CABLES1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''CDK5 and ABL1 enzyme substrate 1''' is a [[protein]] that in humans is encoded by the ''CABLES1'' [[gene]].<ref name="pmid12477932">{{cite journal | vauthors = Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | journal = Proc Natl Acad Sci U S A | volume = 99 | issue = 26 | pages = 16899–903 |date=Dec 2002 | pmid = 12477932 | pmc = 139241 | doi = 10.1073/pnas.242603899 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CABLES1 Cdk5 and Abl enzyme substrate 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91768| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Cdk5 and Abl enzyme substrate 1
| HGNCid = 25097
| Symbol = CABLES1
| AltSymbols =; FLJ35924; HsT2563
| OMIM = 609194
| ECnumber = 
| Homologene = 11097
| MGIid = 1927065
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016538 |text = cyclin-dependent protein kinase regulator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0051302 |text = regulation of cell division}} {{GNF_GO|id=GO:0051726 |text = regulation of cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 91768
    | Hs_Ensembl = ENSG00000134508
    | Hs_RefseqProtein = NP_612384
    | Hs_RefseqmRNA = NM_138375
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 18969725
    | Hs_GenLoc_end = 19091329
    | Hs_Uniprot = Q8TDN4
    | Mm_EntrezGene = 63955
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_022021
    | Mm_RefseqProtein = NP_071304
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Cdk5 and Abl enzyme substrate 1''', also known as '''CABLES1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CABLES1 Cdk5 and Abl enzyme substrate 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91768| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = CABLES1 is a cyclin-dependent kinase (CDK)-binding protein that plays a role in proliferation and/or differentiation (Zukerberg et al., 2004).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: CABLES1 Cdk5 and Abl enzyme substrate 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91768| accessdate = }}</ref>
| summary_text = CABLES1 is a [[cyclin-dependent kinase]] (CDK)-binding protein that plays a role in proliferation and/or [[cell differentiation]] (Zukerberg et al., 2004).[supplied by OMIM].<ref name="entrez"/> It is a [[tumor suppressor gene]] which losing it (by mutations, knockout, knockdown or inactivation)  may lead to [[colorectal cancer]] CRC.
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CABLES1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Matsuoka M, Matsuura Y, Semba K, Nishimoto I |title=Molecular cloning of a cyclin-like protein associated with cyclin-dependent kinase 3 (cdk 3) in vivo. |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 2 |pages= 442-7 |year= 2000 |pmid= 10873625 |doi= 10.1006/bbrc.2000.2965 }}
*{{cite journal  | vauthors=Matsuoka M, Matsuura Y, Semba K, Nishimoto I |title=Molecular cloning of a cyclin-like protein associated with cyclin-dependent kinase 3 (cdk 3) in vivo. |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 2 |pages= 442–7 |year= 2000 |pmid= 10873625 |doi= 10.1006/bbrc.2000.2965 }}
*{{cite journal  | author=Zukerberg LR, Patrick GN, Nikolic M, ''et al.'' |title=Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. |journal=Neuron |volume=26 |issue= 3 |pages= 633-46 |year= 2000 |pmid= 10896159 |doi=  }}
*{{cite journal  | vauthors=Zukerberg LR, Patrick GN, Nikolic M |title=Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. |journal=Neuron |volume=26 |issue= 3 |pages= 633–46 |year= 2000 |pmid= 10896159 |doi=10.1016/S0896-6273(00)81200-3 |display-authors=etal}}
*{{cite journal  | author=Yamochi T, Nishimoto I, Okuda T, Matsuoka M |title=ik3-1/Cables is associated with Trap and Pctaire2. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 5 |pages= 1045-50 |year= 2001 |pmid= 11527406 |doi= 10.1006/bbrc.2001.5493 }}
*{{cite journal  | vauthors=Yamochi T, Nishimoto I, Okuda T, Matsuoka M |title=ik3-1/Cables is associated with Trap and Pctaire2. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 5 |pages= 1045–50 |year= 2001 |pmid= 11527406 |doi= 10.1006/bbrc.2001.5493 }}
*{{cite journal  | author=Wu CL, Kirley SD, Xiao H, ''et al.'' |title=Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers. |journal=Cancer Res. |volume=61 |issue= 19 |pages= 7325-32 |year= 2001 |pmid= 11585773 |doi=  }}
*{{cite journal  | vauthors=Wu CL, Kirley SD, Xiao H |title=Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers. |journal=Cancer Res. |volume=61 |issue= 19 |pages= 7325–32 |year= 2001 |pmid= 11585773 |doi=  |display-authors=etal}}
*{{cite journal  | author=Tsuji K, Mizumoto K, Yamochi T, ''et al.'' |title=Differential effect of ik3-1/cables on p53- and p73-induced cell death. |journal=J. Biol. Chem. |volume=277 |issue= 4 |pages= 2951-7 |year= 2002 |pmid= 11706030 |doi= 10.1074/jbc.M108535200 }}
*{{cite journal  | vauthors=Tsuji K, Mizumoto K, Yamochi T |title=Differential effect of ik3-1/cables on p53- and p73-induced cell death. |journal=J. Biol. Chem. |volume=277 |issue= 4 |pages= 2951–7 |year= 2002 |pmid= 11706030 |doi= 10.1074/jbc.M108535200 |display-authors=etal}}
*{{cite journal  | author=Yamochi T, Semba K, Tsuji K, ''et al.'' |title=ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). |journal=Eur. J. Biochem. |volume=268 |issue= 23 |pages= 6076-82 |year= 2002 |pmid= 11733001 |doi=  }}
*{{cite journal  | vauthors=Yamochi T, Semba K, Tsuji K |title=ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). |journal=Eur. J. Biochem. |volume=268 |issue= 23 |pages= 6076–82 |year= 2002 |pmid= 11733001 |doi=10.1046/j.0014-2956.2001.02555.x |display-authors=etal}}
*{{cite journal  | author=Sato H, Nishimoto I, Matsuoka M |title=ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl. |journal=Biochim. Biophys. Acta |volume=1574 |issue= 2 |pages= 157-63 |year= 2002 |pmid= 11955625 |doi=  }}
*{{cite journal  | vauthors=Sato H, Nishimoto I, Matsuoka M |title=ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl. |journal=Biochim. Biophys. Acta |volume=1574 |issue= 2 |pages= 157–63 |year= 2002 |pmid= 11955625 |doi=  10.1016/S0167-4781(01)00367-0}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Tan D, Kirley S, Li Q |title=Loss of cables protein expression in human non-small cell lung cancer: a tissue microarray study. |journal=Hum. Pathol. |volume=34 |issue= 2 |pages= 143–9 |year= 2003 |pmid= 12612882 |doi= 10.1053/hupa.2003.26 |display-authors=etal}}
*{{cite journal  | author=Tan D, Kirley S, Li Q, ''et al.'' |title=Loss of cables protein expression in human non-small cell lung cancer: a tissue microarray study. |journal=Hum. Pathol. |volume=34 |issue= 2 |pages= 143-9 |year= 2003 |pmid= 12612882 |doi= 10.1053/hupa.2003.26 }}
*{{cite journal  | vauthors=Dong Q, Kirley S, Rueda B |title=Loss of cables, a novel gene on chromosome 18q, in ovarian cancer. |journal=Mod. Pathol. |volume=16 |issue= 9 |pages= 863–8 |year= 2004 |pmid= 13679449 |doi= 10.1097/01.MP.0000084434.88269.0A |display-authors=etal}}
*{{cite journal  | author=Dong Q, Kirley S, Rueda B, ''et al.'' |title=Loss of cables, a novel gene on chromosome 18q, in ovarian cancer. |journal=Mod. Pathol. |volume=16 |issue= 9 |pages= 863-8 |year= 2004 |pmid= 13679449 |doi= 10.1097/01.MP.0000084434.88269.0A }}
*{{cite journal  | vauthors=Matsuoka M, Sudo H, Tsuji K |title=ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways. |journal=Biochem. Biophys. Res. Commun. |volume=312 |issue= 2 |pages= 520–9 |year= 2004 |pmid= 14637168 |doi=10.1016/j.bbrc.2003.10.142 |display-authors=etal}}
*{{cite journal  | author=Matsuoka M, Sudo H, Tsuji K, ''et al.'' |title=ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways. |journal=Biochem. Biophys. Res. Commun. |volume=312 |issue= 2 |pages= 520-9 |year= 2004 |pmid= 14637168 |doi=  }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Zukerberg LR, DeBernardo RL, Kirley SD |title=Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer. |journal=Cancer Res. |volume=64 |issue= 1 |pages= 202–8 |year= 2004 |pmid= 14729625 |doi=10.1158/0008-5472.CAN-03-2833 |display-authors=etal}}
*{{cite journal  | author=Zukerberg LR, DeBernardo RL, Kirley SD, ''et al.'' |title=Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer. |journal=Cancer Res. |volume=64 |issue= 1 |pages= 202-8 |year= 2004 |pmid= 14729625 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Zhang H, Duan HO, Kirley SD |title=Aberrant splicing of cables gene, a CDK regulator, in human cancers. |journal=Cancer Biol. Ther. |volume=4 |issue= 11 |pages= 1211–5 |year= 2006 |pmid= 16177568 |doi=  10.4161/cbt.4.11.2085|display-authors=etal}}
*{{cite journal  | author=Zhang H, Duan HO, Kirley SD, ''et al.'' |title=Aberrant splicing of cables gene, a CDK regulator, in human cancers. |journal=Cancer Biol. Ther. |volume=4 |issue= 11 |pages= 1211-5 |year= 2006 |pmid= 16177568 |doi=  }}
*{{cite journal  | vauthors=Nusbaum C, Zody MC, Borowsky ML |title=DNA sequence and analysis of human chromosome 18. |journal=Nature |volume=437 |issue= 7058 |pages= 551–5 |year= 2005 |pmid= 16177791 |doi= 10.1038/nature03983 |display-authors=etal}}
*{{cite journal  | author=Nusbaum C, Zody MC, Borowsky ML, ''et al.'' |title=DNA sequence and analysis of human chromosome 18. |journal=Nature |volume=437 |issue= 7058 |pages= 551-5 |year= 2005 |pmid= 16177791 |doi= 10.1038/nature03983 }}
*{{cite journal  | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |display-authors=etal}}
*{{cite journal  | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal  | vauthors=Hirao N, Sato S, Gotoh T |title=NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation. |journal=FEBS Lett. |volume=580 |issue= 27 |pages= 6464–70 |year= 2007 |pmid= 17101133 |doi= 10.1016/j.febslet.2006.10.065 |display-authors=etal}}
*{{cite journal  | author=Hirao N, Sato S, Gotoh T, ''et al.'' |title=NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation. |journal=FEBS Lett. |volume=580 |issue= 27 |pages= 6464-70 |year= 2007 |pmid= 17101133 |doi= 10.1016/j.febslet.2006.10.065 }}
}}
}}
{{refend}}
{{refend}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


{{gene-18-stub}}
{{gene-18-stub}}
{{WikiDoc Sources}}

Latest revision as of 09:07, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CDK5 and ABL1 enzyme substrate 1 is a protein that in humans is encoded by the CABLES1 gene.[1][2]

CABLES1 is a cyclin-dependent kinase (CDK)-binding protein that plays a role in proliferation and/or cell differentiation (Zukerberg et al., 2004).[supplied by OMIM].[2] It is a tumor suppressor gene which losing it (by mutations, knockout, knockdown or inactivation) may lead to colorectal cancer CRC.

References

  1. ↑ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  2. ↑ 2.0 2.1 "Entrez Gene: CABLES1 Cdk5 and Abl enzyme substrate 1".

External links

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=CABLES1&oldid=1418497"