RAB38: Difference between revisions

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{{Infobox_gene}}
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'''Ras-related protein Rab-38''' is a [[protein]] that in humans is encoded by the ''RAB38'' [[gene]].<ref name="pmid10910072">{{cite journal |vauthors=Jager D, Stockert E, Jager E, Gure AO, Scanlan MJ, Knuth A, Old LJ, Chen YT | title = Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library | journal = Cancer Res | volume = 60 | issue = 13 | pages = 3584–91 |date=Aug 2000 | pmid = 10910072 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RAB38 RAB38, member RAS oncogene family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23682| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = RAB38, member RAS oncogene family
| HGNCid = 9776
| Symbol = RAB38
| AltSymbols =; NY-MEL-1; rrGTPbp
| OMIM = 606281
| ECnumber = 
| Homologene = 21353
| MGIid = 1919683
| GeneAtlas_image1 = PBB_GE_RAB38_219412_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}}{{GNF_GO|id=GO:0003924 |text = GTPase activity}}{{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0016020 |text = membrane}}
  | Process = {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23682
    | Hs_Ensembl = ENSG00000123892
    | Hs_RefseqProtein = NP_071732
    | Hs_RefseqmRNA = NM_022337
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 87486096
    | Hs_GenLoc_end = 87548283
    | Hs_Uniprot = P57729
    | Mm_EntrezGene = 72433
    | Mm_Ensembl = ENSMUSG00000030559
    | Mm_RefseqmRNA = NM_028238
    | Mm_RefseqProtein = NP_082514
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 88305465
    | Mm_GenLoc_end = 88396563
    | Mm_Uniprot = Q5FW76
  }}
}}
'''RAB38, member RAS oncogene family''', also known as '''RAB38''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAB38 RAB38, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23682| accessdate = }}</ref>


In melanocytic cells RAB38 gene expression may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal | author = Hoek KS | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x |name-list-format=vanc| author2 = Schlegel NC | author3 = Eichhoff OM | display-authors = 3 | last4 = Widmer | first4 = Daniel S. | last5 = Praetorius | first5 = Christian | last6 = Einarsson | first6 = Steingrimur O. | last7 = Valgeirsdottir | first7 = Sigridur | last8 = Bergsteinsdottir | first8 = Kristin | last9 = Schepsky | first9 = Alexander }}</ref>
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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
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{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Chi A, Valencia JC, Hu ZZ, ''et al.'' |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135-44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j }}
*{{cite journal  | author=Chi A |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135–44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j |name-list-format=vanc| author2=Valencia JC  | author3=Hu ZZ  | display-authors=3  | last4=Watabe  | first4=Hidenori  | last5=Yamaguchi  | first5=Hiroshi  | last6=Mangini  | first6=Nancy J.  | last7=Huang  | first7=Hongzhan  | last8=Canfield  | first8=Victor A.  | last9=Cheng  | first9=Keith C. }}
*{{cite journal  | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal  | author=Barrios-Rodiles M |title=High-throughput mapping of a dynamic signaling network in mammalian cells |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 |name-list-format=vanc| author2=Brown KR  | author3=Ozdamar B  | display-authors=3  | last4=Bose  | first4=R  | last5=Liu  | first5=Z  | last6=Donovan  | first6=RS  | last7=Shinjo  | first7=F  | last8=Liu  | first8=Y  | last9=Dembowy  | first9=J }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Suzuki T, Miyamura Y, Inagaki K, Tomita Y |title=Characterization of the human RAB38 and RAB7 genes: exclusion of new major pathological loci for Japanese OCA. |journal=J. Dermatol. Sci. |volume=32 |issue= 2 |pages= 131-6 |year= 2004 |pmid= 12850305 |doi=  }}
*{{cite journal  |vauthors=Suzuki T, Miyamura Y, Inagaki K, Tomita Y |title=Characterization of the human RAB38 and RAB7 genes: exclusion of new major pathological loci for Japanese OCA |journal=J. Dermatol. Sci. |volume=32 |issue= 2 |pages= 131–6 |year= 2004 |pmid= 12850305 |doi=10.1016/S0923-1811(03)00071-9 }}
*{{cite journal  | author=Basrur V, Yang F, Kushimoto T, ''et al.'' |title=Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. |journal=J. Proteome Res. |volume=2 |issue= 1 |pages= 69-79 |year= 2003 |pmid= 12643545 |doi=  }}
*{{cite journal  | author=Basrur V |title=Proteomic analysis of early melanosomes: identification of novel melanosomal proteins |journal=J. Proteome Res. |volume=2 |issue= 1 |pages= 69–79 |year= 2003 |pmid= 12643545 |doi=10.1021/pr025562r  |name-list-format=vanc| author2=Yang F  | author3=Kushimoto T  | display-authors=3  | last4=Higashimoto  | first4=Youichiro  | last5=Yasumoto  | first5=Ken-Ichi  | last6=Valencia  | first6=Julio  | last7=Muller  | first7=Jacqueline  | last8=Vieira  | first8=Wilfred D.  | last9=Watabe  | first9=Hidenori }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Osanai K, Iguchi M, Takahashi K, ''et al.'' |title=Expression and localization of a novel Rab small G protein (Rab38) in the rat lung. |journal=Am. J. Pathol. |volume=158 |issue= 5 |pages= 1665-75 |year= 2001 |pmid= 11337364 |doi=  }}
*{{cite journal  | author=Osanai K |title=Expression and Localization of a Novel Rab Small G Protein (Rab38) in the Rat Lung |journal=Am. J. Pathol. |volume=158 |issue= 5 |pages= 1665–75 |year= 2001 |pmid= 11337364 |doi=  10.1016/S0002-9440(10)64122-3| pmc=1891947 |name-list-format=vanc| author2=Iguchi M  | author3=Takahashi K  | display-authors=3  | last4=Nambu  | first4=Y  | last5=Sakuma  | first5=T  | last6=Toga  | first6=H  | last7=Ohya  | first7=N  | last8=Shimizu  | first8=H  | last9=Fisher  | first9=JH }}
*{{cite journal | author=Jäger D, Stockert E, Jäger E, ''et al.'' |title=Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library. |journal=Cancer Res. |volume=60 |issue= 13 |pages= 3584-91 |year= 2000 |pmid= 10910072 |doi=  }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 08:46, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras-related protein Rab-38 is a protein that in humans is encoded by the RAB38 gene.[1][2]

In melanocytic cells RAB38 gene expression may be regulated by MITF.[3]


References

  1. ↑ Jager D, Stockert E, Jager E, Gure AO, Scanlan MJ, Knuth A, Old LJ, Chen YT (Aug 2000). "Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library". Cancer Res. 60 (13): 3584–91. PMID 10910072.
  2. ↑ "Entrez Gene: RAB38 RAB38, member RAS oncogene family".
  3. ↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading



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