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{{Infobox_gene}}
{{PBB_Controls
'''Choline kinase alpha''' is an [[enzyme]] that in humans is encoded by the ''CHKA'' [[gene]].<ref name="pmid1618328">{{cite journal | vauthors = Hosaka K, Tanaka S, Nikawa J, Yamashita S | title = Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation | journal = FEBS Lett | volume = 304 | issue = 2–3 | pages = 229–32 |date=Aug 1992 | pmid = 1618328 | pmc =  | doi =10.1016/0014-5793(92)80625-Q }}</ref><ref name="pmid15003397">{{cite journal | vauthors = Aoyama C, Liao H, Ishidate K | title = Structure and function of choline kinase isoforms in mammalian cells | journal = Prog Lipid Res | volume = 43 | issue = 3 | pages = 266–81 |date=Mar 2004 | pmid = 15003397 | pmc =  | doi = 10.1016/j.plipres.2003.12.001 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CHKA choline kinase alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1119| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CHKA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2cko.
| PDB = {{PDB2|2cko}}, {{PDB2|2ckp}}, {{PDB2|2ckq}}, {{PDB2|2i7q}}
| Name = Choline kinase alpha
| HGNCid = 1937
| Symbol = CHKA
| AltSymbols =; CHK; CKI
| OMIM = 118491
| ECnumber =
| Homologene = 88575
| MGIid = 107760
  | GeneAtlas_image1 = PBB_GE_CHKA_204233_s_at_tn.png
  | GeneAtlas_image2 = PBB_GE_CHKA_204266_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004103 |text = choline kinase activity}} {{GNF_GO|id=GO:0004104 |text = cholinesterase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0045735 |text = nutrient reservoir activity}}
| Component =  
  | Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006656 |text = phosphatidylcholine biosynthetic process}} {{GNF_GO|id=GO:0006869 |text = lipid transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1119
    | Hs_Ensembl = ENSG00000110721
    | Hs_RefseqProtein = NP_001268
    | Hs_RefseqmRNA = NM_001277
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 67576926
    | Hs_GenLoc_end = 67645434
    | Hs_Uniprot = P35790
    | Mm_EntrezGene = 12660
    | Mm_Ensembl = ENSMUSG00000024843
    | Mm_RefseqmRNA = NM_001025566
    | Mm_RefseqProtein = NP_001020737
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 3851773
    | Mm_GenLoc_end = 3894369
    | Mm_Uniprot = Q5J2U5
  }}
}}
'''Choline kinase alpha''', also known as '''CHKA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CHKA choline kinase alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1119| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: CHKA choline kinase alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1119| accessdate = }}</ref>
| summary_text = The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez"/>
 
In melanocytic cells CHKA gene expression may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x |display-authors=etal}}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CHKA}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Aoyama C, Liao H, Ishidate K |title=Structure and function of choline kinase isoforms in mammalian cells. |journal=Prog. Lipid Res. |volume=43 |issue= 3 |pages= 266-81 |year= 2004 |pmid= 15003397 |doi= 10.1016/j.plipres.2003.12.001 }}
*{{cite journal  | vauthors=Spanner S, Ansell GB |title=Choline kinase and ethanolamine kinase activity in the cytosol of nerve endings from rat forebrain |journal=Biochem. J. |volume=178 |issue= 3 |pages= 753–60 |year= 1979 |pmid= 36885 |doi= | pmc=1186576 }}
*{{cite journal  | author=Spanner S, Ansell GB |title=Choline kinase and ethanolamine kinase activity in the cytosol of nerve endings from rat forebrain. |journal=Biochem. J. |volume=178 |issue= 3 |pages= 753-60 |year= 1979 |pmid= 36885 |doi=  }}
*{{cite journal  | vauthors=Spanner S, Ansell GB |title=Choline and ethanolamine kinase activity in the cytoplasm of nerve endings from rat forebrain |journal=Adv. Exp. Med. Biol. |volume=101 |issue=  |pages= 237–45 |year= 1978 |pmid= 208357 |doi=  10.1007/978-1-4615-9071-2_23}}
*{{cite journal  | author=Spanner S, Ansell GB |title=Choline and ethanolamine kinase activity in the cytoplasm of nerve endings from rat forebrain. |journal=Adv. Exp. Med. Biol. |volume=101 |issue=  |pages= 237-45 |year= 1978 |pmid= 208357 |doi=  }}
*{{cite journal  | vauthors=Kaplan O, Cohen JS |title=Lymphocyte activation-31P magnetic resonance studies of energy metabolism and phospholipid pathways |journal=Immunomethods |volume=4 |issue= 2 |pages= 139–47 |year= 1994 |pmid= 8069533 |doi=10.1006/immu.1994.1015 }}
*{{cite journal  | author=Hosaka K, Tanaka S, Nikawa J, Yamashita S |title=Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation. |journal=FEBS Lett. |volume=304 |issue= 2-3 |pages= 229-32 |year= 1992 |pmid= 1618328 |doi=  }}
*{{cite journal  | vauthors=Price DJ, Rivnay B, Fu Y |title=Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes |journal=J. Biol. Chem. |volume=272 |issue= 9 |pages= 5915–20 |year= 1997 |pmid= 9038210 |doi=10.1074/jbc.272.9.5915 |display-authors=etal}}
*{{cite journal  | author=Kaplan O, Cohen JS |title=Lymphocyte activation-31P magnetic resonance studies of energy metabolism and phospholipid pathways. |journal=Immunomethods |volume=4 |issue= 2 |pages= 139-47 |year= 1994 |pmid= 8069533 |doi=  }}
*{{cite journal  | vauthors=Ross BM, Moszczynska A, Blusztajn JK |title=Phospholipid biosynthetic enzymes in human brain |journal=Lipids |volume=32 |issue= 4 |pages= 351–8 |year= 1997 |pmid= 9113621 |doi=10.1007/s11745-997-0044-x |display-authors=etal}}
*{{cite journal  | author=Price DJ, Rivnay B, Fu Y, ''et al.'' |title=Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. |journal=J. Biol. Chem. |volume=272 |issue= 9 |pages= 5915-20 |year= 1997 |pmid= 9038210 |doi=  }}
*{{cite journal  | vauthors=Nakagami K, Uchida T, Ohwada S |title=Increased choline kinase activity and elevated phosphocholine levels in human colon cancer |journal=Jpn. J. Cancer Res. |volume=90 |issue= 4 |pages= 419–24 |year= 1999 |pmid= 10363580 |doi=  10.1111/j.1349-7006.1999.tb00764.x|display-authors=etal}}
*{{cite journal  | author=Ross BM, Moszczynska A, Blusztajn JK, ''et al.'' |title=Phospholipid biosynthetic enzymes in human brain. |journal=Lipids |volume=32 |issue= 4 |pages= 351-8 |year= 1997 |pmid= 9113621 |doi=  }}
*{{cite journal  | vauthors=Ramírez de Molina A, Penalva V, Lucas L, Lacal JC |title=Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K |journal=Oncogene |volume=21 |issue= 6 |pages= 937–46 |year= 2002 |pmid= 11840339 |doi= 10.1038/sj.onc.1205144 }}
*{{cite journal  | author=Nakagami K, Uchida T, Ohwada S, ''et al.'' |title=Increased choline kinase activity and elevated phosphocholine levels in human colon cancer. |journal=Jpn. J. Cancer Res. |volume=90 |issue= 4 |pages= 419-24 |year= 1999 |pmid= 10363580 |doi=  }}
*{{cite journal  | vauthors=Dubois T, Howell S, Zemlickova E, Aitken A |title=Identification of casein kinase Ialpha interacting protein partners |journal=FEBS Lett. |volume=517 |issue= 1–3 |pages= 167–71 |year= 2002 |pmid= 12062430 |doi=10.1016/S0014-5793(02)02614-5 }}
*{{cite journal  | author=Ramírez de Molina A, Penalva V, Lucas L, Lacal JC |title=Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K. |journal=Oncogene |volume=21 |issue= 6 |pages= 937-46 |year= 2002 |pmid= 11840339 |doi= 10.1038/sj.onc.1205144 }}
*{{cite journal  | vauthors=Ramírez de Molina A, Gutiérrez R, Ramos MA |title=Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy |journal=Oncogene |volume=21 |issue= 27 |pages= 4317–22 |year= 2002 |pmid= 12082619 |doi= 10.1038/sj.onc.1205556 |display-authors=etal}}
*{{cite journal  | author=Dubois T, Howell S, Zemlickova E, Aitken A |title=Identification of casein kinase Ialpha interacting protein partners. |journal=FEBS Lett. |volume=517 |issue= 1-3 |pages= 167-71 |year= 2002 |pmid= 12062430 |doi=  }}
*{{cite journal  | vauthors=Ramírez de Molina A, Rodríguez-González A, Gutiérrez R |title=Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 3 |pages= 580–3 |year= 2002 |pmid= 12176020 |doi=10.1016/S0006-291X(02)00920-8 |display-authors=etal}}
*{{cite journal  | author=Ramírez de Molina A, Gutiérrez R, Ramos MA, ''et al.'' |title=Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy. |journal=Oncogene |volume=21 |issue= 27 |pages= 4317-22 |year= 2002 |pmid= 12082619 |doi= 10.1038/sj.onc.1205556 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Ramírez de Molina A, Rodríguez-González A, Gutiérrez R, ''et al.'' |title=Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 3 |pages= 580-3 |year= 2002 |pmid= 12176020 |doi=  }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Gallego-Ortega D, Ramirez De Molina A, Gutierrez R |title=Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer |journal=Int. J. Oncol. |volume=29 |issue= 2 |pages= 335–40 |year= 2006 |pmid= 16820874 |doi=  10.3892/ijo.29.2.335|display-authors=etal|url=https://digital.csic.es/bitstream/10261/24773/1/ijo_29_2_335_PDF.pdf }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Enaw JO, Zhu H, Yang W |title=CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population |journal=BMC Medicine |volume=4|pages= 36 |year= 2007 |pmid= 17184542 |doi= 10.1186/1741-7015-4-36 | pmc=1770928 |display-authors=etal}}
*{{cite journal  | author=Gallego-Ortega D, Ramirez De Molina A, Gutierrez R, ''et al.'' |title=Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer. |journal=Int. J. Oncol. |volume=29 |issue= 2 |pages= 335-40 |year= 2006 |pmid= 16820874 |doi=  }}
*{{cite journal  | author=Enaw JO, Zhu H, Yang W, ''et al.'' |title=CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population. |journal=BMC medicine |volume=4 |issue=  |pages= 36 |year= 2007 |pmid= 17184542 |doi= 10.1186/1741-7015-4-36 }}
}}
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{{refend}}
{{refend}}
{{PDB Gallery|geneid=1119}}
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Latest revision as of 20:01, 31 October 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Choline kinase alpha is an enzyme that in humans is encoded by the CHKA gene.[1][2][3]

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene.[3]

In melanocytic cells CHKA gene expression may be regulated by MITF.[4]

References

  1. ↑ Hosaka K, Tanaka S, Nikawa J, Yamashita S (Aug 1992). "Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation". FEBS Lett. 304 (2–3): 229–32. doi:10.1016/0014-5793(92)80625-Q. PMID 1618328.
  2. ↑ Aoyama C, Liao H, Ishidate K (Mar 2004). "Structure and function of choline kinase isoforms in mammalian cells". Prog Lipid Res. 43 (3): 266–81. doi:10.1016/j.plipres.2003.12.001. PMID 15003397.
  3. ↑ 3.0 3.1 "Entrez Gene: CHKA choline kinase alpha".
  4. ↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

External links

Further reading



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