CHST4: Difference between revisions

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{{Underlinked|date=May 2016}}
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{{Infobox_gene}}
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'''Carbohydrate sulfotransferase 4''' is an [[enzyme]] that in humans is encoded by the ''CHST4'' [[gene]].<ref name="pmid10330415">{{cite journal | vauthors = Bistrup A, Bhakta S, Lee JK, Belov YY, Gunn MD, Zuo FR, Huang CC, Kannagi R, Rosen SD, Hemmerich S | title = Sulfotransferases of Two Specificities Function in the Reconstitution of High Endothelial Cell Ligands for L-selectin | journal = J Cell Biol | volume = 145 | issue = 4 | pages = 899–910 |date=Jul 1999 | pmid = 10330415 | pmc = 2133194 | doi =10.1083/jcb.145.4.899 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10164| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
| HGNCid = 1972
| Symbol = CHST4
| AltSymbols =; LSST
| OMIM = 
| ECnumber = 
| Homologene = 4216
| MGIid = 1349479
| GeneAtlas_image1 = PBB_GE_CHST4_220446_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001517 |text = N-acetylglucosamine 6-O-sulfotransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005802 |text = trans-Golgi network}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0031228 |text = intrinsic to Golgi membrane}}
  | Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006044 |text = N-acetylglucosamine metabolic process}} {{GNF_GO|id=GO:0006477 |text = protein amino acid sulfation}} {{GNF_GO|id=GO:0006790 |text = sulfur metabolic process}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10164
    | Hs_Ensembl = ENSG00000140835
    | Hs_RefseqProtein = NP_005760
    | Hs_RefseqmRNA = NM_005769
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 70117560
    | Hs_GenLoc_end = 70129910
    | Hs_Uniprot = Q8NCG5
    | Mm_EntrezGene = 26887
    | Mm_Ensembl = ENSMUSG00000035930
    | Mm_RefseqmRNA = NM_011998
    | Mm_RefseqProtein = NP_036128
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 112918282
    | Mm_GenLoc_end = 112928869
    | Mm_Uniprot = Q9R1I1
  }}
}}
'''Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4''', also known as '''CHST4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10164| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bernstein HB, Compans RW |title=Sulfation of the human immunodeficiency virus envelope glycoprotein. |journal=J. Virol. |volume=66 |issue= 12 |pages= 6953-9 |year= 1992 |pmid= 1433500 |doi=  }}
*{{cite journal  | vauthors=Bernstein HB, Compans RW |title=Sulfation of the human immunodeficiency virus envelope glycoprotein |journal=J. Virol. |volume=66 |issue= 12 |pages= 6953–9 |year= 1992 |pmid= 1433500 |doi= | pmc=240329 }}
*{{cite journal  | author=Shilatifard A, Merkle RK, Helland DE, ''et al.'' |title=Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine. |journal=J. Virol. |volume=67 |issue= 2 |pages= 943-52 |year= 1993 |pmid= 8419650 |doi=  }}
*{{cite journal  | author=Shilatifard A |title=Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine |journal=J. Virol. |volume=67 |issue= 2 |pages= 943–52 |year= 1993 |pmid= 8419650 |doi=  | pmc=237448 |name-list-format=vanc| author2=Merkle RK  | author3=Helland DE  | display-authors=3  | last4=Welles  | first4=JL  | last5=Haseltine  | first5=WA  | last6=Cummings  | first6=RD }}
*{{cite journal | author=Bistrup A, Bhakta S, Lee JK, ''et al.'' |title=Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin. |journal=J. Cell Biol. |volume=145 |issue= 4 |pages= 899-910 |year= 1999 |pmid= 10330415 |doi=  }}
*{{cite journal  | author=Hemmerich S |title=Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family |journal=Glycobiology |volume=11 |issue= 1 |pages= 75–87 |year= 2001 |pmid= 11181564 |doi=10.1093/glycob/11.1.75 |name-list-format=vanc| author2=Lee JK | author3=Bhakta S  | display-authors=3  | last4=Bistrup  | first4=A  | last5=Ruddle  | first5=NR  | last6=Rosen  | first6=SD }}
*{{cite journal  | author=Hemmerich S, Lee JK, Bhakta S, ''et al.'' |title=Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family. |journal=Glycobiology |volume=11 |issue= 1 |pages= 75-87 |year= 2001 |pmid= 11181564 |doi=  }}
*{{cite journal  | author=Li X |title=CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin |journal=J. Leukoc. Biol. |volume=69 |issue= 4 |pages= 565–74 |year= 2001 |pmid= 11310842 |doi=  |name-list-format=vanc| author2=Tu L | author3=Murphy PG  | display-authors=3  | last4=Kadono  | first4=T  | last5=Steeber  | first5=DA  | last6=Tedder  | first6=TF  }}
*{{cite journal | author=Li X, Tu L, Murphy PG, ''et al.'' |title=CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin. |journal=J. Leukoc. Biol. |volume=69 |issue= 4 |pages= 565-74 |year= 2001 |pmid= 11310842 |doi=  }}
*{{cite journal  | author=Yeh JC |title=Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase |journal=Cell |volume=105 |issue= 7 |pages= 957–69 |year= 2001 |pmid= 11439191 |doi=10.1016/S0092-8674(01)00394-4 |name-list-format=vanc| author2=Hiraoka N  | author3=Petryniak B  | display-authors=3  | last4=Nakayama  | first4=Jun  | last5=Ellies  | first5=Lesley G.  | last6=Rabuka  | first6=David  | last7=Hindsgaul  | first7=Ole  | last8=Marth  | first8=Jamey D.  | last9=Lowe  | first9=John B. }}
*{{cite journal  | author=Yeh JC, Hiraoka N, Petryniak B, ''et al.'' |title=Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase. |journal=Cell |volume=105 |issue= 7 |pages= 957-69 |year= 2001 |pmid= 11439191 |doi=  }}
*{{cite journal  | author=Uchimura K |title=Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression |journal=J. Biol. Chem. |volume=277 |issue= 6 |pages= 3979–84 |year= 2002 |pmid= 11726653 |doi= 10.1074/jbc.M106587200 |name-list-format=vanc| author2=El-Fasakhany FM  | author3=Hori M  | display-authors=3  | last4=Hemmerich  | first4=S  | last5=Blink  | first5=SE  | last6=Kansas | first6=GS  | last7=Kanamori  | first7=A  | last8=Kumamoto  | first8=K  | last9=Kannagi  | first9=R }}
*{{cite journal | author=Uchimura K, El-Fasakhany FM, Hori M, ''et al.'' |title=Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression. |journal=J. Biol. Chem. |volume=277 |issue= 6 |pages= 3979-84 |year= 2002 |pmid= 11726653 |doi= 10.1074/jbc.M106587200 }}
*{{cite journal  | vauthors=Seko A, Nagata K, Yonezawa S, Yamashita K |title=Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma |journal=Glycobiology |volume=12 |issue= 6 |pages= 379–88 |year= 2003 |pmid= 12107080 |doi=10.1093/glycob/12.6.379  }}
*{{cite journal | author=Seko A, Nagata K, Yonezawa S, Yamashita K |title=Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma. |journal=Glycobiology |volume=12 |issue= 6 |pages= 379-88 |year= 2003 |pmid= 12107080 |doi=  }}
*{{cite journal  | vauthors=Akama TO, Misra AK, Hindsgaul O, Fukuda MN |title=Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42505–13 |year= 2003 |pmid= 12218059 |doi= 10.1074/jbc.M207412200 }}
*{{cite journal  | author=Akama TO, Misra AK, Hindsgaul O, Fukuda MN |title=Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42505-13 |year= 2003 |pmid= 12218059 |doi= 10.1074/jbc.M207412200 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=de Graffenried CL, Bertozzi CR |title=Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis |journal=J. Biol. Chem. |volume=278 |issue= 41 |pages= 40282–95 |year= 2003 |pmid= 12855678 |doi= 10.1074/jbc.M304928200 }}
*{{cite journal | author=de Graffenried CL, Bertozzi CR |title=Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis. |journal=J. Biol. Chem. |volume=278 |issue= 41 |pages= 40282-95 |year= 2003 |pmid= 12855678 |doi= 10.1074/jbc.M304928200 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=de Graffenried CL, Bertozzi CR |title=The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40035–43 |year= 2004 |pmid= 15220337 |doi= 10.1074/jbc.M405709200 }}
*{{cite journal  | author=de Graffenried CL, Bertozzi CR |title=The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40035-43 |year= 2004 |pmid= 15220337 |doi= 10.1074/jbc.M405709200 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Otsuki T |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117  |name-list-format=vanc| author2=Ota T  | author3=Nishikawa T  | display-authors=3  | last4=Hayashi  | first4=K  | last5=Suzuki  | first5=Y  | last6=Yamamoto  | first6=J  | last7=Wakamatsu  | first7=A  | last8=Kimura  | first8=K  | last9=Sakamoto  | first9=K }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal  | author=Timson G |title=High level expression of N-acetylgluosamine-6-O-sulfotransferase is characteristic of a subgroup of paediatric precursor-B acute lymphoblastic leukaemia |journal=Cancer Lett. |volume=242 |issue= 2 |pages= 239–44 |year= 2006 |pmid= 16386360 |doi= 10.1016/j.canlet.2005.11.012  |name-list-format=vanc| author2=Banavali S  | author3=Gutierrez MI  | display-authors=3  | last4=Magrath  | first4=Iain  | last5=Bhatia  | first5=Kishor G.  | last6=Goyns  | first6=Malcolm H. }}
*{{cite journal  | author=Timson G, Banavali S, Gutierrez MI, ''et al.'' |title=High level expression of N-acetylgluosamine-6-O-sulfotransferase is characteristic of a subgroup of paediatric precursor-B acute lymphoblastic leukaemia. |journal=Cancer Lett. |volume=242 |issue= 2 |pages= 239-44 |year= 2006 |pmid= 16386360 |doi= 10.1016/j.canlet.2005.11.012 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|CHST4}}
* {{UCSC gene details|CHST4}}
 
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Latest revision as of 09:42, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Carbohydrate sulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene.[1][2]


References

  1. ↑ Bistrup A, Bhakta S, Lee JK, Belov YY, Gunn MD, Zuo FR, Huang CC, Kannagi R, Rosen SD, Hemmerich S (Jul 1999). "Sulfotransferases of Two Specificities Function in the Reconstitution of High Endothelial Cell Ligands for L-selectin". J Cell Biol. 145 (4): 899–910. doi:10.1083/jcb.145.4.899. PMC 2133194. PMID 10330415.
  2. ↑ "Entrez Gene: CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4".

Further reading

External links



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