PKIA: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Underlinked|date=March 2014}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''cAMP-dependent protein kinase inhibitor alpha''' is a [[protein]] that in humans is encoded by the ''PKIA'' [[gene]].<ref name="pmid1770951">{{cite journal | vauthors = Olsen SR, Uhler MD | title = Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor | journal = Mol Endocrinol | volume = 5 | issue = 9 | pages = 1246–56 |date=Feb 1992 | pmid = 1770951 | pmc =  | doi =10.1210/mend-5-9-1246 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5569| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Protein kinase (cAMP-dependent, catalytic) inhibitor alpha
| HGNCid = 9017
| Symbol = PKIA
| AltSymbols =; PRKACN1
| OMIM = 606059
| ECnumber = 
| Homologene = 7473
| MGIid = 104747
| GeneAtlas_image1 = PBB_GE_PKIA_204612_at_tn.png
| Function = {{GNF_GO|id=GO:0004862 |text = cAMP-dependent protein kinase inhibitor activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006469 |text = negative regulation of protein kinase activity}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5569
    | Hs_Ensembl = ENSG00000171033
    | Hs_RefseqProtein = NP_006814
    | Hs_RefseqmRNA = NM_006823
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 79673149
    | Hs_GenLoc_end = 79677999
    | Hs_Uniprot = P61925
    | Mm_EntrezGene = 18767
    | Mm_Ensembl = ENSMUSG00000027499
    | Mm_RefseqmRNA = NM_008862
    | Mm_RefseqProtein = NP_032888
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 7349743
    | Mm_GenLoc_end = 7428439
    | Mm_Uniprot = Q3UTL0
  }}
}}
'''Protein kinase (cAMP-dependent, catalytic) inhibitor alpha''', also known as '''PKIA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5569| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5569| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Olsen SR, Uhler MD |title=Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinase. |journal=J. Biol. Chem. |volume=266 |issue= 17 |pages= 11158-62 |year= 1991 |pmid= 1710219 |doi=  }}
*{{cite journal  | vauthors=Olsen SR, Uhler MD |title=Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinase |journal=J. Biol. Chem. |volume=266 |issue= 17 |pages= 11158–62 |year= 1991 |pmid= 1710219 |doi=  }}
*{{cite journal | author=Olsen SR, Uhler MD |title=Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor. |journal=Mol. Endocrinol. |volume=5 |issue= 9 |pages= 1246-56 |year= 1992 |pmid= 1770951 |doi=  }}
*{{cite journal   |vauthors=Knighton DR, Zheng JH, Ten Eyck LF, etal |title=Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase |journal=Science |volume=253 |issue= 5018 |pages= 414–20 |year= 1991 |pmid= 1862343 |doi=10.1126/science.1862343 }}
*{{cite journal  | author=Knighton DR, Zheng JH, Ten Eyck LF, ''et al.'' |title=Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. |journal=Science |volume=253 |issue= 5018 |pages= 414-20 |year= 1991 |pmid= 1862343 |doi=  }}
*{{cite journal  | vauthors=Van Patten SM, Heisermann GJ, Cheng HC, Walsh DA |title=Tyrosine kinase catalyzed phosphorylation and inactivation of the inhibitor protein of the cAMP-dependent protein kinase |journal=J. Biol. Chem. |volume=262 |issue= 7 |pages= 3398–403 |year= 1987 |pmid= 2434500 |doi=  }}
*{{cite journal  | author=Van Patten SM, Heisermann GJ, Cheng HC, Walsh DA |title=Tyrosine kinase catalyzed phosphorylation and inactivation of the inhibitor protein of the cAMP-dependent protein kinase. |journal=J. Biol. Chem. |volume=262 |issue= 7 |pages= 3398-403 |year= 1987 |pmid= 2434500 |doi=  }}
*{{cite journal  | vauthors=Scott JD, Fischer EH, Demaille JG, Krebs EG |title=Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 13 |pages= 4379–83 |year= 1985 |pmid= 2989819 |doi=10.1073/pnas.82.13.4379  | pmc=390417 }}
*{{cite journal  | author=Scott JD, Fischer EH, Demaille JG, Krebs EG |title=Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 13 |pages= 4379-83 |year= 1985 |pmid= 2989819 |doi=  }}
*{{cite journal  | vauthors=Scott JD, Glaccum MB, Fischer EH, Krebs EG |title=Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 6 |pages= 1613–6 |year= 1986 |pmid= 3456605 |doi=10.1073/pnas.83.6.1613  | pmc=323133 }}
*{{cite journal  | author=Scott JD, Glaccum MB, Fischer EH, Krebs EG |title=Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 6 |pages= 1613-6 |year= 1986 |pmid= 3456605 |doi=  }}
*{{cite journal  | vauthors=Wen W, Taylor SS, Meinkoth JL |title=The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated |journal=J. Biol. Chem. |volume=270 |issue= 5 |pages= 2041–6 |year= 1995 |pmid= 7836431 |doi=10.1074/jbc.270.5.2041 }}
*{{cite journal  | author=Wen W, Taylor SS, Meinkoth JL |title=The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated. |journal=J. Biol. Chem. |volume=270 |issue= 5 |pages= 2041-6 |year= 1995 |pmid= 7836431 |doi=  }}
*{{cite journal   |vauthors=Baude EJ, Dignam SS, Olsen SR, etal |title=Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 2316–23 |year= 1994 |pmid= 7905001 |doi=  }}
*{{cite journal | author=Baude EJ, Dignam SS, Olsen SR, ''et al.'' |title=Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor. |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 2316-23 |year= 1994 |pmid= 7905001 |doi=  }}
*{{cite journal  | vauthors=Baude EJ, Dignam SS, Reimann EM, Uhler MD |title=Evidence for the importance of hydrophobic residues in the interactions between the cAMP-dependent protein kinase catalytic subunit and the protein kinase inhibitors |journal=J. Biol. Chem. |volume=269 |issue= 27 |pages= 18128–33 |year= 1994 |pmid= 8027074 |doi=  }}
*{{cite journal  | author=Baude EJ, Dignam SS, Reimann EM, Uhler MD |title=Evidence for the importance of hydrophobic residues in the interactions between the cAMP-dependent protein kinase catalytic subunit and the protein kinase inhibitors. |journal=J. Biol. Chem. |volume=269 |issue= 27 |pages= 18128-33 |year= 1994 |pmid= 8027074 |doi=  }}
*{{cite journal  | vauthors=Fritz CC, Green MR |title=HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs |journal=Curr. Biol. |volume=6 |issue= 7 |pages= 848–54 |year= 1997 |pmid= 8805303 |doi=10.1016/S0960-9822(02)00608-5 }}
*{{cite journal  | author=Fritz CC, Green MR |title=HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs. |journal=Curr. Biol. |volume=6 |issue= 7 |pages= 848-54 |year= 1997 |pmid= 8805303 |doi=  }}
*{{cite journal   |vauthors=Zimmermann B, Chiorini JA, Ma Y, etal |title=PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I |journal=J. Biol. Chem. |volume=274 |issue= 9 |pages= 5370–8 |year= 1999 |pmid= 10026146 |doi=10.1074/jbc.274.9.5370 }}
*{{cite journal | author=Zimmermann B, Chiorini JA, Ma Y, ''et al.'' |title=PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I. |journal=J. Biol. Chem. |volume=274 |issue= 9 |pages= 5370-8 |year= 1999 |pmid= 10026146 |doi=  }}
*{{cite journal   |vauthors=Yu J, Yu L, Chen Z, etal |title=Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors |journal=Brain Res. Mol. Brain Res. |volume=99 |issue= 2 |pages= 145–9 |year= 2002 |pmid= 11978406 |doi=10.1016/S0169-328X(02)00104-3 }}
*{{cite journal | author=Yu J, Yu L, Chen Z, ''et al.'' |title=Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors. |journal=Brain Res. Mol. Brain Res. |volume=99 |issue= 2 |pages= 145-9 |year= 2002 |pmid= 11978406 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gassel M, Breitenlechner CB, Rüger P, etal |title=Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT) |journal=J. Mol. Biol. |volume=329 |issue= 5 |pages= 1021–34 |year= 2003 |pmid= 12798691 |doi=10.1016/S0022-2836(03)00518-7 }}
*{{cite journal | author=Gassel M, Breitenlechner CB, Rüger P, ''et al.'' |title=Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT). |journal=J. Mol. Biol. |volume=329 |issue= 5 |pages= 1021-34 |year= 2003 |pmid= 12798691 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{WikiDoc Sources}}
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
 
{{gene-8-stub}}

Latest revision as of 18:13, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

cAMP-dependent protein kinase inhibitor alpha is a protein that in humans is encoded by the PKIA gene.[1][2]

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported.[2]

References

  1. ↑ Olsen SR, Uhler MD (Feb 1992). "Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor". Mol Endocrinol. 5 (9): 1246–56. doi:10.1210/mend-5-9-1246. PMID 1770951.
  2. ↑ 2.0 2.1 "Entrez Gene: PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=PKIA&oldid=1422257"