HLA-B associated transcript 3: Difference between revisions

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{Infobox_gene}}
{{GNF_Protein_box
'''Large proline-rich protein BAT3''' is a [[protein]] that in humans is encoded by the ''BAT3'' [[gene]].<ref name="pmid2156268">{{cite journal |vauthors=Banerji J, Sands J, Strominger JL, Spies T | title = A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain | journal = Proc Natl Acad Sci U S A | volume = 87 | issue = 6 | pages = 2374–8 |date=Apr 1990 | pmid = 2156268 | pmc = 53689 | doi =10.1073/pnas.87.6.2374 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BAT3 HLA-B associated transcript 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7917| accessdate = }}</ref>
| image = PBB_Protein_BAT3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wx9.
| PDB = {{PDB2|1wx9}}
| Name = HLA-B associated transcript 3
| HGNCid = 13919
| Symbol = BAT3
| AltSymbols =; D6S52E; G3
| OMIM = 142590
| ECnumber =
| Homologene = 3409
| MGIid = 1919439
| GeneAtlas_image1 = PBB_GE_BAT3_213318_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_BAT3_201255_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_BAT3_210208_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006464 |text = protein modification process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7917
    | Hs_Ensembl = ENSG00000204463
    | Hs_RefseqProtein = NP_004630
    | Hs_RefseqmRNA = NM_004639
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 31714784
    | Hs_GenLoc_end = 31728519
    | Hs_Uniprot = P46379
    | Mm_EntrezGene = 224727
    | Mm_Ensembl = ENSMUSG00000024392
    | Mm_RefseqmRNA = NM_057171
    | Mm_RefseqProtein = NP_476512
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 34743298
    | Mm_GenLoc_end = 34755292
    | Mm_Uniprot = Q3UF95
  }}
}}
'''HLA-B associated transcript 3''', also known as '''BAT3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BAT3 HLA-B associated transcript 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7917| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is a nuclear protein. It has been implicated in the control of apoptosis and regulating heat shock protein. There are three alternatively spliced transcript variants described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: BAT3 HLA-B associated transcript 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7917| accessdate = }}</ref>
| summary_text = A [[gene cluster|cluster of genes]], BAT1-BAT5, has been localized in the vicinity of the genes for [[TNF alpha]] and TNF beta. These genes are all within the human [[major histocompatibility complex]] class III region. The protein encoded by this gene is a [[nuclear protein]]. It has been implicated in the control of [[apoptosis]] and regulating [[heat shock protein]]. There are three alternatively spliced [[transcript variants]] described for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Takayama S, Reed JC |title=Molecular chaperone targeting and regulation by BAG family proteins. |journal=Nat. Cell Biol. |volume=3 |issue= 10 |pages= E237-41 |year= 2001 |pmid= 11584289 |doi= 10.1038/ncb1001-e237 }}
*{{cite journal  |vauthors=Takayama S, Reed JC |title=Molecular chaperone targeting and regulation by BAG family proteins |journal=Nat. Cell Biol. |volume=3 |issue= 10 |pages= E237–41 |year= 2001 |pmid= 11584289 |doi= 10.1038/ncb1001-e237 }}
*{{cite journal  | author=Cross SJ, Tonks S, Trowsdale J, Campbell RD |title=Novel detection of restriction fragment length polymorphisms in the human major histocompatibility complex. |journal=Immunogenetics |volume=34 |issue= 6 |pages= 376-84 |year= 1992 |pmid= 1684176 |doi=  }}
*{{cite journal  |vauthors=Cross SJ, Tonks S, Trowsdale J, Campbell RD |title=Novel detection of restriction fragment length polymorphisms in the human major histocompatibility complex |journal=Immunogenetics |volume=34 |issue= 6 |pages= 376–84 |year= 1992 |pmid= 1684176 |doi=10.1007/BF01787488 }}
*{{cite journal  | author=Banerji J, Sands J, Strominger JL, Spies T |title=A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 6 |pages= 2374-8 |year= 1990 |pmid= 2156268 |doi= }}
*{{cite journal  |vauthors=Spies T, Bresnahan M, Strominger JL |title=Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 22 |pages= 8955–8 |year= 1989 |pmid= 2813433 |doi=10.1073/pnas.86.22.8955  | pmc=298409  }}
*{{cite journal  | author=Spies T, Bresnahan M, Strominger JL |title=Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 22 |pages= 8955-8 |year= 1989 |pmid= 2813433 |doi=  }}
*{{cite journal  | author=Spies T |title=A new cluster of genes within the human major histocompatibility complex |journal=Science |volume=243 |issue= 4888 |pages= 214–7 |year= 1989 |pmid= 2911734 |doi=10.1126/science.2911734 |name-list-format=vanc| author2=Blanck G | author3=Bresnahan M | display-authors=3  | last4=Sands  | first4=J  | last5=Strominger  | first5=J. }}
*{{cite journal  | author=Spies T, Blanck G, Bresnahan M, ''et al.'' |title=A new cluster of genes within the human major histocompatibility complex. |journal=Science |volume=243 |issue= 4888 |pages= 214-7 |year= 1989 |pmid= 2911734 |doi=  }}
*{{cite journal  | author=Ozaki T |title=Cloning and characterization of rat BAT3 cDNA |journal=DNA Cell Biol. |volume=18 |issue= 6 |pages= 503–12 |year= 1999 |pmid= 10390159 |doi= 10.1089/104454999315222 |name-list-format=vanc| author2=Hanaoka E  | author3=Naka M  | display-authors=3  | last4=Nakagawara  | first4=Akira  | last5=Sakiyama  | first5=Shigeru }}
*{{cite journal  | author=Ozaki T, Hanaoka E, Naka M, ''et al.'' |title=Cloning and characterization of rat BAT3 cDNA. |journal=DNA Cell Biol. |volume=18 |issue= 6 |pages= 503-12 |year= 1999 |pmid= 10390159 |doi= 10.1089/104454999315222 }}
*{{cite journal  |vauthors=Thress K, Song J, Morimoto RI, Kornbluth S |title=Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper |journal=EMBO J. |volume=20 |issue= 5 |pages= 1033–41 |year= 2001 |pmid= 11230127 |doi= 10.1093/emboj/20.5.1033  | pmc=145500 }}
*{{cite journal  | author=Thress K, Song J, Morimoto RI, Kornbluth S |title=Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. |journal=EMBO J. |volume=20 |issue= 5 |pages= 1033-41 |year= 2001 |pmid= 11230127 |doi= 10.1093/emboj/20.5.1033 }}
*{{cite journal  |vauthors=Manchen ST, Hubberstey AV |title=Human Scythe contains a functional nuclear localization sequence and remains in the nucleus during staurosporine-induced apoptosis |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 5 |pages= 1075–82 |year= 2001 |pmid= 11587531 |doi= 10.1006/bbrc.2001.5701 }}
*{{cite journal  | author=Manchen ST, Hubberstey AV |title=Human Scythe contains a functional nuclear localization sequence and remains in the nucleus during staurosporine-induced apoptosis. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 5 |pages= 1075-82 |year= 2001 |pmid= 11587531 |doi= 10.1006/bbrc.2001.5701 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Mungall AJ |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055  |name-list-format=vanc| author2=Palmer SA | author3=Sims SK  | display-authors=3  | last4=Edwards  | first4=C. A. | last5=Ashurst  | first5=J. L.  | last6=Wilming  | first6=L.  | last7=Jones  | first7=M. C.  | last8=Horton  | first8=R. | last9=Hunt  | first9=S. E. }}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | author=Xie T |title=Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621–36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 | pmc=403804  |name-list-format=vanc| author2=Rowen L  | author3=Aguado B  | display-authors=3  | last4=Ahearn  | first4=ME  | last5=Madan  | first5=A  | last6=Qin  | first6=S  | last7=Campbell  | first7=RD  | last8=Hood  | first8=L }}
*{{cite journal | author=Xie T, Rowen L, Aguado B, ''et al.'' |title=Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621-36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 }}
*{{cite journal  | author=Lehner B |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0  |name-list-format=vanc| author2=Semple JI | author3=Brown SE  | display-authors=3  | last4=Counsell  | first4=Damian  | last5=Campbell  | first5=R.Duncan  | last6=Sanderson  | first6=Christopher M  }}
*{{cite journal | author=Lehner B, Semple JI, Brown SE, ''et al.'' |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153-67 |year= 2004 |pmid= 14667819 |doi=  }}
*{{cite journal  |vauthors=Wu YH, Shih SF, Lin JY |title=Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3 |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 19264–75 |year= 2004 |pmid= 14960581 |doi= 10.1074/jbc.M307049200 }}
*{{cite journal  | author=Wu YH, Shih SF, Lin JY |title=Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 19264-75 |year= 2004 |pmid= 14960581 |doi= 10.1074/jbc.M307049200 }}
*{{cite journal  |vauthors=Lehner B, Sanderson CM |title=A Protein Interaction Framework for Human mRNA Degradation |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004  | pmc=442147 }}
*{{cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal  | author=Colland F |title=Functional Proteomics Mapping of a Human Signaling Pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104  | pmc=442148  |name-list-format=vanc| author2=Jacq X  | author3=Trouplin V  | display-authors=3  | last4=Mougin  | first4=C  | last5=Groizeleau  | first5=C  | last6=Hamburger  | first6=A  | last7=Meil  | first7=A  | last8=Wojcik  | first8=J  | last9=Legrain  | first9=P }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446  |name-list-format=vanc| author2=Jedrychowski M  | author3=Schwartz D  | display-authors=3  | last4=Elias  | first4=JE  | last5=Villén  | first5=J  | last6=Li  | first6=J  | last7=Cohn  | first7=MA  | last8=Cantley  | first8=LC  | last9=Gygi  | first9=SP }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  |vauthors=Kumar R, Lutz W, Frank E, Im HJ |title=Immediate early gene X-1 interacts with proteins that modulate apoptosis |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 4 |pages= 1293–8 |year= 2004 |pmid= 15451437  | pmc=2895269 |doi= 10.1016/j.bbrc.2004.09.006 }}
*{{cite journal | author=Kumar R, Lutz W, Frank E, Im HJ |title=Immediate early gene X-1 interacts with proteins that modulate apoptosis. |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 4 |pages= 1293-8 |year= 2004 |pmid= 15451437 |doi= 10.1016/j.bbrc.2004.09.006 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Stelzl U |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |name-list-format=vanc| author2=Worm U  | author3=Lalowski M  | display-authors=3  | last4=Haenig  | first4=Christian  | last5=Brembeck  | first5=Felix H.  | last6=Goehler  | first6=Heike  | last7=Stroedicke  | first7=Martin  | last8=Zenkner  | first8=Martina  | last9=Schoenherr  | first9=Anke }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=7917}}
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Latest revision as of 17:13, 28 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Large proline-rich protein BAT3 is a protein that in humans is encoded by the BAT3 gene.[1][2]

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is a nuclear protein. It has been implicated in the control of apoptosis and regulating heat shock protein. There are three alternatively spliced transcript variants described for this gene.[2]

References

  1. ↑ Banerji J, Sands J, Strominger JL, Spies T (Apr 1990). "A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain". Proc Natl Acad Sci U S A. 87 (6): 2374–8. doi:10.1073/pnas.87.6.2374. PMC 53689. PMID 2156268.
  2. ↑ 2.0 2.1 "Entrez Gene: BAT3 HLA-B associated transcript 3".

Further reading



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