Anal fissure surgery: Difference between revisions

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==Overview==
==Overview==
==Surgery==
Surgery is the option after trying the conservative and medical measures and its done in patients not responding to them, with chronic anal fissures and where fissures are complicated by fistulas and abscess. Lateral internal [[sphincterotomy]] is the procedure of choice. The complications of the surgery include fecal incontinence and therefore contraindicated in the patients having fecal incontinence. In these patients, anal advancement flap or [[Botulinum toxin]] is used.
===Chemical sphincterotomy===
Painful deep chronic fissures, on the other hand, will not heal because of poor blood supply caused by sphincter spasm. Traditionally surgical operations were required which are both painful and associated with various longterm complications, particularly incontinence in a small proportion of cases. Local application of medications to relax the sphincter muscle, thus allowing the healing to proceed, was first proposed in 1994 with [[nitroglycerine]] ointment,<!--
  --><ref>{{cite journal |author=Loder P, Kamm M, Nicholls R, Phillips R |title='Reversible chemical sphincterotomy' by local application of glyceryl trinitrate |journal=Br J Surg |volume=81 |issue=9 |pages=1386-9 |year=1994 |id=PMID 7953427}}</ref><!--
  --><ref>{{cite journal |author=Watson S, Kamm M, Nicholls R, Phillips R |title=Topical glyceryl trinitrate in the treatment of chronic anal fissure |journal=Br J Surg |volume=83 |issue=6 |pages=771-5 |year=1996 |id=PMID 8696736}}</ref><!--
  --><ref>{{cite journal | author = Simpson J, Lund J, Thompson R, Kapila L, Scholefield J | title = The use of glyceryl trinitrate (GTN) in the treatment of chronic anal fissure in children. | journal = Med Sci Monit | volume = 9 | issue = 10 | pages = PI123-6 | year = 2003 | id = PMID 14523338}}</ref>
in 1999 with [[nifedipine]] ointment,<!--
  --><ref>{{cite journal |author=Antropoli C, Perrotti P, Rubino M, Martino A, De Stefano G, Migliore G, Antropoli M, Piazza P |title=Nifedipine for local use in conservative treatment of anal fissures: preliminary results of a multicenter study |journal=Dis Colon Rectum |volume=42 |issue=8 |pages=1011-5 |year=1999 |id=PMID 10458123}}</ref><!--
  --><ref>{{cite journal |author=Katsinelos P, Kountouras J, Paroutoglou G, Beltsis A, Chatzimavroudis G, Zavos C, Katsinelos T, Papaziogas B |title=Aggressive treatment of acute anal fissure with 0.5% nifedipine ointment prevents its evolution to chronicity |journal=World J Gastroenterol |volume=12 |issue=38 |pages=6203-6 |year=2006 |id=PMID 17036396| url=http://www.wjgnet.com/1007-9327/12/6203.asp}}</ref>
and the following year with topical [[diltiazem]].<!--  --><ref>{{cite journal |author=Carapeti E, Kamm M, Phillips R |title=Topical diltiazem and bethanechol decrease anal sphincter pressure and heal anal fissures without side effects |journal=Dis. Colon Rectum |volume=43 |issue=10 |pages=1359-62 |year=2000 |pmid=11052511}}</ref>
Branded preparations are now available of topical nitroglycerine ointment (Rectogesic as 0.2% in Australia and 0.4% in UK) and diltiazem 2% (Anoheal in UK although still in Phase III development).


[[Botulinum toxin]] injection, administered by colorectal surgeons, can also be used to relax the sphincter muscle and its use for this condition was first investigated in 1993.<!--
==Indications==
  --><ref>{{cite journal |author=Jost W, Schimrigk K |title=Use of botulinum toxin in anal fissure |journal=Dis Colon Rectum |volume=36 |issue=10 |pages=974 |year=1993 |id=PMID 8404394}}</ref>
*Surgery is usually the mainstay of treatment and done for patients with either:
Combination of medical therapies may offer up to 98% cure rates,<!--
**Not responding to conservative measures
  --><ref>{{cite journal |author=Tranqui P, Trottier D, Victor C, Freeman J |title=Nonsurgical treatment of chronic anal fissure: nitroglycerin and dilatation versus nifedipine and botulinum toxin |journal=Canadian journal of surgery.  Journal canadien de chirurgie |volume=49 |issue=1 |pages=41-5 |year=2006 |pmid=16524142 |url=http://www.cma.ca/multimedia/staticContent/HTML/N0/l2/cjs/vol-49/issue-1/pdf/pg41.pdf |format=PDF}}</ref>
**Chronic anal fissures
These medical treatments are used as first line therapy in treating chronic anal fissures,<!--
**Fissures complicated by fistulas
  --><ref>{{cite journal |author=Haq Z, Rahman M, Chowdhury R, Baten M, Khatun M |title=Chemical sphincterotomy--first line of treatment for chronic anal fissure |journal=Mymensingh Med J |volume=14 |issue=1 |pages=88-90 |year=2005 |id=PMID 15695964}}</ref>
although a [[Cochrane Collaboration]] review of published research has questioned the effectiveness of medical treatments compared to surgery.<!--
  --><ref>{{cite journal |author=Nelson R |title=Non surgical therapy for anal fissure |journal=Cochrane database of systematic reviews (Online) |volume= |issue=4 |pages=CD003431 |year=2006 |pmid=17054170}}</ref>


===Surgical sphincterotomy===
==Surgery==
===Surgical Sphincterotomy===
Surgical intervention may be required for persisting deep anal fissures unresponsive to the above conservative measures. Procedures include:
Surgical intervention may be required for persisting deep anal fissures unresponsive to the above conservative measures. Procedures include:
*Internal lateral sphincterotomy or [[excision|excising]] a portion of the sphincter
*Lateral internal [[sphincterotomy]] is the gold standard surgical procedure. It increases fissure healing when compared to surgery like posterior [[sphincterotomy]], anal stretch and medical management.<ref name="pmid27041801">{{cite journal |vauthors=Schlichtemeier S, Engel A |title=Anal fissure |journal=Aust Prescr |volume=39 |issue=1 |pages=14–7 |year=2016 |pmid=27041801 |pmc=4816871 |doi=10.18773/austprescr.2016.007 |url=}}</ref><ref>http://www.surgwiki.com/wiki/Anal_and_perianal_disorders#Anal_fissure</ref><ref name="pmid25391392">{{cite journal |vauthors=Nelson RL |title=Anal fissure (chronic) |journal=BMJ Clin Evid |volume=2014 |issue= |pages= |year=2014 |pmid=25391392 |pmc=4229958 |doi= |url=}}</ref><ref>Jonas M, Scholefield JH. Anal fissure. In: Holzheimer RG, Mannick JA, editors. Surgical Treatment: Evidence-Based and Problem-Oriented. Munich: Zuckschwerdt; 2001. Available from: https://www.ncbi.nlm.nih.gov/books/NBK6878/</ref>
* Anal dilation or stretching of the anal canal is no longer recommended because of the unacceptably high incidence of [[fecal incontinence]].<ref>{{cite journal |author=Kotlarewsky M, Freeman JB, Cameron W, Grimard LJ |title=Anal intraepithelial dysplasia and squamous carcinoma in immunosuppressed patients |journal=Canadian journal of surgery.  Journal canadien de chirurgie |volume=44 |issue=6 |pages=450-4 |year=2001 |pmid=11764880 |doi= |url=http://www.cma.ca/multimedia/staticContent/HTML/N0/l2/cjs/vol-44/issue-6/pdf/pg450.pdf |format=PDF}}</ref> In addition, anal stretching can increase the rate of flatus incontinence.<ref>{{cite journal |author=Sadovsky R |title=Diagnosis and management of patients with anal fissures - Tips from Other Journals |journal=American Family Physician |year=2003 |month=1 April |volume=67 | issue=7 |pages=1608 |url=http://findarticles.com/p/articles/mi_m3225/is_7_67/ai_99410474 |format=Reprint}}</ref>  
* Anal dilation or stretching of the anal canal is no longer recommended because of the unacceptably high incidence of [[fecal incontinence]].<ref>{{cite journal |author=Kotlarewsky M, Freeman JB, Cameron W, Grimard LJ |title=Anal intraepithelial dysplasia and squamous carcinoma in immunosuppressed patients |journal=Canadian journal of surgery.  Journal canadien de chirurgie |volume=44 |issue=6 |pages=450-4 |year=2001 |pmid=11764880 |doi= |url=http://www.cma.ca/multimedia/staticContent/HTML/N0/l2/cjs/vol-44/issue-6/pdf/pg450.pdf |format=PDF}}</ref> In addition, anal stretching can increase the rate of flatus incontinence.<ref>{{cite journal |author=Sadovsky R |title=Diagnosis and management of patients with anal fissures - Tips from Other Journals |journal=American Family Physician |year=2003 |month=1 April |volume=67 | issue=7 |pages=1608 |url=http://findarticles.com/p/articles/mi_m3225/is_7_67/ai_99410474 |format=Reprint}}</ref>  


Despite the high success rate of these surgical procedures (~95%), there are potential side effects, which include: risks from [[anesthesia]], [[infection]] and anal leakage ([[fecal incontinence]]).
Despite the high success rate of these surgical procedures (~95%), there are potential side effects, which include risks from [[anesthesia]], [[infection]], and anal leakage ([[fecal incontinence]]).
*In people who have a high risk of developing incontinence, the procedures done include:<ref name="pmid25391392">{{cite journal |vauthors=Nelson RL |title=Anal fissure (chronic) |journal=BMJ Clin Evid |volume=2014 |issue= |pages= |year=2014 |pmid=25391392 |pmc=4229958 |doi= |url=}}</ref>
**Anal advancement flap
**[[Botulinum toxin]]


==Contraindications==
*[[Fecal incontinence]]
==References==
==References==
{{reflist|2}}
{{reflist|2}}
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[[Category:Medicine]]
[[Category:Surgery]]
[[Category:Gastroenterology]]
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Latest revision as of 20:24, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

Overview

Surgery is the option after trying the conservative and medical measures and its done in patients not responding to them, with chronic anal fissures and where fissures are complicated by fistulas and abscess. Lateral internal sphincterotomy is the procedure of choice. The complications of the surgery include fecal incontinence and therefore contraindicated in the patients having fecal incontinence. In these patients, anal advancement flap or Botulinum toxin is used.

Indications

  • Surgery is usually the mainstay of treatment and done for patients with either:
    • Not responding to conservative measures
    • Chronic anal fissures
    • Fissures complicated by fistulas

Surgery

Surgical Sphincterotomy

Surgical intervention may be required for persisting deep anal fissures unresponsive to the above conservative measures. Procedures include:

  • Lateral internal sphincterotomy is the gold standard surgical procedure. It increases fissure healing when compared to surgery like posterior sphincterotomy, anal stretch and medical management.[1][2][3][4]
  • Anal dilation or stretching of the anal canal is no longer recommended because of the unacceptably high incidence of fecal incontinence.[5] In addition, anal stretching can increase the rate of flatus incontinence.[6]

Despite the high success rate of these surgical procedures (~95%), there are potential side effects, which include risks from anesthesia, infection, and anal leakage (fecal incontinence).

  • In people who have a high risk of developing incontinence, the procedures done include:[3]

Contraindications

References

  1. Schlichtemeier S, Engel A (2016). "Anal fissure". Aust Prescr. 39 (1): 14–7. doi:10.18773/austprescr.2016.007. PMC 4816871. PMID 27041801.
  2. http://www.surgwiki.com/wiki/Anal_and_perianal_disorders#Anal_fissure
  3. 3.0 3.1 Nelson RL (2014). "Anal fissure (chronic)". BMJ Clin Evid. 2014. PMC 4229958. PMID 25391392.
  4. Jonas M, Scholefield JH. Anal fissure. In: Holzheimer RG, Mannick JA, editors. Surgical Treatment: Evidence-Based and Problem-Oriented. Munich: Zuckschwerdt; 2001. Available from: https://www.ncbi.nlm.nih.gov/books/NBK6878/
  5. Kotlarewsky M, Freeman JB, Cameron W, Grimard LJ (2001). "Anal intraepithelial dysplasia and squamous carcinoma in immunosuppressed patients" (PDF). Canadian journal of surgery. Journal canadien de chirurgie. 44 (6): 450–4. PMID 11764880.
  6. Sadovsky R (2003). "Diagnosis and management of patients with anal fissures - Tips from Other Journals" (Reprint). American Family Physician. 67 (7): 1608. Unknown parameter |month= ignored (help)

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