
{|style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''

Revision as of 19:29, 21 April 2015

Clostridium difficile Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Common Risk Factors

Antibiotic Use

The most important risk factor is antibiotic use. Although C. difficile infection has been described with almost all antibiotics, the following antibiotics are classically and most commonly associated with development of C. difficile infection:

Hospitalization and Long-Term Care Facilities

  • The majority of C. difficile infections are hospital-acquired.
  • The risk associated with hospitalization may persist up to 12 weeks following index hospitalization.

Advanced Age

  • Elderly patients > 65 years have an approximately 8-fold increased risk of developing C. difficile infection compared with younger adults.

Environmental Contamination

  • Exposure to infected or colonized host increases the risk of C. difficile infection.

Chemotherapy

  • Chemotherapy-associated immunodeficiency results in inadequate host immune responses that normally prevent the vegetation and growth of C. difficile.

Immunodeficiency

  • Immunodeficiency results in inadequate host immune responses that normally prevent the vegetation and growth of C. difficile.

Acid Suppression

  • There are multiple reports of increased risk of C. difficile infection with gastric acid suppression.(28)
  • Nonetheless, the true association between gastric acid suppression and C. difficile infection is yet to be discovered, since '"C. difficile spores are acid-resistant, and any reduction in gastric acidity may not necessarily be associated with increased risk of infection.

Inflammatory Bowel Disease

Organ Transplantation

  • Immunosuppressive therapy needed among organ transplant recipients results in acquired immunodeficiency, which results in inadequate host immune responses that normally prevent the vegetation and growth of C. difficile.

Risk Factors by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Ampicillin, Amoxicillin, Aztreonam, Bacitracin, Carbapenem, Cefotaxime sodium, Cefprozil, Cefotetan disodium, Cefuroxime, Chloramphenicol, Clindamycin, Daptomycin, Doripenem, Lincomycin Hydrochloride, Meropenem, Metronidazole, Mupirocin, Quinupristin dalfopristin, Rifabutin, Nitrofurantoin, Oritavancin, Pantoprazole, Piperacillin, Rifampin, Streptomycin, Sulfamethoxazole, Tedizolid, Teicoplanin, Tetracycline, Tigecycline, Trimethoprim
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

References

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